10/12/2008 05:12 am ET Updated May 25, 2011

Julia Roberts And Dave Matthews Team For Cancer Concert

Longtime friends Julia Roberts and Dave Matthews joined forces Wednesday night at the sold-out Stand Up For a Cure concert at Madison Square Garden to benefit lung cancer research.

The singer - who said he was just 10 years old when his father died of lung cancer - movingly told the audience, "One day, we hopefully won't need to have events like this."

Roberts started the night off by introducing her good pal and his band to the raucous New York fans: "I cannot tell you how excited I am to be in the greatest city in the world to introduce one of the greatest bands of the world!"

As the crowd roared, she thanked everyone who came to the concert. "We should all feel good about participating," she said. "I'm thrilled to be able to say that on September 10 that we are welcoming some of the heroes and first responders from September 11. As New Yorkers, we are beholden to all of them."

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