03/23/2010 05:12 am ET Updated May 25, 2011

Nancy Pelosi Under Pressure To Salvage Health Care Agenda

Scott Brown's stunning upset victory in Massachusetts has reshuffled the Senate, but its immediate consequences have fallen hardest on House Speaker Nancy Pelosi, who now faces perhaps the defining moment of her career.

Tuesday's loss of the 60-vote Democratic Senate majority means Pelosi must shoulder the main burden of salvaging President Barack Obama's health care reform deal, even as she copes with an uprising among Democratic incumbents terrified by the far-reaching implications of the party's Massachusetts meltdown.

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