06/14/2011 02:15 pm ET Updated Dec 06, 2017

Kelsey Grammer In 'Boss': New Show Heads For Starz (VIDEO)

And you thought Kelsey Grammer's personal life was a bit dramatic.

After weathering a winter that involved the low of divorce and the immediately following high of marriage, Grammer is back to what he does best: acting.

The Emmy-winning "Frasier" star returns to television in the new Starz original series, "Boss." Part political and part personal drama, Grammer stars as the mayor of Chicago -- an historically dramatic position, to say the least -- who balances his political (and dirty) empire with a secret, crippling illness.

The show debuts in October. The synopsis follows:

Mayor Tom Kane (Kelsey Grammer) sits like a spider at the center of Chicago's web of power; a web built on a covenant with the people. They want to be led; they want disputes settled, jobs dispensed, and loyalties rewarded. If he achieves through deception and troubling morality, so be it. As long as he gets the job done, they look the other way.

Yet despite being the most effective mayor in recent history, a degenerative brain disorder is ripping everything away from him. He can't trust his memory, his closest allies, or even himself.

Kane's wife Meredith (Connie Nielsen) knows nothing. Theirs is a marriage of convenience. Kitty O'Neil (Kathleen Robertson), Kane's advisor, has her suspicions but stays silent. And Kane's political advisor Ira Stone (actor), a Yale graduate with a rough edge, remains question-less. Only Alice (Hannah Ware), Kane's estranged daughter, has a chance of learning his secret. This is going to be the toughest term yet for the Boss.