01/26/2012 01:41 am ET Updated Mar 26, 2012

'The Rosie Show': Kathy Griffin On Cracking Jokes About Oprah Winfrey (VIDEO)

Kathy Griffin has made quite a name for herself by poking fun at the current celebrity-obsessed culture. She's taken plenty of cheap shots at the Kardashians and other people who've become famous for being famous.

But that doesn't mean she's let other larger than life personalities off of her radar. On "The Rosie Show" (Weeknights 7 p.m. EST on OWN), Rosie O'Donnell talked about Griffin's jokes about Oprah Winfrey.

"I think that she is such a big target that you don't think of her in a humanized way," O'Donnell suggested. "That you think of her more like people think of Madonna. As an entity."

But Griffin sees it in much simpler terms. "I make fun of Oprah because of her behavior," she said. "Of course I see her as a human being, and sometimes she will say something that is so over the top to me that I find it amusing."

She went on to explain that even hanging out with a particular celebrity won't change her act. She said to Ryan Seacrest when the two were out to lunch, "If you say something like super crazy, there's no gag orders."

Catch "The Rosie Show" every weeknight at 7 p.m. EST on OWN.

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