According to the celebrity news site, officials from the L.A. County Department of Children and Family Services took the boys from Mueller's home on Thursday night out of concern for their safety, given allegations of her ongoing drug use.
The boys are now in the care of Denise Richards, another of Sheen's ex-wives.
This is not the first time Richards has stepped in to help her ex-husband and his ex-wife. She previously looked after the twins while Mueller was reportedly doing a stint in rehab to treat an Adderall addiction. Richards has two young daughters from her marriage to Sheen and one adopted daughter.
In December, Richards told "Access Hollywood" that she is always more than willing to pitch in when needed.
“They’re our family and they’re Sam and Lola’s brothers and I can’t imagine growing up without my sister, so anytime she needs help, I’m there for the boys,” she said. “[Sam and Lola] are the best big sisters to [the boys] and they love them.”
Click through the slideshow below to see nine women Sheen has romanced throughout the years.