Hillary Clinton's potential run in the 2016 presidential election has raised questions about her ability to lead. Fox News' Bill O'Reilly said in an interview that "there's got to be a downside" to having a female president because they have to deal with aggressive powers like Russia and Iran.
Colbert mocked O'Reilly's claim Wednesday night and wondered how a woman could ever do the job of president of the United States.
"There's gotta be a downside to a woman president. I mean, how is she going to press the nuclear launch button?" Colbert asked. "Everything in the Oval Office is penis-activated!"
Colbert said that there are just too many reasons why having a female president would be too complicated, and possibly jeopardize the safety of the country.
"Plus -- I don't want to get too technical or scientific -- but women sit down to pee," he pointed out. "If there's a terror attack, a man could just zip and go!"
Watch the video for the full clip.