04/18/2014 02:26 pm ET Updated Feb 02, 2016

'The Normal Heart' Trailer: Mark Ruffalo, Matt Bomer And Julia Roberts Star In HBO's Adaptation (VIDEO)

If HBO's adaptation of Larry Kramer's masterpiece "The Normal Heart" is as chilling as this new trailer, prepare to stock up on some tissues before May 25.

Directed by Ryan Murphy, "Heart" features an all-star cast, including Julia Roberts, Mark Ruffalo, Matt Bomer and Jim Parsons, and is based on Kramer's acclaimed 1985 play about the rise of the HIV/AIDS crisis in New York.

Fans of HBO's "Looking" will be sure to spot hunky star Jonathan Groff in the early moments of this new clip, but from the looks of it, things don't end on a happy note for his character.

"The Normal Heart" airs May 25 at 9 p.m. EST on HBO.