SCIENCE
10/03/2018 05:51 am ET Updated Oct 03, 2018

Frances H. Arnold, George P. Smith and Sir Gregory P. Winter Win 2018 Nobel Prize In Chemistry

This year's chemistry prize was all about "harnessing the power of evolution."
The 2018 Nobel Prize laureates for chemistry are shown on the screen from left, Frances H. Arnold of the U.S., George P. Smit
AP
The 2018 Nobel Prize laureates for chemistry are shown on the screen from left, Frances H. Arnold of the U.S., George P. Smith of the U.S., and Gregory P. Winter of Britain, during the announcement at the Royal Swedish Academy of Sciences in Stockholm, on Oct. 3.

STOCKHOLM (AP) — Three researchers who “harnessed the power of evolution” to produce enzymes and antibodies that have led to new drugs and biofuels have been named winners of the Nobel Prize in chemistry.

Half of the 9-million-kronor ($1.01 million) prize goes to Frances Arnold of the California Institute of Technology. The other half is shared by George Smith of the University of Missouri and Gregory Winter of the MRC molecular biology lab in Cambridge, England.

The Royal Swedish Academy of Sciences, which chose the winners on Wednesday, said Arnold conducted the first directed evolution of enzymes, whose uses include “more environmentally friendly manufacturing of chemical substances such as pharmaceuticals and the production of renewable fuels.”

Smith developed a method to evolve new proteins and Winter used the method to evolve antibodies, which are disease-fighting proteins in the blood.

The first pharmaceutical based on Winter’s work was approved for use in 2002 and is employed to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases, the academy said.

Reached by The Associated Press Wednesday, Smith credited others for the work that led to his breakthrough.

“Very few research breakthroughs are novel. Virtually all of them build on what went on before. It’s happenstance. That was certainly the case with my work,” he said. “Mine was an idea in a line of research that built very naturally on the lines of research that went before.”

Smith said he learned of the prize in a pre-dawn phone call from Stockholm. “It’s a standard joke that someone with a Swedish accent calls and says you won! But there was so much static on the line, I knew it wasn’t any of my friends,” he said.

The medicine prize was awarded Monday to American and Japanese researchers. Scientists from the United States, Canada and France shared the physics prize Tuesday.

On Tuesday, researchers from the United States, Canada and France were awarded the physics prize for advances in laser technologies.

The winner of the Nobel Peace Prize is to be announced Friday. No literature prize will be awarded this year. The Nobel Memorial Prize in Economic Sciences, honoring the man who endowed the five Nobel Prizes, will be revealed on Oct. 8.

2018 Nobel Prizes

Monday: Nobel Prize in physiology or medicine was awarded to James P. Allison and Tasuku Honjo for advances in discovering how the immune system can fight off cancer.

Tuesday: Nobel Prize in physics was awarded to Arthur Ashkin, Gérard Mourou and Donna Strickland for groundbreaking inventions in the field of laser physics.

Wednesday: Nobel Prize in chemistry was awarded to Frances Arnold, George Smith, and Gregory Winter for using evolutionary methods to solve modern problems.

Friday: Nobel Peace Prize will be awarded.

Monday, Oct. 8: Nobel Memorial Prize in Economic Sciences will be awarded.

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