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Many consider randomized control trials, or RCTs, to be the "gold standard" for evidence. Randomization provides a high degree of proof for a very narrow set of facts: a particular program, under a particular set of conditions, for a particular population of people, at a particular time, made a difference.
My mother, who was once the primary caretaker of her husband and three kids, who worked as a substitute teacher and part time editor of the Harvard Business Review, who threw amazing parties and volunteered at the temple and ran a gourmet catering business in her spare time, has Alzheimer's Disease, just as her mother and brother had it before her.