ong-term heavy use of marijuana may cause two important brain structures to shrink, Australian researchers said on Monday.
Brain scans showed the hippocampus and amygdala were smaller in men who were heavy marijuana users compared to nonusers, the researchers said. The men had smoked at least five marijuana cigarettes daily for on average 20 years.
The hippocampus regulates memory and emotion, while the amygdala plays a critical role in fear and aggression.
The study, published in the American Medical Association's journal Archives of General Psychiatry, also found the heavy cannabis users earned lower scores than the nonusers in a verbal learning task -- trying to recall a list of 15 words.
The marijuana users were more likely to exhibit mild signs of psychotic disorders, but not enough to be formally diagnosed with any such disorder, the researchers said.