MIT Student Discovers How To Fold Human Genome

MIT Student Discovers How To Fold Human Genome

Until recently, the process of how genomic DNA neatly folds itself into the nucleus of a cell -- twisting and contorting into a work of astonishingly compact molecular origami -- had perplexed biologists.

When unstretched onto its two-dimensional, double-helix form, the human genome spans nearly two meters in length, yet it must fit inside the cell nucleus, which is only a hundredth of a millimeter in diameter. How exactly the genome can compress into an unknown three-dimensional structure and retain some sort of underlying order, all while persisting tangle-free, remained a fundamental mystery in structural biology.

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