In the new film "Due Date" (which opens nation-wide today), Robert Downey Jr and Zach Galifianakis, as an expectant father and aspiring actor, race west from Atlanta across the south to LA.
It's a great route, and even better if you take it slow.
Here are Lonely Planet's list of things to do at main stops along the way.
Text and captions courtesy of Lonely Planet. Copyright Lonely Planet 2010.