If you want record-setting sunshine, St. Petersburg is your city—it once soaked up a Guinness-certified 768 straight days of rays. But there's an asterisk: The people of St. Pete also have the darkest clouds hanging over their heads. We put America on the therapist's couch and discovered that not only is St. Petersburg our Saddest City, but Florida in general seems to be a depressing place to live.
Of course, we aren't shrinks, so our diagnosis is more statistical than psychological. We calculated suicide rates (CDC) and unemployment rates (Bureau of Labor Statistics, as of June 2011). Then we tapped SimplyMap for the percentage of households that use antidepressants as well as the number of people who report feeling the blues all or most of the time.