When asked about the break-up rumor by French TV show "Grand Journal" Tuesday, the 39-year-old actress said: "Yes, they [the rumors] are false."
The couple, who have spent the majority of their life together in the southern French town of Plan-de-la-Tour, have two children together, 12-year-old Lily-Rose, and 9-year-old Jack.
In December 2010, Depp told "Extra" that he didn't need a "piece of paper" to prove his commitment to Paradis, musing that "marriage is really from soul to soul, heart to heart."
Their rumored split brought to mind other never-married celebrity couples who stayed together for years, only to call it quits in the end. Below, some of those couples' stories.