When asked about the break-up rumor by French TV show "Grand Journal" Tuesday, the 39-year-old actress said: "Yes, they [the rumors] are false."
The couple, who have spent the majority of their life together in the southern French town of Plan-de-la-Tour, have two children together, 12-year-old Lily-Rose, and 9-year-old Jack.
In December 2010, Depp told "Extra" that he didn't need a "piece of paper" to prove his commitment to Paradis, musing that "marriage is really from soul to soul, heart to heart."
Their rumored split brought to mind other never-married celebrity couples who stayed together for years, only to call it quits in the end. Below, some of those couples' stories.
Jessica Lange and actor-writer Sam Shepard met on the set of 1982's "Frances." The couple went on to spend nearly three decades together, raising two children, Hannah, 26, and Samuel, 24, all without ever saying "I do." The two remained similarly low-key with their breakup; reports of their split in December 2011 came two years after the couple had really called it quits in 2009, after 27 years together.
Zoe Saldana and entrepreneur Keith Britton announced their engagement after ten years together in June 2010. At the time, the actress told "Access Hollywood" that Britton was the only person who knew "the real Zoe." In November 2011, the actress' rep announced that the two had amicably separated. Despite their split, the pair remain business partners in the website My Fashion Data Base, a fashion industry credit site likened to IMDB.
Charlize Theron and Irish actor Stewart Townsend split in 2010 after nine years together. In 2007, Townsend told People magazine that the pair were "married," despite never officially tying the knot. "We love each other and we want to spend our lives together," he said in 2007. "I don't need a certificate or the state or the church to say otherwise. So no there's no big official story on a wedding, but we are married ... I consider her my wife and she considers me her husband." Theron recently compared their relationship to a marriage as well, telling Entertainment Weekly in November 2011 that "I was basically married for almost 10 years and it didn't work out."
Elizabeth Hurley famously stuck by longtime beau Hugh Grant in 1995, after the star was arrested and charged for indecent conduct with a prostitute. The couple eventually split in 2000 after 13 years together. Hurley, who's since married and divorced businessman Arun Nayar , now calls Hugh her "best friend" and asked him to be godfather to Damian, her 9-year-old son with ex Stephen Bing.