Rachel Maddow is known for her perennially sunny attitude on-air, but in the latest issue of Rolling Stone, the MSNBC host talked about her darker moods, which she said can sometimes sink into depression.

The profile by Ben Wallace-Wells is partially built around Maddow's infamous "Meet the Press" argument with GOP strategist Alex Castellanos about gender pay equity. That was about as angry as viewers have ever seen her get, and it was hardly off-the-charts anger.

However, Maddow told Wells that just because viewers might not see it doesn't mean it doesn't exist.

"I am as rage-filled as the next guy," she said. Talking about a show she didn't like, she added, "Why do I still have one-star shows? It's me - failure."

She then said she suffers from "cyclical depression." It's something she's talked about before, but that has not received much public attention.

"One of the manifestations of depression for me is that I lose my will," she told Wells. And I thereby lose my ability to focus ... if I'm not depressed and I'm on and I can focus and I can think through something hard and without interruption and without existential emptiness that comes from depression, that gives me - not mania. But I exalt. I exalt in not being depressed."

Maddow elaborated on the subject in an April interview with Terry Gross. She said that she has wrestled with bouts of depression since she was 11 or 12, and that she can sometimes lose her sense of smell when they take over.

"Coping with depression is something that is part of the everyday way that I live and have lived for as long as I can remember," she said. "When you are depressed, it's like the rest of the world is the mother ship, and you're out there on a little pod and your line gets cut and you don't connect with anything. You sort of disappear."

Read the full Rolling Stone profile here.

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  • Iowa Caucus Coverage

    Rachel Maddow, host of MSNBC's "Rachel Maddow Show" (center), moderated coverage of the 2012 Iowa caucus with her fellow network hosts.

  • Comparing GOP Candidates From 2008 And 2012

  • Mocking Herman Cain

  • On Cover Of The Hollywood Reporter

  • Interviewing Joe Miller Supporter

  • At New Yorker Festival

  • On 'Meet The Press'

  • On 'Meet The Press'

  • At The State Department

    Rachel Maddow attends a luncheon hosted by U.S. Secretary of State Hillary Clinton in honor of British Prime Minister David Cameron on March 14, 2012, at the State Department in Washington, D.C. (Photo by Karen Bleier/AFP/Getty Images)

  • At The State Department

    Rachel Maddow arrives for a lunch in honor of Prime Minister David Cameron at the State Department on March 14, 2012, in Washington, D.C. (Photo by Brendan Hoffman/Getty Images)

  • In Conversation With David Letterman

    Rachel Maddow and David Letterman discuss the headlines of the day in Emens Auditorium at Ball State University, Letterman's alma mater, on Dec. 2, 2011, in Muncie, Ind. (Photo by Ron Hoskins/Getty Images)

  • In Conversation With David Letterman

    Rachel Maddow discusses the headlines of the day in Emens Auditorium at Ball State University, David Letterman's alma mater, on Dec. 2, 2011, in Muncie, Ind. (Photo by Ron Hoskins/Getty Images)

  • In Conversation With David Letterman

    Rachel Maddow and David Letterman discuss the headlines of the day in Emens Auditorium at Ball State University, Letterman's alma mater, on Dec. 2, 2011, in Muncie, Ind. (Photo by Ron Hoskins/Getty Images)

  • 2011 Summer TCA Tour

    MSNBC President Phil Griffin and MSNBC hosts Rachel Maddow and Lawrence O'Donnell (left to right) speak during the NBC Universal portion of the Television Critics Association's 2011 summer tour, held at the Beverly Hilton Hotel on Aug. 2, 2011, in Beverly Hills, Calif. (Photo by Frederick M. Brown/Getty Images)

  • 2011 Summer TCA Press Tour

  • At The White House

    MSNBC hosts Rachel Maddow (left) and Keith Olbermann (second from left) talk with White House Communications Director Anita Dunn (second from right) and Deputy Press Secretary Bill Burton (right) outside the White House on Oct. 19, 2009, in Washington, D.C. (Photo by Chip Somodevilla/Getty Images)

  • At The White House

    MSNBC hosts Rachel Maddow (left) and Keith Olbermann (second from left) talk with White House Communications Director Anita Dunn (second from right) and Deputy Press Secretary Bill Burton (right) outside the White House on Oct. 19, 2009, in Washington, D.C. (Photo by Chip Somodevilla/Getty Images)

  • Nancy Pelosi, Rachel Maddow

    House Minority Leader Leader Nancy Pelosi of Calif. accompanied by MSNBC's Rachel Maddow, participates in a conversation moderated by Maddow, in Washington, Wednesday, June 6, 2012, to talk about her experiences and achievements over 25 years in Congress. (AP Photo/Haraz N. Ghanbari)

  • NAACP-Holder

    Jo Ann Wright, of Southfield, left, gets her photo taken with political commentator Rachel Maddow who was the recipient of the Ida B. Wells Freedom and Justice Award at the 57th annual NAACP Fight For Freedom Fund Dinner at Cobo Hall in Detroit Sunday May 6, 2012. U.S. Attorney General Eric Holder was the keynote speaker. (AP Photos/David Guralnick / The Detroit News)

  • David Brooks, George Stephanopoulos, Rahm Emanuel, Rachel Maddow, Alex Castellanos

    Mayor Rahm Emanuel, second from left, shares a stage with George Stephanopoulos, left, David Brooks, center, Rachel Maddow and Alex Castellanos, right, during a panel discussion, "2012: The Path to the Presidency", at the University of Chicago in Chicago on Thursday, Jan. 19, 2012. (AP Photo/Nam Y. Huh)

  • Rachel Maddow

    Rachel Maddow, host of "The Rachel Maddow Show" on MSNBC, shares a stage with pundits during a panel discussion, "2012: The Path to the Presidency", at the University of Chicago in Chicago on Thursday, Jan. 19, 2012. (AP Photo/Nam Y. Huh)

  • Rachel Maddow, Lawrence O'Donnell, Chris Matthews

    MSNBC hosts Rachel Maddow, left, Lawrence O'Donnell, center, and Chris Matthews take part in a panel discussion at the NBC Universal summer press tour, Tuesday, Aug. 2, 2011, in Beverly Hills, Calif. (AP Photo/Chris Pizzello)

  • Lawrence O'Donnell, Rachel Maddow

    Lawrence O'Donnell, right, host of the MSNBC show "The Last Word," answers a question as Rachel Maddow, host of "The Rachel Maddow Show," look on at the NBC Universal summer press tour, Tuesday, Aug. 2, 2011, in Beverly Hills, Calif. (AP Photo/Chris Pizzello)

  • David Letterman In Conversation With Rachel Maddow

    MUNCIE, IN - DECEMBER 02: Rachel Maddow and David Letterman (R) discuss the headlines of the day in Emens Auditorium at Ball State University, Letterman's alma mater, on December 2, 2011 in Muncie, Indiana. (Photo by Ron Hoskins/Getty Images)

  • David Letterman In Conversation With Rachel Maddow

    MUNCIE, IN - DECEMBER 02: Rachel Maddow and David Letterman (R) discuss the headlines of the day in Emens Auditorium at Ball State University, Letterman's alma mater, on December 2, 2011 in Muncie, Indiana. (Photo by Ron Hoskins/Getty Images)

  • Alaska's Three Senate Candidates Debate In Anchorage

    ANCHORAGE - OCTOBER 26: Television and radio personality Rachel Maddow (R) speaks with supporters of Republican candidate Joe Miller prior to his debate with write-in candidate Sen. Lisa Murkowski (R-AK), and Democratic candidate Scott McAdams hosted by The Alaska World Affairs Council and Rotary Clubs of Anchorage at the Dena'ina Convention Center October 26, 2010 in Anchorage, Alaska. Voters will go to the polls on November 2, 2010. (Photo by Clark James Mishler/Getty Images)