NEW YORK — Maybe Roger Federer had too much time off between U.S. Open matches. This much is certain: He won't be playing again at this year's tournament after losing to Tomas Berdych in the quarterfinals.

Five-time champion Federer departed Flushing Meadows before the semifinals for the first time since 2003, stunned by the sixth-seeded Berdych 7-6 (1), 6-4, 3-6, 6-3 on Wednesday night.

"I just didn't come up with the goods tonight," Federer said. "It was unfortunate."

His famous forehand was way off for much of the evening: 24 of his 40 unforced errors came off that wing. The 6-foot-5 Berdych, meanwhile, kept pounding serves and groundstrokes right where he wanted them, finishing with a total of 14 aces, 30 winners and only 21 unforced errors.

"There is no better moment than this one so far," said Berdych, who will face Olympic champion Andy Murray in the semifinals Saturday.

It was Berdych's fourth victory in his last seven meetings against 17-time Grand Slam trophy winner Federer, including in the 2010 Wimbledon quarterfinals en route to a runner-up finish to Rafael Nadal at the All England Club.

Federer hadn't competed since Saturday, and he looked rather rusty, particularly for the first two sets Wednesday. The man he was supposed to play in the fourth round Monday, Mardy Fish, withdrew because of a health scare.

In dark sneakers bearing a tiny gold trophy with a black "5" etched on it – representing his title count at the U.S. Open – the top-seeded Federer failed in his bid to reach the semifinals in New York for the ninth consecutive year.

He won the championship every year from 2004 through 2008, but his 40-match winning streak at the hard-court major tournament ended with a loss to Juan Martin del Potro in the 2009 final. Federer then was beaten by Novak Djokovic in the semifinals in 2010 and 2011.

This year, Federer took another step backward, bothered by another big hitter.

Berdych absolutely controlled the opening-set tiebreaker, capping it with a 128 mph ace.

And then, quick as can be, he broke to begin the second set, first smacking a superb forehand winner down the line on a full sprint, then watching Federer miss two wild forehands on consecutive points.

Berdych broke again in the third and led 3-1 there before Federer began to find his form, briefly making this interesting. Berdych also hurt himself, showing signs of nerves by double-faulting twice while getting broken to 3-all.

That was part of a stretch in which Federer looked a lot more like, well, Roger Federer, taking four games in a row and 19 of 24 points to take the third set. He ended it with a perfect drop shot, and all of a sudden, the possibility of a ninth career comeback from a two-set deficit seemed possible.

Berdych, after all, had blown such a lead to Federer before, in the fourth round of the 2009 Australian Open.

Not this time, though.

At 2-2 in the fourth, Federer conjured up a terrific cross-court backhand passing winner that left Berdych skidding and stumbling as he tried to change directions while moving toward the net. Berdych dropped his racket as he fell, scraping his fingers along the blue court.

After taking several seconds to compose himself – and to press a cold water bottle against his hand – Berdych lost the next point, too, to fall behind love-30, then took the next four points to hold for a 3-2 lead.

And three games later, Berdych smacked a cross-court forehand winner to break Federer and make it 5-3. All Berdych had left to do was hold serve once, and he did it, delivering a 124 mph ace to get to match point, and a 124 mph service winner to convert it.

"When you leave it a little bit on Roger's game, and he starts to go for it, it could be a really big problem," Berdych said. "So I was just trying to get it back, trying to get my rhythm back again, and to stay as close as possible. And finally it was the right moment, right tactics."

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Follow Howard Fendrich on Twitter at http://twitter.com/HowardFendrich

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  • Roger Federer

    Roger Federer, of Switzerland, wipes his brow late in the fourth set during his loss to Tomas Berdych, of the Czech Republic, in the quarterfinal round of play at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Berdych won 7-6 (1), 6-4, 3-6, 6-3. (AP Photo/Charles Krupa)

  • Tomas Berdych

    Tomas Berdych, of the Czech Republic, raises his arms after defeating Roger Federer, of Switzerland, in the quarterfinal round of play at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012. in New York. Berdych won 7-6 (1), 6-4, 3-6, 6-3. (AP Photo/Charles Krupa)

  • Roger Federer, of Switzerland, watches a replay during a quarterfinals match against Tomas Berdych, of the Czech Republic, at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. Berdych won 7-6 (1), 6-4, 3-6, 6-3. (AP Photo/Darron Cummings)

  • Roger Federer

    Roger Federer, of Switzerland, reacts during a quarterfinals match against Tomas Berdych, of Czech Republic, at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Roger Federer, of Switzerland, reacts during a quarterfinals match against Tomas Berdych, of Czech Republic, at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Roger Federer, of Switzerland, returns a shot against Tomas Berdych, of Czech Republic, during a quarterfinals match at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Tomas Berdych

    Tomas Berdych, of the Czech Republic, pumps his fist after winning the first two sets against Roger Federer, of Switzerland, in the quarterfinal round of play at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Charles Krupa)

  • Roger Federer, of Switzerland, reacts during a quarterfinals match against Tomas Berdych, of Czech Republic, at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Roger Federer

    Roger Federer, of Switzerland, leaves the court after being defeated by Tomas Berdych, of the Czech Republic, in a quarterfinals match at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. Berdych won 7-6 (1), 6-4, 3-6, 6-3. (AP Photo/Darron Cummings)

  • Serena Williams

    Serena Williams hits a return at the net to Ana Ivanovic, of Serbia, during the quarterfinal round of play at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Williams won 6-1, 6-3. (AP Photo/Charles Krupa)

  • Ana Ivanovic

    Ana Ivanovic, of Serbia, serves to Serena Williams during a quarterfinals match at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Serena Williams

    With her hair pulled back in a ponytail, Serena Williams, of the United States, gestures after defeating Ana Ivanovic, of Serbia, 6-1, 6-3 in a quarterfinal at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Charles Krupa)

  • Serena Williams reacts during her quarterfinals match against Ana Ivanovic, of Serbia, at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Williams won 6-1, 6-3. (AP Photo/Darron Cummings)

  • Ana Ivanovic, Serena Williams

    Serena Williams, right, is congratulated by Ana Ivanovic, of Serbia, after Williams defeated Ivanovic 6-1, 6-3 in a quarterfinals match at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Serena Williams

    Serena Williams reacts after defeating Ana Ivanovic, of Serbia, in a quarterfinals match at the U.S. Open tennis tournament on Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Serena Williams

    Serena Williams reacts at the net after missing a return against Ana Ivanovic, of Serbia, during the quarterfinal round of play at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Charles Krupa)

  • Andy Roddick

    Andy Roddick walks onto the court during his quarterfinals match against Argentina's Juan Martin del Potro at the U.S. Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Andy Roddick

    Andy Roddick drops his racket during his match against Argentina's Juan Martin Del Potro in the quarterfinals during the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. (AP Photo/Darron Cummings)

  • Andy Roddick

    Andy Roddick waves to fans after his fourth round loss to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Charles Krupa)

  • Andy Roddick

    Andy Roddick looks up after loosing to Argentina's Juan Martin Del Potro in the fourth round the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Darron Cummings)

  • Andy Roddick

    Andy Roddick salutes fans after his fourth round loss to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Mike Groll)

  • Andy Roddick

    Andy Roddick wipes his face after loosing to Argentina's Juan Martin Del Potro in the fourth round of play at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Mike Groll)

  • Brooklyn Decker

    Andy Roddick's wife, Brooklyn Decker, right, reacts after his fourth round loss to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Charles Krupa)

  • Brooklyn Decker

    Brooklyn Decker, wife of Andy Roddick, reacts after Roddick lost his fourth round match to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Charles Krupa)

  • Andy Roddick

    Fans applaud as Andy Roddick waves after his fourth round loss to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Charles Krupa)

  • Andy Roddick

    Andy Roddick pauses in his chair after his fourth round loss to Argentina's Juan Martin Del Potro at the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Charles Krupa)

  • Andy Roddick

    Andy Roddick reacts after losing to Juan Martin Del Potro in the quarterfinals during the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Darron Cummings)

  • Andy Roddick

    Andy Roddick waves to fans after his loss to Argentina's Juan Martin Del Potro in the quarterfinals during the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Darron Cummings)

  • Andy Roddick, Juan Martin Del Potro

    Andy Roddick, left, greets Argentina's Juan Martin Del Potro after their match in the quarterfinals during the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick, who lost to Del Potro, said he would retire after the match. (AP Photo/Darron Cummings)

  • Andy Roddick

    Andy Roddick speaks to fans after loosing to Argentina's Juan Martin Del Potro in the quarterfinals during the 2012 US Open tennis tournament, Wednesday, Sept. 5, 2012, in New York. Roddick said he would retire after the match. (AP Photo/Darron Cummings)