HEALTHY LIVING
11/05/2012 05:46 pm ET

Double Mastectomy: Sharon Osbourne Undergoes Breast-Removal Surgery Because She Has Breast Cancer Gene

Sharon Osbourne, wife of Ozzy Osbourne and a judge on "America's Got Talent," has announced that she has undergone a preventive double mastectomy because she has the gene that is known to increase risk of breast cancer, Britain's HELLO! magazine first reported.

"As soon as I found out I had the breast cancer gene, I thought: 'The odds are not in my favor,'" Osbourne told HELLO!. "I've had cancer before and I didn't want to live under that cloud: I decided to just take everything off, and had a double mastectomy."

"I didn't even think of my breasts in a nostalgic way, I just wanted to be able to live my life without that fear all the time," the 60-year-old told HELLO!.

Osbourne has survived cancer before, as she was diagnosed with colon cancer 10 years ago, the Associated Press reported.

While Osbourne didn't reveal which breast cancer gene she has, it's well-known that certain harmful mutations of the BRCA1 and BRCA2 genes raise the risk of breast and ovarian cancers. These genes ordinarily work as tumor suppressors, but when they are mutated, they are known to lead to a dramatically raised risk of cancer, the National Cancer Institute reported.

While having the BRCA1 or BRCA2 gene raises risk of breast cancer, it's not a guarantee a woman will get it, CNN reported.

"Patients with BRCA1 or BRCA2 mutations have 50 percent - 85 percent lifetime risk of developing breast cancer and up to approximately 60 percent lifetime risk of ovarian cancer," Karen Brown, the director of the Cancer Genetic Counseling Program at the Mount Sinai School of Medicine, told CNN.

A person can find if he or she has the BRCA1 or BRCA2 genes by undergoing DNA analysis, though the Mayo Clinic noted that only people who have a family history or who have a certain breast cancer type are eligible to receive this test.

Around 5 percent of breast cancer cases are attributed to having inherited the BRCA gene mutation, as are 10 to 15 percent of cases of ovarian cancer, according to the Mayo Clinic.

Osbourne's surgery, called a double mastectomy, involves removal of both breasts.

PHOTO GALLERIES
Celebrities Who Have Faced Breast Cancer

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