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Synthetic Pot Popular Among Teens May Be Linked To Strokes

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This Feb. 15, 2010, photo shows a package of K2 which contains herbs and spices sprayed with a synthetic compound chemically similar to THC, the psychoactive ingredient in marijuana. State lawmakers in Missouri and Kansas have introduced bills which would create penalties for K2 possession similar to those for marijuana.(AP Photo/Kelley McCall) | ASSOCIATED PRESS

A synthetic marijuana popular among teens may cause strokes, a University of Southern Florida study found.

USF Neurologists published news of the possible link in the journal Neurology after a brother and sister, 26 and 19, suffered acute ischemic strokes shortly after smoking the synthetic marijuana street drug known as "spice" or K2. The researchers ruled out any undiagnosed genetic condition that would predispose the siblings to strokes at such a young age.

“We rigorously looked for those and didn’t come up with anything,” senior study author W. Scott Burgin said. “To the best of our knowledge, what appeared to be heart-derived strokes occurred in two people with otherwise healthy hearts. So more study is needed.”

Burgin told the Tampa Bay Times that since submitting to the journal, he has seen two more cases of stroke in unrelated patients that were likely spice-induced.

Banned in 43 states and undetectable in toxicology screenings, spice is made of a mixture of herbs doused in “a solution of designer chemicals” that mimic a cannabis high when consumed. But Burgin warned that the synthetic drug can be even more potent than real marijuana because of the more complete way its psychoactive ingredient binds to the brain’s cannabinoid receptors.

“You don’t know what you’re getting when you smoke synthetic marijuana,” Dr. Burgin said of the product sold mostly underground and without any ingredients list. “It’s like the Wild West of pharmaceuticals, and you may be playing dangerously with your brain and your health.”

This isn’t the first time synthetic marijuana has been linked to serious health risks. A study in February out of the University of Alabama at Birmingham linked the product to acute kidney injury.

In spite of the risks, the synthetic cannabis is immensely popular among teens. A 2011 survey conducted by the National Institute on Drug Abuse found that second to only real marijuana, it was the most used illicit drug among high school seniors.

While the chemical similarities between synthetic and real pot remain unclear, the study’s findings may inspire researchers to continue research into real marijuana’s possible link to strokes. A study out of New Zealand in February reported a possible increased risk of stroke from cannabis use, but the findings were widely considered inconclusive because the researchers did not control for tobacco use, which doubles the risk of stroke.

“In any event, if marijuana can cause ischemic stroke, and if anything pot can do spice can do better, neurologists will likely encounter increasing numbers of spice-associated strokes in the years ahead,” said Columbia University neurology professor John C. M. Brust.

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