Wellnesshealthy livingreutersebola vaccine

Ebola Vaccine Results Are 'Very Satisfactory' So Far

Promising New Ebola Vaccine Tested On 200 People So Far
Reuters
Press record as a volunteer gets an injection of an Ebola vaccine called ChAd3 as part of trials on November 4, 2014 at the CHUV hospital in Lausanne.ￃﾂￂﾠMost of the 120 volunteers will receive the experimental vaccineￃﾂￂﾠmade by Britain's GlaxoSmithKine,ￃﾂￂﾠwhich is based on a genetically modified chimpanzee adenovirus, but some of them will receive a placebo. ￃﾂￂﾠ ￃﾂￂﾠAFP PHOTO / Richard Juilliart (Photo credit should read Richard Juilliart/AFP/Getty Images)
Press record as a volunteer gets an injection of an Ebola vaccine called ChAd3 as part of trials on November 4, 2014 at the CHUV hospital in Lausanne.ￃﾂￂﾠMost of the 120 volunteers will receive the experimental vaccineￃﾂￂﾠmade by Britain's GlaxoSmithKine,ￃﾂￂﾠwhich is based on a genetically modified chimpanzee adenovirus, but some of them will receive a placebo. ￃﾂￂﾠ ￃﾂￂﾠAFP PHOTO / Richard Juilliart (Photo credit should read Richard Juilliart/AFP/Getty Images)

By Kate Kelland

LONDON, Nov 17 (Reuters) - Almost 200 people have received GlaxoSmithKline's experimental Ebola vaccine in trials in the United States, Britain, Mali and Switzerland, and the safety data so far are "very satisfactory," scientists said on Monday.

The trials, which began just over two months ago, have been using healthy volunteers, rather than patients with Ebola, to test whether the vaccine is safe for humans.

The experimental shot uses a single Ebola virus gene from a chimpanzee virus to generate an immune response. Because it doesn't contain any infectious virus material, it can't infect those being vaccinated.

Adrian Hill, a professor at Oxford University who is leading the British arm of the trial, said 20 people at the U.S. National Institutes of Health in Bethesda, Maryland, 80 people at the University of Maryland School of Medicine Center for Vaccine Development in Mali, 34 people out of an eventual 120 at the University Hospital of Lausanne, and 59 out of an eventual 60 at the University of Oxford had so far been given the shot.

"The safety data here have looked very satisfactory so far," Hill said in a statement. "The response we have seen from people coming forward to take part has been remarkable."

The West Africa Ebola epidemic has now infected more than 13,000 people -- mainly in Guinea, Sierra Leone and Liberia -- and killed more than 5,000 of them, according to the World Health Organization (WHO).

Several drug companies are now accelerating Ebola vaccine trials and the WHO has said it hopes one or more of the vaccines may be ready for some limited use in West Africa in early 2015.

GSK's vaccine and another leading candidate made by NewLink Genetics are already in human trials. Five more should begin testing in the first quarter of next year, according to the WHO. One from Johnson & Johnson will start trials in January.

Hill said the teams running the GSK vaccine trial should know by late December 2014 how the immune responses of Malian health care workers who have had the shot compare to those observed in adults given the vaccine in Britain and Switzerland. (Reporting by Kate Kelland; Editing by Andrew Heavens)

Related

healthy livingreutersebola vaccineebola-vaccine-testing

Before You Go

1
Ebola is highly infectious and even being in the same room as someone with the disease can put you at risk
ASSOCIATED PRESS
Not as far as we know. Ebola isn't contagious until symptoms begin, and it spreads through direct contact with the bodily fluids of patients. It is not, from what we know of the science so far, an airborne virus. So contact with the patient's sweat, blood, vomit, feces or semen could cause infection, and the body remains infectious after death. Much of the spread in west Africa has been attributed to the initial distrust of medical staff, leaving many to be treated at home by loved ones, poorly equipped medics catching the disease from patients, and the traditional burial rites involving manually washing of the dead body. From what we know already, you can't catch it from the air, you can't catch it from food, you can't catch it from water.
2
Cancelling all flights from west Africa would stop the spread of Ebola
ASSOCIATED PRESS
This actually has pretty serious implications. British Airways suspended its four-times-weekly flights to Liberia and Sierra Leone until the end of March, the only direct flight to the region from the UK. In practice, anyone can just change planes somewhere else and get to Britain from Europe, north Africa, or the Middle East. And aid agencies say that flight cancellations are hampering efforts to get the disease under control, they rely on commercial flights to get to the infected regions. Liberia's information minister, Lewis Brown, told the Telegraph this week that BA was putting more people in danger. "We need as many airlines coming in to this region as possible, because the cost of bringing in supplies and aid workers is becoming prohibitive," he told the Telegraph. "There just aren't enough seats on the planes. I can understand BA's initial reaction back in August, but they must remember this is a global fight now, not just a west African one, and we can't just be shut out." Christopher Stokes, director of MSF in Brussels, agreed: “Airlines have shut down many flights and the unintended consequence has been to slow and hamper the relief effort, paradoxically increasing the risk of this epidemic spreading across countries in west Africa first, then potentially elsewhere. We have to stop Ebola at source and this means we have to be able to go there.”
3
Temperature screening at airports is an effective way to stop those who have the disease from travelling
ASSOCIATED PRESS
The screening process is pretty porous, especially when individuals want to subvert it. Wake up on the morning of your flight, feel a bit hot, and you definitely don't want to be sent to an isolation booth for days and have to miss your flight. Take an ibuprofen and you can lower your temperature enough to get past the scanners. And if you suspect you have Ebola, you might be desperate to leave, seeing how much better the treatment success has been in western nations. And experts have warned that you cannot expect people to be honest about who they have had contact with. Thomas Eric Duncan, the Ebola victim who died in Texas, told officials he had not been in contact with anyone with the disease, but had in fact visited someone in the late stages of the virus, though he said he believed it was malaria. The extra screening that the US implemented since his death probably wouldn't have singled out Duncan when he arrived from hard-hit Liberia last month, because he had no symptoms while travelling.
4
Border staff should stop people coming in to the country who are at risk
LEON NEAL via Getty Images
They're not doctors, and it's a monumental task to train 23,500 people who work for the UK Border Agency how to correctly diagnose a complex disease, and spot it in the millions of people who come through British transport hubs. Public Health England has provided UK Border Force with advice on the assessment of an unwell patient on entry to UK, but they can't be expected to check everyone.
5
Screening at British airports should be implemented to stop unwell people coming in from affected areas
ASSOCIATED PRESS
As mentioned before, the UK, especially London, is a major transport hub. Unlike the US, most of those coming from west Africa will have crossed through Europe, so infected people could be coming from practically anywhere, not just flights directly from those countries. This would require the UK to screen every returning traveller, as people could return to the UK from an affected country through any port of entry. This would be huge numbers of low risk people, at vast, vast expense.
|
Submit a tip

Popular in the Community

Close

HuffPost Shopping’s Best Finds

MORE IN LIFE