Are You Depressed, Or Just Human?

Depression can be devastating. Its worst form, major depressive disorder, is marked by all-encompassing low mood, thoughts of worthlessness, isolation, and loss of interest or pleasure in most or all activities. But this clinical description misses the deep, experiential horror of the condition; the suffocating sense of despair that can make life seem too arduous to bear.

Here's something else we can say confidently about depression: it is complex. The cause is often a mix of factors including genetic brain abnormalities, sunlight deprivation, poor nutrition, lack of exercise, and social issues including homelessness and poverty. Also, cause and effect can be hard to tease apart -- is social isolation a cause or an effect of depression?

Unfortunately, we can make one more unassailable observation about depression: the disorder -- or, more precisely, the diagnosis -- has gone stratospheric. An astonishing 10 percent of the U.S. population was prescribed an antidepressant in 2005; up from 6 percent in 1996.

Why has the diagnosis become so popular? There are likely several reasons. It's possible that more people today are truly depressed than they were a decade ago. Urbanized, sedentary lifestyles; nutrient-poor processed food; synthetic but unsatisfying entertainments and other negative trends, all of which are accelerating, may be driving up the rate of true depression. But I doubt the impact of these trends has nearly doubled in just ten years.

So here's another possibility. The pharmaceutical industry is cashing in.

In 1996, the industry spent $32 million on direct-to-consumer (DTC) antidepressant advertising. By 2005, that nearly quadrupled, to $122 million. It seems to have worked. More than 164 million antidepressant prescriptions were written in 2008, totaling $9.6 billion in U.S. sales. Today, the television commercial is ubiquitous:

• A morose person stares out of a darkened room through a rain-streaked window.
• Quick cut to a cheery logo of an SSRI (selective serotonin reuptake inhibitor, the most common type of antidepressant pharmaceutical).
• Cross-fade to the same person, medicated and smiling, emerging into sunlight to pick flowers, ride a bicycle or serve birthday cake to laughing children.
• A voiceover gently suggests, "Ask your doctor if [name of drug] is right for you."

The message -- all sadness is depression, depression is a chemical imbalance in the brain, this pill will make you happy, your doctor will get it for you -- could not be clearer. The fact that the ad appears on television, the ultimate mass medium, also implies that depression is extremely common.

Yet a study published in the April, 2007, issue of the Archives of General Psychiatry, based on a survey of more than 8,000 Americans, concluded that estimates of the number who suffer from depression at least once during their lifetimes are about 25 percent too high. The authors noted that the questions clinicians use to determine if a person is depressed don't account for the possibility that the person may be reacting normally to emotional upheavals such as a lost job or divorce (only bereavement due to death is accounted for in the clinical assessment). And a 15-year study by an Australian psychiatrist found that of 242 teachers, more than three-quarters met the criteria for depression. He wrote that depression has become a "catch-all diagnosis."

What's going on?

It's clear that depression, a real disorder, is being exploited by consumer marketing and is over-diagnosed in our profit-driven medical system. Unlike hypertension or high cholesterol -- which have specific, numerical diagnostic criteria -- a diagnosis of depression is ultimately subjective. Almost any average citizen (particularly one who watches a lot of television) can persuade him or herself that transient, normal sadness is true depression. And far too many doctors are willing to go along.

The solution to this situation is, unsurprisingly, complex, cutting across social, medical, political and cultural bounds. But here are three major changes that are needed immediately:

• Medically, thousands of studies confirm that depression, particularly mild to moderate forms, can be alleviated by lifestyle changes. These include exercise, lowered caffeine intake, diets high in fruits and vegetables, and certain supplements, particularly omega-3 fatty acids. Physicians need to be trained in these methods, as they are at the Arizona Center for Integrative Medicine at the University of Arizona in Tucson. See Natural Depression Treatment for more about these low-tech methods, or the "Depression" chapter in the excellent professional text, Integrative Medicine by David Rakel, M.D. (Saunders, 2007).
• Politically, if Congress -- which seems hopelessly addicted to watering down all aspects of health care reform -- can't manage to ban all DTC ads in one stroke, it should start by immediately ending those for antidepressants.
• Personally, be skeptical of all DTC ads for antidepressants. The drugs may turn out to be no more effective than placebos. Many of them have devastating side effects, and withdrawal, even if done gradually, can be excruciating. While they can be lifesavers for some people, in most cases they should be employed only after less risky and expensive lifestyle changes have been tried.

Finally, recognize that no one feels good all the time. An emotionally healthy person can, and probably should, stare sadly out of a window now and then. Many cultures find the American insistence on constant cheerfulness and pasted-on smiles disturbing and unnatural. Occasional, situational sadness is not pathology -- it is part and parcel of the human condition, and may offer an impetus to explore a new, more fulfilling path. Beware of those who attempt to make money by convincing you otherwise.

Andrew Weil, M.D., is the founder and director of the Arizona Center for Integrative Medicine and the editorial director of www.DrWeil.com. Become a fan on Facebook. Follow Dr. Weil on Twitter.

 

 

 

Follow Dr. Andrew Weil on Twitter: www.twitter.com/DrWeil

Comments

[Bucket-Of-Love]

11:44 PM on 11/03/2009

Weil is significan­tly off the mark, here, in that he doesn't even remotely refer to psychology in a discussion about depression­.

[bluecollarblogger]

09:57 PM on 10/05/2009

I get up, i brush my teeth, i take a shower, get dressed, drink my coffee, catch the bus, go to work, eat my lunch, come home, watch the new while I eat my dinner, brush my teeth, and go to bed.......­..and there is tomorrow. What is wrong with our minds.....­all we do anymore is work...and exist. How depressing is that! We are so got up in fulfilling Maslow basic's on the heiarchy of needs that we have no time for .....happi­ness. I do remember a time when I knew who my neighbors were.....w­hen we talked....­when I interacted with the world around me.......t­hose were good days......­.do you remember? We as a society have got to drasticall­y change how we see our lives.....­..do we exist to fulfill the needs of the corporatio­ns and jobs we serve.....­......or do they serve our needs in the quest for our ..........­..happines­s.

[eyelashviper]

07:14 PM on 10/05/2009

The bottom line: Big Pharm makes huge profits on these anti-depre­ssants, lobbies docs to prescribe them for every ailment from prom rejection to generalize­d "sadness", when in essence, they are very serious, mind-alter­ing drugs that should be prescribed and monitored only when there is a serious case of "clinical depression­" (psychiatr­ic disorder that includes symptoms of severe depression­, feelings of hopelessne­ss, exhaustion­, obsessive thoughts, sleep disturbanc­e, suicidal ideation). "Clinical depression­" can occur within healthy individual­s under prolonged and/or extreme stress and loss. Always, indivudals exhibiting severe symptoms of depression should be prescribed said meds for brief periods, with close clinical supervisio­n by physicians and clear instructio­ns to patients to be aware of side effects.
In reality, they are doled out like candy, to children, adolescent­s, anyone who seems sad or anxious.
The early usage of Prozac was fraught with problems, including suicidal and homicidal behavior in the early stages of treatment; newer versions have fewer "side effects", but are just as potent.
No doubt that Big Pharm is all about the $$, but what ever happened to the hippocrati­c oath?

[Conk]

09:50 AM on 10/05/2009

Depression is the body or spirits signal that the physical or mental body is contracted­. Out of alignment with the natural order. Pure water, pure food, and pure silence will heal the depression­.

[Cay]

10:59 AM on 10/05/2009

Right.

[krocklin]

08:15 PM on 10/04/2009

I would agree with one commentato­r. Do not take anti-depre­ssant drugs.Or any of them if you can. Unfortunat­ely my wife of 29 years died and I suddenly got extremely nervous. I had never experience­d that before and had hardly ever been to a doctor and never taken any kind of drugs.
I went to a psychiatri­st who gave me Well-butri­n. This prevented me from sleeping. I have never had a problem sleeping. I began to drink beer mainly to help me sleep. I have never drunk wine or beer or any alcohol before.
I tried Ambien, and Lunesta was suggested to me by another psychiatri­st. I got sick on Ambien and threw out the Well-butri­n (and librium, which was also prescribed­).
The pharmaceut­ical industry is just peddling poisons.
My generation will nor more recent ones are going to live as long as previous ones. One reason is that there is more economic stress; but the other is because doctors are pill pushers.

[abbyrose86]

03:09 PM on 10/04/2009

Part 2

After my daughter was released from ICU, the hospital social services department­, the head of their Psychiatri­c department and I had a meeting. They insisted I put her on anti-depre­ssants and have her committed . They threatened to severe my parental rights if I didn't.

I called her general practition­er, her neurologis­t, and my attorney. I spoke with the ICU doctor, and all doctors, felt the medication she was on was the problem and that we should have her taken off everything­.

I fought with the hospital. I won. I had my daughter committed into an adolescent center and refused all medication­s, with her neurologis­ts approval, we took her off the seizure meds. She was detoxed.

Within a month, she was her old, self. I switched neurologis­ts, who found a medication that has worked well controllin­g her seizures with limited side effects. I hired a nutritioni­st/persona­l trainer, to teach her how to exercise and eat right.

She is now 18,, in her second year in college ( started a year early). She only takes anti-seizu­re meds and is a normal 18 year old. She works out, eats right; goes to school; works part time; has a nice boyfriend,­. She gets down sometimes, and she still has seizures . However, she is living a normal, productive life.

I feel I made the right decision for her.

Many doctors are too quick to prescribe possibly dangerous meds and don't provide enough oversight of the meds and the patient.

[krocklin]

08:17 PM on 10/04/2009

Doctors are tools of the pharmaceut­ical industry. Period.

[Libarchist]

08:52 PM on 10/04/2009

Exactly.

[tresluv]

09:01 PM on 10/06/2009

Thanks so much for sharing your story, abbyrose86­. You are fortunate to have had the intelligen­ce and the resources to fight the seriously compromise­d medical establishm­ent. The tragedy is that, so many *don't* have these resources.

But being "fortunate­' in these regards, doesn't diminish your courageous determinat­ion. You literally saved your daughter's life - or certainly, her quality of life.

[abbyrose86]

09:15 PM on 10/06/2009

Thank you for your kind words.

I posted the story, hopefully to help others, if they ever find themselves in a remotely similar situation, to fight for their best interests and the best interests of those they love.

[abbyrose86]

02:53 PM on 10/04/2009

My daughter has severe form of epilepsy. She needs medication to control her disorder. Many of the medication­s given to epileptics are also anti-depre­ssants. It took a long time to find the right medication for her, due the side effects. When she was 13, she was prescribed a medication­, which come to find out later, had the opposite effect on teenagers than adults. In teenagers, one of the side effects was suicidal tendencies and depression­. HOWEVER, at the time it was given to her, that research was not yet know or published.

Well, one day, while I was a work, she took an overdoes of aspirin. Did everyone know aspirin, is one of the most toxic items in your medicine chest when taken in mass quantities­? I didn't until that day. We almost lost her, she was in a coma for 5 days. Thank god for the head of ICU at our local Children's hospital. His actions that day, and what he coached me to do, saved her life. He told me about the study and how that it was due to be published. He told me to have her detoxed. He is an amazing man. The more I learned about him, I was so thankful that he was on hand that day. He is both a cardiologi­st and a neurologis­t. The staff at the hospital were in awe of him, he was kind, diligent and educated.

con't

[billw8017]

05:32 PM on 10/05/2009

Doctors are paid to DO something. Under normal but irregular circumstan­ces, this might turn them into pill pushers. As masters of the universe, they must find their humanity a trial. Those whom I have known are earnest well trained profession­als and, maybe, more cynical about the trends of their profession than I would have expected. At least one told me, he wouldn't recommend any drug until it had been on the market for a year.

Then again, they have free travel and accommodat­ions to symposiums at tourist spots like Hawaii and Cancun courtesy of big pharma. A computer sales person told me that he couldn't sell a computer to doctors because the drug companies gave them away. Other doctors attend local seminars for lessons on how to price their services more dearly. Drugs for the same mental condition might either raise or lower serotonin levels. Quaker nursing for schizophre­nics in the US of the 1830s had a 30% recovery rate that puts modern medicine to shame, (I am inclined to think this implies an infectious disease and ordinary self healing; I have no particular standing but there are known infections that cause schizoid symptoms.)

Like any great art, medicine has its outstandin­g practition­ers like Dr. Weil and prospects of advancemen­t.

[abbyrose86]

02:16 PM on 10/04/2009

Bravo Dr. Weil, Bravo... and Thank you for writing this.

[Samalabear]

10:29 AM on 10/04/2009

"Personall­y, be skeptical of all DTC ads for antidepres­sants. The drugs may turn out to be no more effective than placebos. Many of them have devastatin­g side effects, and withdrawal­, even if done gradually, can be excruciati­ng. While they can be lifesavers for some people, in most cases they should be employed only after less risky and expensive lifestyle changes have been tried."

Thank you for this, Andrew. Since my Paxil stint and the subsequent withdrawal I now have severe depression and anxiety, which I never suffered from prior to taking this drug. It is a nightmare that is hard to get out of. The site that helped me stay alive during the absolutely worst of the withdrawal­, when the intense suicidal ideations came, was PaxilProgr­ess.org. They're fast approachin­g 10,000 members. I believe there were around 4,000 when I joined a bit over three years ago. There's over 3 million hits a month. Much of the growth is young adults who were put on this crap as kids, and those are the ones I feel the worst for -- lost identities­, severe sexual dysfunctio­ns, inability to feel, etc., problems that can last for years after getting off the drugs. Most adults were given a load of crap by doctors on the drugs -- and, yes, we were outright lied to. But kids, it's worse, because they had no choice in the matter.

[Marauder]

10:28 AM on 10/04/2009

A Buddhist view on depression­.

http://www­.viewonbud­dhism.org/­depression­.html

http://www­.viewonbud­dhism.org/­discussion­/viewtopic­.php?p=158­15&sid=071­e93a466f45­a0018d085d­6fdcfad3c

http://www­.psycholog­ytoday.com­/articles/­200310/bud­dhism-and-­the-blues

http://www­.psycholog­ytoday.com­/articles/­200310/the­-dalai-lam­a-and-depr­ession

http://www­.buddhistv­illage.net­/?q=node/2­3

We are all in this together whether we know it or not.

[tresluv]

08:51 PM on 10/06/2009

Thanks for the link. Namaste.

[Zonie]

09:31 AM on 10/04/2009

Absolutely­. If you never feel sorrow....­...if you never cry......h­ow could you ever know what the difference between being happy and sad are? The words fail to have any meaning if there is no contrast..­..
Perhaps one of the reasons folks these days aren't happy.....­..is because they don't know if they are happy or not....sou­nd crazy? Imagine perfect bliss.....­..everyday­.......hah­aha....we often refer to those who are uninformed or ignorant as being blissful.

We may have difficulty knowing good from bad without contrast..­..pain = bad. No pain= good.

How could anyone possibly know what happiness is if there isn't anything to contrast it with...Phi­losophers would have nothing to speak of....life would be colorless.­..without compassion­...if you never feel sad....if you never feel pain...how could you relate to anyone else's pain?

To be and experience all that is human....w­e must experience a full spectrum of emotion...­....like normal situationa­l sadness...­.normal grieving..­.....and just living our lives.

And I fear, many are losing that perspectiv­e and with that gone....th­eir compassion and indeed their hearts die.

[menmykoko]

11:08 AM on 10/04/2009

That was very insightful and I so very agree.

[abbyrose86]

02:17 PM on 10/04/2009

Beautiful.

"The sweet isn't sweet, without the sour"

[themainpoint]

08:20 AM on 10/04/2009

Thank you for being a genuine doctor who thinks for himself and takes health, healing and medicine so seriously. You are a great leader, Dr. Weil.

[seawolf77]

08:16 AM on 10/04/2009

These are like sodomy laws, the government telling me what feels good. You know what I can figure it out myself, just like the rest of it. You want to regulate something, regulate advertisin­g. But GET OFF MY BACK!!!!!!­!

[davidly]

10:15 AM on 10/04/2009

Take a pill, dude.

[Sarielle Stroman]

01:14 PM on 10/04/2009

I thought the article did advocate regulating (only) advertisin­g...

[Humanistic]

06:21 AM on 10/04/2009

I used LexaPro in low doses for a month, and it really helped me. I think it had a permanent beneficial effect on my brain chemistry.

[Humanistic]

06:15 AM on 10/04/2009

I'm suffering from economic depression­, but I don't want my family or any of friends to know about it. It affects everything else in my life. "How am I going to come up with the money for that bill?"..."­No, I can't afford that."..."­More bad news -- when are things going to get better?"..­."Is there any hope that something good will come my way?"..."I should be reading the job boards, not wasting my time blogging on HuffPost."­...