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Dr. Andrew Weil

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Carbohydrate Density: A Better Guide to Weight Loss

Posted: 10/11/2012 9:00 pm

On its surface, the cause of the Western world's obesity epidemic seems simple: People are eating too many calories and getting too little calorie-burning exercise; the imbalance manifests as excess fat.

But this explanation is too simple. Even low-calorie diets and vigorous exercise fail to work in the long term for at least some people.

Here's why: Exercise, while vital to good health, is a poor exclusive means of weight control. Excess exercise tends to be counterbalanced by excess hunger, exemplified by the phrase "working up an appetite." A few people with extraordinary willpower can resist such hunger day after day, but for the vast majority, weight loss through exercise is a flawed option.

Meanwhile, simply cutting back on total calories is fraught with peril as well. An excellent study by Harvard University researchers confirms that the kinds of foods one eats -- rather than total calories per se -- is the most important indicator of whether a given eating pattern leads to weight gain or loss.

So what's the best way of eating to manage weight? Fortunately, some answers are emerging.

Increasingly, chronic, inappropriate inflammation is widely recognized as a driver of obesity. Inflammation in the body is a normal and healthy response to injury or attack by germs. We can see it, feel it and measure it on the surface as local heat, redness, swelling, and pain. This is the body's way of getting more nourishment and more immune activity into an area that needs to fend off infection or heal. But whole-body, elevated inflammation -- as evidenced by increased levels of certain protein markers in the blood -- has actually been shown to predict future weight gain in a study of non-diabetic healthy men. Inflammation, in short, helps make you fat.

Obesity, in turn, promotes chronically elevated inflammation. As this Harvard review article puts it, "A chronic, subacute state of inflammation often accompanies the accumulation of excess lipid in adipose tissue and liver (hepatic steatosis), evidenced by changes in both inflammatory cells and biochemical markers of inflammation."

In other words, obesity and inflammation feed each other in a destructive cycle. This may help explain why weight, once gained, can be so difficult to lose.

Which brings me to a fascinating new paper by Ian Spreadbury of the Gastrointestinal Diseases Research Unit at Queen's University in Ontario, Canada. It provides what I believe could -- and probably should -- become the dominant index for deciding which foods to eat and which to avoid in pursuit of weight control. Bearing the daunting title, "Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity," the paper lays out the hypothesis that carbohydrate density is probably the most important determinant of whether a food promotes inflammation/obesity or not.

Carbohydrate density is simple to calculate -- just divide the quantity of carbohydrate in food by the weight of the food. The more carbs that are packed into a given gram of food, the higher its carbohydrate density.

Modern food processing is, unfortunately, very good at boosting carbohydrate density. Two of the most powerful ways to do it are isolating and concentrating sugars from plants, and grinding dense seeds into highly compactible flour. In both cases, heat and pressure damage or obliterate the original food's cell walls. To use Spreadbury's terminology, sugar and flour are acellular -- almost wholly lacking in intact cells.

According to Spreadbury's review, these carbohydrate-dense, acellular foods may help to make the normal, natural bacteria that inhabit the digestive tract become pro-inflammatory. One destructive consequence: these inflammation-promoting microbes produce "leptin resistance in vagal afferent endings"; in other words, a blunting of the ability of leptin and other hormones that say "I've eaten enough" to communicate that message to the brain via nerve endings in the gut.

This matters, as virtually every physician who counsels obese patients hears the refrain, "I just never feel full!" Such complaints should not be dismissed as fanciful -- it's quite possible that people with inflamed GI tracts really do wrestle with more or less continuous, unquenchable feelings of hunger, making weight loss far more difficult than it should be.

If Spreadbury is right, the obesity solution is straightforward. I'll discuss that, and list specific high- and low-density carbohydrate foods, in "Using the Carbohydrate Density Index."

Andrew Weil, M.D., is the founder and director of the Arizona Center for Integrative Medicine and the editorial director of www.DrWeil.com. Become a fan on Facebook, follow Dr. Weil on Twitter, and check out his Daily Health Tips Blog.

Dr. Weil's latest book, "TRUE FOOD: Seasonal, Sustainable, Simple, Pure," publishes on October 9th, 2012.

For more by Dr. Andrew Weil, click here.

For more on weight loss, click here.

 
 
 

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On its surface, the cause of the Western world's obesity epidemic seems simple: People are eating too many calories and getting too little calorie-burning exercise; the imbalance manifests as excess f...
On its surface, the cause of the Western world's obesity epidemic seems simple: People are eating too many calories and getting too little calorie-burning exercise; the imbalance manifests as excess f...
 
 
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01:17 AM on 11/04/2012
Great post Mr. Weil! Many people struggle with weight loss 'in the long run' because they haven't established a way to implement a healthy diet AND exercise. In fact, this is exactly why I created NXFIT (www.nxfit.com). I realized people had real trouble not only sticking to a fun and convenient exercise program but also maintaining a healthy diet.
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jf12
When I saw her I marveled greatly.
04:40 PM on 10/15/2012
More salads, fewer french fries.
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FaunaAndFlora
Daughter of Pan
12:59 AM on 10/16/2012
More meat, eggs and full-fat dairy served with lots of vegetables while cutting back on breads, pastas, cookies, cakes and pies.
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Yogamum
Nature girl
03:55 PM on 10/15/2012
Dr. Weil, please publish an article regarding the connection between red meat and inflammation. Many of the posters are interpreting this article as confirmation of their high meat/high protein diets. They are confusing processed carbs with whole carbs and lumping all carbs in the same "bad" category.
04:48 PM on 10/15/2012
I don't think anyone is confusing carbohydrate content here. It is well known that most meats have 0 carbohydrate. Too much protein can indeed cause inflammation, but the color of the food is not a very scientific reasoning behind inflammation. Especially when the study I believe you are referring to combines processed meat (which is often eaten between two slices of bread) and steak in the same category.
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FaunaAndFlora
Daughter of Pan
01:12 AM on 10/16/2012
A connection doesn't mean there is a cause. Correlation doesn't equal causation. And the correlation between red meat and inflammation isn't statistically significant. On the other hand, it has been known that wheat has a statistically significant association with inflammation for the last sixty to seventy years. For some reason, this continues to be ignored. Perhaps this is because of lobbyist who work for the cereal companies Kellogg's, Post, General Mills, Quaker Oats).
HUFFPOST SUPER USER
2Paco
Vegan and loving it!
09:51 AM on 10/16/2012
I recommend a website you might find interesting. Look under browse topics for information on specific studies. There is quite a bit on meat consumption and inflammation.

Nutritionfacts.org

Excellent site.
06:26 AM on 10/15/2012
I just have to weigh in here.... I am now a proponent of the autoimmune paleo eating plan. Diet is a bad word. To me it means restriction and we all want to break the rules, right? It's been an easy elimination of inflammatory foods, sugars and grains. I've lost weight. I don't know how much. I just know I look better in addition to feeling better. If you've ever felt as miserable as I have (from guillain barre syndrome), you might just be willing to make the shift in your life that will bring life back to you. Make sustainable choices. Don't do it all at once. Pick one thing at a time to either eliminate or include and build on it.

More importantly, teach your kids. Model better choices so they don't get caught up in the frenzy of diets and bad carbs. We spend more time teaching them about stranger danger than we do about healthy eating choices.
09:23 AM on 10/16/2012
You have my sincerest sympathies if you have endured the hardship of Guillain-Barre...I have nursed more than one person through that horrific ordeal. You have nothing but my very very dearest and best wishes to carry with you throughout you life.
02:29 AM on 10/15/2012
Part of the problem is the relentless search for ways to solve weight problems without making uncomfortable sacrifices. Be it simple hunger or the discomfort of changing one's favored eating patterns, though, caloric restriction of any kind is likely to involve uncomfortable sacrifices. If nothing else, we've gotten used to the way we do things, and any change is a challenge.

Key, then, may be not trying to find a way of eating we don't like, but learning to make small sacrifices gracefully. The first ones are often the hardest -- just getting in the mind-set to give things up. It can seem that life asks us to drop one pleasure after another until we have too few left. But except for people with disease conditions who already have to eat in very particular ways, we all have at least a few indulgences we can drop fairly painlessly, and at least a few more we could drop without too much effort lasting too long. You get used to it in time.

The problem is one of lifestyle, not diet. As an adult, you have to make compromises with the world. Controlling one's diet is just one more.

On a similar tack, I've known a lot of people who try to eat like a child when they've already settled into adult metabolisms. No can do, friend. Life changes, and you have to change too. It's not suffering. It's just life.
09:26 AM on 10/16/2012
The sacrifices involved are about which foods we will eat. That is all.
10:58 PM on 10/14/2012
Interesting article, but Dr. Weil needs to follow his own advice, his BMI is high you know!!
ThinkCreeps
Seriously, it's time.
02:54 AM on 10/15/2012
It's all beard.
10:29 PM on 10/14/2012
Atkins was right.
09:26 AM on 10/16/2012
Yes. He was.
foresure
Brash and Harsh
05:35 PM on 10/14/2012
Many years ago, as a teaser before a commercial, Kieth Oberman said he was going to reveal the secret of permanent weight loss.

"Eat less, excercise more".
09:27 AM on 10/16/2012
Of course that incorrect advice is not a secret. And no matter how ANYONE spins it INCLUDING Keith Olbermann, it is still bad advice, more proven to increase weight than to reduce it.
foresure
Brash and Harsh
01:56 PM on 10/16/2012
Alvarask:

A calorie is measure of energy.
foresure
Brash and Harsh
05:33 PM on 10/14/2012
In Graham Greene's novel about Haiti, one of the characters is an American who had run for President on the vegetarian ticket, one of the characters remarks, "there are plenty of vegetarians in Haiti, but not by choice".

Not too many obese people either.
09:28 AM on 10/16/2012
Do you have a point in there? Long term malnutrition? Is that your recommendation for improving health?
foresure
Brash and Harsh
01:57 PM on 10/16/2012
Alvarask:

Exactly unless you consume more calories than you expend, you will surely die of starvation.
04:26 PM on 10/14/2012
FABULOUS article and supporting links to your data. I always incorrectly assumed you supported conventional wisdom (high carb, kill yourself with exercise). Keep getting the word out! Chronic exercise cannot fix the refined carb imbalance that is causing rampant obesity. Bravo!
09:29 AM on 10/16/2012
Nice post! Allow me the honour of being your first fan. Faved as well. Of course.
02:58 PM on 10/16/2012
Thank you!
03:20 PM on 10/14/2012
I went to Dr Weil's website for continued reading on this topic. I was surprised to see paid advertising from Pizza Hut. Last time I ate (or started to to eat) one of their pizzas the salt hit burned out the tastebuds on the first bite. Needed a couple of Anhauser buds to rinse it away. Did I mention the grease?
09:30 AM on 10/16/2012
Thank god for the buds eh?
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herdingcats2012
Trying to Control the Uncontrollable
02:47 PM on 10/14/2012
It's interesting to see this "connection" being raised between chronic inflammation and obesity. I observed this precise relationship when I recently went on an "elimination diet" in an attempt to identify suspected food sensitivities.

When all of the most common "suspects" were removed (gluten, dairy, beef, wheat, whole grains, chocolate, caffeine, eggs, and food additives) I lost about 7 lbs. within the first week. Caloric restriction and excercise would not yield that amount of weight loss. Once the "inflammation" was reduced my weight loss continued--but, more in line with a traditional calorie restrictive diet (about 1-2 lbs per week).

The "elimination" diet doesn't provide access to the level of "variety" of food choices to provide the proper nutritional support--and since it largely identified the obvious food sensitivities associated to the symptoms I was dealing with, I stopped after only 5 weeks.

My new question--is there a correlation between the use of a "natural gas" stove, inflammation, and weight gain). I suspect for me personally this relationship exists--I am just at a loss as to how to observe it without going through the significant cost of replacing my natural gas range with an electric one.
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Yogamum
Nature girl
03:47 PM on 10/15/2012
I don't see how a gas stove would effect the food since it is burned off. Gas ranges are better for cooking on (they are what professional chefs use) and are less expensive to use then electric.
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herdingcats2012
Trying to Control the Uncontrollable
04:50 PM on 10/15/2012
It's not getting into the food--it's getting into the air I breath as it's being burned off--particularly the oven. I experience typical allergic "chemical exposure" symptoms--inflammation of face, hands, nose, throat, and lungs; along with headaches, dizziness, fatigue, and mental confusion if I remain in the same room as my gas oven when it is operating for an extended period of time.
 
Inflammation is traditionally the result of a hyper or chronic immune system response. This is the focus on my current "observatory" endeavor.
 
 
 
09:33 AM on 10/16/2012
You pose an interesting question. From a cooking perspective natural gas is great. But gas in the air is a whole other thing. There's no question that the whole issue is based in inflammation, no matter how much people of various ideologies fight against it. I don't have an answer to your question, but I may look at that electric coil cooktop in my kitchen with a little less disdain as a result of your post! F & F!
12:27 PM on 10/14/2012
"Weight loss through excercise is a flawed option." Why? Because, as you basically say, most people just can't stop eating. You hit the nail on the head there. But in actuality, weight loss through excercise is a great option, if you thought people were strong enough to make a choice and stick with it.

Most people just don't have the will-power to be disciplined enough to control their urges. It's as simple as that. You gotta call a spade a spade. And why can't they control their urges? It's also simple: they just don't want it bad enough.

Come hell or highwater, I'm gonna make it happen. If people don't have this mindset, then they will probably cave. And regardless of the "emerging science", if they refuse (and it is a choice) to adopt this mindset, AND TO STOP PUTTING FOOD IN THEIR MOUTH AT EVERY WHIM OF HUNGER then these people will always be overweight. Watch and see buddy.
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chamberwindow
Socialism or barbarism.
11:39 PM on 10/14/2012
What? I can't hear you. Your horse is so high. You might have to come down from there. I hope when you get fat some day and can't lose the weight you regret being so dense.
03:21 AM on 10/15/2012
Lol, that's your response? You can't attack my argument because my argument is solid but you don't like what I say so attempt to insult me personally? Please go back to the playground, adults are talking here.
05:46 PM on 10/15/2012
You are missing the point of the article. Certain foods (carbs) block your leptin receptor to tell your brain that you're full and to stop. Vigorous work outs do stimulate hunger as I have been experiencing this during my weight loss. Do it moderately but NOT as a method of weight loss. I eat foods that satisfy me and eliminate foods that will trigger hunger. ie: carbs. I do eat some but on the low glycemic index scale. This was a very good article; however, insulin being a "fat storage" regulator wasn't mentioned.
07:55 AM on 10/14/2012
Phytonutrient density and diversity seems more obviously important to our health.
Our bodies continue to crave the nutrients that our modern diets typically do not provide.
www.greensmoothieparty.com
This user has chosen to opt out of the Badges program
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07:06 AM on 10/14/2012
Weight loss= fewer carbs + fewer calories + much less TV.
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chamberwindow
Socialism or barbarism.
11:42 PM on 10/14/2012
Yah I'm sure that if you completely remove all of the TVs in your house, that is like forty pounds right there.
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Yogamum
Nature girl
03:49 PM on 10/15/2012
Less TV - so true. Many people say they don't have time to exercise or cook but then they can discuss the plots to 3 hours of TV from the night before.
05:23 AM on 10/16/2012
So true. What's really funny is when people say they don't have time to cook, but they somehow have time to watch three hours of cooking shows on Food Network.

I have a love/hate relationship with cooking shows. On the one hand, they make cooking seem like an interesting and rewarding activity. On the other hand, sometimes they can make cooking seem a little unapproachable - like if you don't have a lot of fancy equipment or the cooking skills of a Michelin-starred chef, you might as well not even bother. I've have my share of laughs at Rachel Ray, with her "dump and stir" recipes, but at least she makes cooking seem like something the average person can actually do.
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cable1977
Against logic there is no armor like ignorance
03:49 PM on 10/17/2012
"Less TV - so true."

I disagree. I would say less sedentary TV watching. I run on my elliptical machine 3-4 times a week and watch TV while doing it. I hate running outside, but I love watching Star Trek, Game of Thrones, and Buff while I work out.