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David Katz, M.D.

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Passing Judgment on Genetically Modified Foods

Posted: 07/29/11 05:29 PM ET

I appreciate that the term "genetically modified"-- as in genetically modified organisms (GMO) or genetically modified food (GMF) -- conjures images of Frankenstein's monster (or at least, Frankenstein's monster's lunch), and makes people freak out. I know it makes people freak out, because I hear from them about it routinely -- some to ask my opinion, others to offer theirs.

Let's put the issue on trial before we reach a verdict. In a variation on the theme of evidentiary justice, I offer the defense perspective first and then the prosecution.

For the Defense:

I have two dogs, Bramble and Zouzou. I love them, they love me. They are definitely on my short list of BFFs. And they are, undeniably ... genetically modified. Every dog that isn't a wolf is genetically modified through a process better known as breeding. Breeding -- or more specifically, selective breeding -- is the controlled mating of individual members of a species to get the right combination of genes into their offspring. While the process may not involve test tubes, its effects are as dramatic and profound as anything a laboratory could cook up. Genetic modification through the process of selective breeding has turned wolves into Chow Chows, and Chihuahuas.

If you have cats that aren't ocelots, they, too, are the product of willful, genetic modification. As are our horses, goats, chicken, sheep and cattle. And that list gets us into the realm of food. The domestic chicken and cattle many of us eat are the product of many generations of selective breeding, i.e., genetic modification.

Nor is this characteristic limited to animals. Virtually every plant food we eat is a product of selective breeding, and often, more active manipulation of genes as well. In fact, Mendel -- the father of modern genetics -- revealed to us all the existence of genes by ... modifying them. Mendel famously cross-bred pea plants to show how their traits were passed along to the next generation. So in the 1850s, we had, in essence, genetically-modified peas.

Tomatoes, Romaine lettuce, pineapple, corn, watermelon and almost all other modern produce have their origins in nature, of course, but as eaten today are decidedly products of careful, selective breeding. This can at times simply involve selecting the plants with favored traits, but may involve hybridization as well -- the fusion of parts of one plant with another in order to get offspring with the desired traits of both. We owe many of our fruits and vegetables, along with our most beautiful flowers (e.g., "hybrid" roses), to such methods.

Seedless grapes are a product of willful genetic modification. Nectarines are the result of careful culling of a recessive gene in peaches that eliminates their eponymous fuzzy skin. Ever try a tangelo? It is the hybrid offspring of a tangerine and grapefruit. Genetic modification, to be sure.

Then there is the ultimate defense of genetic modification. In a word: sex.

Sex between humans is so veiled in mystique, intrigue and commercials for cologne -- it's easy to forget that it is an odd, unnecessary biological process. There are creatures -- yeast among the better known, but there are innumerable other examples -- that reproduce asexually. They just ... divide, with one parent cell becoming two offspring.

While most of us tend to take sex for granted (I mean, we take for granted the fact that there IS sex), scientists studying evolutionary biology do not. They have wrestled with the question: why does sexual reproduction exist at all? After all, it involves a great deal of trouble -- the obvious elements of which include finding, wooing and often competing for a mate. Asexual reproduction is a whole lot easier.

The conclusion reached by experts is that the principal reason sex exists at all is genetic modification! Sex mixes the genes of one parent with the genes of another to produce a genetically modified product we might be inclined to call ... a child. Or pup. Or cub. Or piglet.

Why is sex, and the resultant genetic modification, advantageous? While DNA is very, very good at reproducing itself, it isn't quite perfect. Mutations happen. With asexual reproduction, those mutations simply add up over time. Eventually, they reach a concentration in the gene pool of those offspring where they threaten their survival, either by making them dysfunctional, or by rendering them very vulnerable to some environmental challenge.

In contrast, sexual reproduction dilutes the effects of such mutations every generation. Whatever mutations have accumulated in the father's genetic pond are mixed with different mutation's in the mother's, and each dilutes to half the concentration and influence of the other. Only when the same "bad" gene is present in both ponds does this fail. A well known example is sickle cell anemia, resulting when the same recessive gene is received from both parents.

So, genetic modification is rampant in our lives -- from the kitchen, to the kennel, to the bedroom. Of course, modern genetic modification takes things a step further, by introducing genes from one species directly into the genome of another by use of laboratory methods. The Defense might contend that this is merely a variation on the theme of genetic modification going on since wolves were first bred into dogs, wild fowl into chickens and spindly native versions bred into beefsteak tomatoes, or huge, seedless watermelon. But let's hear from the prosecution.

For the Prosecution:

Modern methods of genetic modification differ not just in degree, but in kind, from the time-honored approaches of selective breeding. Part of what defines a species is that its members can mate and produce offspring only with one another. The willful introduction of genes from bacteria or amphibians (a gene for an anti-freeze like compound enables fish and frogs to survive through bitter winter, and could be used in crops to make them resistant to a sudden frost), into produce is not business as usual. It has the potential to introduce new proteins -- and new combinations of proteins -- into the food supply. The potential consequences of this are likely to include, but not limited to: food allergies, food sensitivities and intolerance, and auto-immune diseases.

But concerns go well beyond this list. Genes introduced into crops may result in compounds that are directly toxic to humans, producing consequences from infertility, to cancer -- to who knows what else.
And that's the point. We are playing with fire when we take the genetic makeup of foods directly into our own hands. We have the scientific acumen, but not the wisdom, to "play God" in this manner. High rates of fatigue, attention deficit disorder, gluten intolerance, chronic pain, irritable bowel syndrome and affective disorders may all relate in part to our manipulation of the food supply. These are chances we should not be taking.

Can we reach a verdict?

Honestly, I don't think so.

I gave the Defense more ink not because it's the more important case, but because it's the less obvious one. Concerns about genetic modification prevail -- so the Prosecution argument tends to be the better known.

Both arguments are valid. Modern methods of genetic modification are encumbered by the law of unintended consequences. Those opposed to genetically modified foods may derive strong support from the precautionary principle, which puts the burden of proof on the defense. Until we know that genetic modification is safe, we should presume it to be dangerous.

But we can't let it go at that, because by one means or another, almost our entire food supply is already the product of genetic modification. We are now a global population of 7 billion and rising, and in the absence of genetically modified crops, we would already be unable to feed ourselves. In some cases, of course, we already fail to do so. (As an aside, I encourage all those adamantly opposed to genetically modified foods to be as adamantly supportive of family planning and birth control.)

Genetic modification has the potential to help more people eat the recommended servings of vegetables and fruits by making crops resistant to frost, and produce resistance to spoilage -- thereby lowering costs and increasing availability. Genes that make crops pest-resistant could mean less use of pesticides, with benefits for human health and the environment alike.

So, we are likely left with a hung jury, because a summary judgment about genetic modification means reaching the same verdict about baby and bathwater. We really need to distinguish between them. Genetically modified foods can be -- and almost certainly already are in some cases -- overtly harmful. Abandoning genetic modification of foods, however, is impractical, and with a broad definition applied, impossible. It, too, could result in harm -- and missed opportunities.

Genetic modification is the means -- some versions are new and others are as ancient as sex itself. It is the ends we must judge, on a case-by-case basis.

-fin

Dr. David L. Katz; www.davidkatzmd.com
www.turnthetidefoundation.org

 

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I appreciate that the term "genetically modified"-- as in genetically modified organisms (GMO) or genetically modified food (GMF) -- conjures images of Frankenstein's monster (or at least, Frankenstei...
I appreciate that the term "genetically modified"-- as in genetically modified organisms (GMO) or genetically modified food (GMF) -- conjures images of Frankenstein's monster (or at least, Frankenstei...
 
 
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02:58 PM on 08/05/2011
The dirty little secret in genetic engineering is that most of the traits that help a given GMO crop grow better under particular conditions were actually produced using conventional breeding techniques. The biotech companies raid germplasm all over the world for the best seed stock. Only then do they insert the traits for Roundup Resistance or BT, thereby enabling them to claim patent rights.

Genetic engineering, for the money invested, has given us very very little in the way of sustainable food production. Instead it has given us superweeds that break farm equipment, superbugs resistant to all but the most toxic pesticides, genetic pollution and loss of biodiversity, impoverished farmers that can't continue to afford the ever-increasing price of GMO seeds and chemicals, sudden crop death, new soil diseases, water pollution, and a huge increase in pesticide and herbicide usage worldwide.

We already have the technologies to grow enough food for everyone. It's called Agroecology, and even the United Nations believes it has far, far greater potential to end hunger than genetic engineering.
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01:15 PM on 08/02/2011
hello dr. katz: are you diggin' this lively debate? any thoughts?
07:10 AM on 08/02/2011
Good article although as someone who is fairly knowledgeable and concerned about GMO's I did note some errors in your conclusions. My concerns though are why do we not have a choice, why aren't these foods labeled. They put things in our food without our knowledge and without ANY TESTING . The same way the cigarette companies hid evidence and fought labeling we have the same greedy coverup, I hope we never have the same consequences.
mothergrace
If they knock you down, bite 'em on the ankle.
06:27 PM on 08/01/2011
False equivalency.

All types of breeding mentioned are not the same as GMO and no amount of semantics will make it so.

There is no way many of these organisms could occur even with the most dedicated breeder. You may have a dog that is the result of breeding two different types of dog together but you are NEVER going to get a "dog" that is the result of breeding one with a cat. GMO can do that, natural breeding cannot.
10:29 PM on 08/01/2011
Actually, selective animal breeding (as was done to create today's known breeds) and hybridization of fruit and other plants *are* forms of genetic modification, hence they're GMO. What those forms of modification are not is genetic engineering.

They aren't combining a dog with a cat or anything of the sort. To do that would result in a dog-cat hybrid, not a dog. With genetic engineering, scientists can take a very minute part of an organism's DNA and splice it into that of another. We're talking a teeny-tiny fragment of genetic code.

I don't buy dogs, I adopt them from the pound. But if they could isolate the part of a shark's DNA that made them immune to cancer and splice that into the DNA of a dog, I would definitely consider it a plus if I adopted a dog that was born with that trait. Whereas I would not like having a dog- shark hybrid because it'd be all scaly and would probably have a biting problem
mothergrace
If they knock you down, bite 'em on the ankle.
11:08 PM on 08/01/2011
Despite the fact that it is argued that the genetic manipulation in a lab is the same as has been done for centuries, it is not even defined the same.

And even though there is no such thing as a cat-dog hybrid, there are salmon that have the genes of pout fish that would never occur in nature.

P.S. Not only would your dog be scaly with a biting problem, it might have an unlimited supply of teeth!
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03:20 PM on 08/01/2011
homegrown is alright with me, homegrown is the way it should be, homegrown is a good thing, plant that bell and let it ring. thank you neil young.
10:59 AM on 08/01/2011
Wake up doctor!
GM Crops Decimating Monarch Butterflies

http://eatdrinkbetter.com/2011/07/26/gm-crops-decimating-monarch-butterflies-habitats/
mothergrace
If they knock you down, bite 'em on the ankle.
06:28 PM on 08/01/2011
Probably bees too.
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09:11 AM on 08/01/2011
a book by francis moore lappe, entitled" world hunger: twelve myths" would help with this debate. she also authored, "diet for a small planet".
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sabelmouse
i love to tumble , ask me why .
11:54 AM on 08/01/2011
thanks for that ''diet and recipes for a small planet'' have been with me for decades.
12 myths is a must read. i just looked it up here
http://www.foodfirst.org/pubs/backgrdrs/1998/s98v5n3.html
you might like this guy
http://rajpatel.org/
he writes about this and his book '' stuffed and starved'' is an eye opener how the politics work and have since victorian times and even before.
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03:34 PM on 08/01/2011
thank you, sabelmouse. i will check it out. another is " the feeding web", by joan dye gussow.
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09:28 PM on 08/01/2011
thanks again, sabelmouse-later
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03:35 AM on 08/01/2011
oh no, 2:15 a.m., that's it for me. nighty-night all.
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03:16 AM on 08/01/2011
hi there, weedetr here. my thanks must go to euell gibbons, and johnny carson too, because johnny got into what euell was saying and had him on the show frequently. as a result i found a copy of "stalking the wild asparagus". he taught me how to see food at my feet as i waiked through nature, even my own backyard. soooo, i gathered the seeds and started them in my own garden, and ever since, when i gather some garlic mustard, or wood sorrel or goosefoot or purslane or dandelions, i smile and chuckle a bit and thank euell, wherever his spirit may be for what he passed on to me. i know that organic works, that building the soil organically works. healthy soil makes healthy plants makes healthy people, and i wouldn't do it any other way. no corporation, no lobbyist, no congressperson can steal any of this from me, or you if you so choose. it's every individual's choice, compost or monsanto.
01:48 AM on 08/01/2011
Genetic manipulation of crops is clearly being abused by the current companies (though its basically just Monsanto in charge). This does not necessarily mean that genetically modifying our food is wrong. We have billions of people to feed, and GMOs have potential to help us lessen our impact on the planet as we try to feed all these people. Modifying crops to require less water and produce more yield is probably necessary in the near future unless we cut down on reproduction.
The way Monsanto has abused our farmers and this technology to sell more of their chemicals is wrong, but don't discredit GMOs. If we use them responsibly, they could end up making organic foods look bad for the environment.
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omsandi
01:06 AM on 08/01/2011
You're talking apples and oranges here - selective breeding is no comparison to GENETICALLY ENGINEERED crops.

Genes playing musical chairs in the DNA sequence, turning off/on in expression, and even transferring to your gut bacteria and producing pesticide in your intestines; organ damage and allergic reactions (and who knows what else turns up long-term); these are the hallmarks of Genetically Engineered crops--not of selective breeding. They are freaks of science, not nature.

And do you really trust the biotech companies to monitor their own safety? They basically submit a report to the FDA that says 'our products are safe because we say they are' and the FDA accepts it.
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w84it
04:34 PM on 08/01/2011
Couldn't agree more. F&F
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elblanc0
Whatever good things we build end up building us.
11:58 PM on 07/31/2011
Mutations happen. That's the defense? Is there an instance in nature where a plant has mutated to include animal genes for antifreeze? Or vaccines for hepatitis? No. This is modification outside of nature and therefore, cannot be defended using the Gregor Mendel defense. We have no empirical basis by which we can just assume these laboratory changes are safe.

The old 'well, its the only way to feed our overpopulated planet' defense is nonsensical if feeding them means giving them cancer or poisoning the populations we are claiming to save.

Monsanto has modified soybeans to withstand higher and higher doses of their own ultra-toxic herbicide, Roundup (convenient, no?). The consequence of this, naturally, is that higher amounts of Roundup will be sprayed into the environment. How is that in any way a potentially a good thing? We poison ourselves to feed ourselves? Eh?
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jennielake
Intellect is Learned... Wisdom Already Knows
11:32 PM on 07/31/2011
Monsanto, and those who allowed the laws to protect them need to GO !

... NOW would be good
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jennielake
Intellect is Learned... Wisdom Already Knows
11:31 PM on 07/31/2011
Genetically Modified Food = Genetically Modified Humans

... this must STOP !
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cpbsmw
War is won by the other guy dying not you - Patton
11:33 PM on 07/31/2011
Though not in as direct way as can be done now, humans have been altering the genes of food since we first started farming.
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12:52 AM on 08/01/2011
yes, but monsanto is playing russian roulette on a mass scale.
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10:17 PM on 07/31/2011
to what extent do you think monsanto will go to acquire total dominance of what we eat, i.e. our access to true organic seeds, places to grow, and our right to sell it.