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David R. Hamilton, Ph.D.

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How Meditation Affects the Gray Matter of the Brain

Posted: 10/07/10 09:00 AM ET

I like to meditate. It makes me feel at ease and I am convinced that the sense of calm it produces helps me to handle the daily challenges of my life. There are, of course, times when I don't keep up my daily practice of sitting quietly for 10 or 15 minutes, but these are the times in my life when I experience more stress.

Stress affects everyone. I don't know a single person who doesn't get stressed. But unfortunately, it plays a major role in illness. According to the Centers for Disease Control and Prevention, in fact, up to 90 percent of doctor visits in the U.S. may be stress related. Meditation is an antidote to stress, just as an aspirin can counter a headache. A regular practice can be a major boost to health.

It calms the nervous system. It's good for the immune system. It's also good for the heart; it helps produce nitric oxide (not nitrous oxide -- that's laughing gas!) in the arteries, dilating them and reducing blood pressure. It also smooths heart rhythms.

But thanks to an explosion of brain research we now know that it also physically impacts our gray matter.

One study to show this was led by scientists at the Center for Functionally Integrative Neuroscience at Aarhus University in Denmark. Comparing MRI scans of the brains of meditators with the brains of non-meditators, they showed that meditation causes actual physical changes in the gray matter of the lower brain stem. Meditation makes the gray matter grow.

In another study, scientists Giuseppe Pagoni and Milos Cekic, from the Department of Psychiatry and Behavioral Sciences at Emory University in Atlanta, compared the volume of gray matter in the brains of people performing Zen meditations with another group who were not meditators.

The volume of our gray matter normally reduces as we get older and this is what the scientists found in the group of non-meditators. But for the meditators, their gray matter hadn't reduced at all with age. According to the scientists, meditation had a 'neuroprotective' effect on the meditators: It protected the brain from some of the effects of aging.

This mirrors some 2008 Harvard research that analyzed the genes of meditators against non-meditators. It was the first study of its kind to measure the genetic impact of meditation and found that 2,209 genes were differently activated in long-term meditation practitioners compared with non-meditators. And even looking at novice meditators, they found that 1,561 genes were affected after only eight weeks of meditation practice. They concluded that the genetic effects of meditation may have long-term physiological consequences, one of which was a slowing down of the rate of aging.

We have all heard the stories of people under extreme stress whose hair turns white in a matter of weeks. We know that stress can speed up aging. So why should it be a surprise to us that a technique to combat stress should be able to slow aging?

There are many different forms of meditation. A study at Massachusetts General Hospital examined the impact of the Buddhist 'Insight' meditation on the brain. Insight meditation is a technique of moving our attention over the body or focusing on our breathing. The study found that it caused an increase in thickness of the prefrontal cortex in the brain, the part just above the eyes and associated with attention.

Several areas of the brain are active when we meditate, but most pronounced is the prefrontal cortex because when we meditate we are focusing our attention on something -- whether that be the body, our breathing, a word, a candle or even a spiritual ideal. When this area is active, just like a muscle being exercised, it grows.

Neuroscientists use this analogy to describe the way the brain changes. When we exercise a muscle it becomes larger and denser with muscle mass. In a similar way, when we exercise any part of the brain, which we do when we meditate, it becomes larger and denser with neural mass -- gray matter. The phenomenon is known as neuroplasticity and describes how the brain actually changes throughout life.

When I attended university I learned that the brain is hardwired once we reach young adulthood. The analogy used is that when we are young, the brain is a bit like dough, which can be kneaded into various forms, but when we reach young adulthood we put the dough in the oven and it comes out with a bread crust on it. The brain is then 'hardwired,' we were taught.

But this analogy has since been abandoned. We now know that we never put the dough in the oven. Our gray matter is ever-changing as we experience life; as we learn, walk, run, dance, and when we concentrate, as we do when we meditate.

Our gray matter is changing until the last seconds of our life. It grows even with our last breath.

References:

For the study where meditation caused changes in the gray matter of the lower brain stem, see: P. Vestergaard-Poulsen, M. van Beek, J. Skewes, C. R. Bjarkam, M. Stubberup, J. Bertelsen, and A. Roepstorff, 'Long-Term Meditation is Associated with Increased Gray Matter Density in the Brain Stem', Neuroreport, 2009, 20(2), 170-174. Link to article.

For the study where Zen meditation impacted gray matter, see: G. Pagoni and M. Cekic, 'Age Effects on Gray Matter Volume and Attentional Performance in Zen Meditation', Neurobiology of Aging, 2007, 28(10), 1623-1627. Link to article.

For the study where meditation produced effects at the genetic level, see: J. A. Dusek, H. H. Otu, A. L. Wohnhueter, M. Bhasin, L. F. Zerbini, M. G., Joseph, H. Benson, and T. A. Liberman, 'Genomic Counter-Stress Changes Induced by the Relaxation Response', PLoS ONE, 2008, 3(7), e2576, 1-8. Link to article.

For the effect of the Buddhist Insight meditation on the prefrontal cortex, see: S. W. Lazar, C. A. Kerr, R. H. Wasserman, J. R. Craig, D. N. Greve, M. T. Treadway, M. McGarvey, B. T. Quinn, J. A. Dusek, H. Benson, S. L. Rauch, C. I. Moore, and B. Fischi, 'Meditation Experience is Associated with Increased Cortical Thickness', Neuroreport, 2005, 16(17), 1893-1897. Link to article.

 
 
 

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I like to meditate. It makes me feel at ease and I am convinced that the sense of calm it produces helps me to handle the daily challenges of my life. There are, of course, times when I don't keep up ...
I like to meditate. It makes me feel at ease and I am convinced that the sense of calm it produces helps me to handle the daily challenges of my life. There are, of course, times when I don't keep up ...
 
 
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Dustin Rudolph
Clinical Pharmacist & Certified Nutritionist
11:21 AM on 10/12/2010
We definitely live in a world today that constantly bombards us with all kinds of activity which can lead to information overload and stress. Stress... uggghhh!! Nobody likes stress. But in the American culture we often don't even think about taking time to relax and renourish our brain to reduce our stress. I'm guilty of this myself. And this article does a great job of pointing out the benefits that as few as 15 minutes a day of meditation can have on us. We stay young, have less stress, and get re-energized. And who wouldn't want that?!

Dustin Rudolph
www.PursueAHealthyYou.com
10:08 PM on 10/08/2010
I practiced meditation sporadically throughout my life. I only recently began meditating daily. The research on brain change and my desire to quiet my brain and become more connected to universal energy spawned my daily personal practice. What a beautiful addition to my day. I wake up and relish the thought of my morning meditation.
06:46 AM on 10/09/2010
Hi Charlotte, Great to hear you have such a good experience with meditation. Have a great day! :-)
11:26 AM on 10/08/2010
When I go into meditation I start at the prefrontal lobe, then springboard into the ocean of my conciousness. I revel in swimming around awhile. The idea that you have to try and "do" something in meditation is overstated and it just confuses people. You can have alot of mental fun in meditation, and eventually you will get to the place where your Ego is unimportant.
06:47 AM on 10/09/2010
I love your style! That's my experience too!
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Ramkshrestha
Welcome to Nepal - the birthplace of Buddha
06:01 AM on 10/08/2010
Good stuff!
06:47 AM on 10/09/2010
Thanks! :-)
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SarcasticFringehead
Mute Nostril Agony
12:49 AM on 10/08/2010
In this age of multi-tasking, cellphones, texting and every other form of distraction, I can't help but wonder if the attention spans of modern people are getting shorter and shorter.

A shrinking attention span would explain an awful lot about our culture and even our current politics.

People just don't seem to be able to pay attention long enough to see "the big picture" or to even discern what is blatant manipulation and what is factual reality.

Perhaps meditation is the antidote to this condition of Attention Deficit Disorder among such a large part of the U.S. population.
06:49 AM on 10/09/2010
I agree! A nice side-effect of meditation is an increased attention span. Actually, there's a study that found TM to be of excellent benefit to kids diagnosed with ADHD.

One of the kids in the study, if I remember correctly, reported that she found herself stopping to think before she said stuff. Great result!
11:30 PM on 10/07/2010
The prefrontal cortex is not like a muscle this is the wrong analogy and neuroscientists should stop using it. When the prefrontal cortex is under stress it contracts when it is relaxed it expands. As the prefrontal cortex expands it becomes less densely pact and this causes a change in its shape not an increase in its mass. When a person meditates their mind is focused on the object of meditation and not on the aspects of their personal life that causes them stress. As a person go’s deeper and deeper into meditation each breath becomes shorter and more shallow this has a relaxing effect on the body and the mind.
08:03 AM on 10/08/2010
The one thing I would like to add is that " The Prefrontal Cortex " acts more like a unfolding antenna then a muscle.
06:56 AM on 10/09/2010
Hi Michael, I know where you're coming from but I'm referring to research that shows an increase in number of neural connections (neuroplasticity), often at the rate of millions of new connections per minute.

This has the effect of increasing density between neurons, which pushes them apart. The area thus increases in size, but there is also a substantial structural change through neuroplasticity through the birth of millions upon millions of new neural connections.

This is where the muscle analogy comes in; the increased neural density of millions of new neural connections is akin to the increased muscle density of a person exercising. It's not a perfect analogy, which I appreciate, but I think it is a good one for teaching the , especially to people who have no knowledge of the subject.
09:27 AM on 10/09/2010
Do to increased activity in the prefrontal cortex the brain is reorganizing itself by making new neural connections in that area of the brain. The neurons (nerve cells) are adjusting their activity in response to changes made in the neural environment. As new neural connections increase the density between neurons old neural connections decrease the density between neurons do to lack of use. What this means is that the brain is reshaping itself in order to compensate for the increased activity in the prefrontal cortex.
03:16 PM on 10/07/2010
All the studies cited boil down to a simple principle science is confirming: stress is fear, peace is power. Peace is brain power. As we cultivate peace as our attitude toward life, higher order brain function expands, integrates, and lights us up with the intelligence to succeed at family and career and achieve a healthy longevity. Conversely, stress robs us of this enormous brain power. Stress hormones shrink higher brain structure while expanding the lower structure that habituates stress reactions (Dias-Ferreira, 2009).
Ninety-five million Americans suffer from stress. Stress can be transcended. That's what mindfulness is about. Stress is largely a function of anxious thoughts turning into upsetting emotions that see a threatening world, wiring our brain for “fight or flight.” This is where “neuroplasticity” offers a solution. It means a change of mind can rewire our brain. Attitude is neuroplastic. Shift your attitude from fear and stress to dynamically peaceful and the brain rewires for higher functioning. That’s why mindfulness works on the brain
“Dynamically peaceful” ignites neural networks that make us passionate about work, joyful about life, and cool, calm and collected in a crisis. This in turn stimulates executive functions that make us peak performers. Change can happen quickly – in a matter of eight weeks with a simple practice (Davidson, Kabat-Zinn, 2003). Mindfulness covers a wide range of methods from meditation to cognitive behavior to practical spirituality. http://donjosephgoewey.com
06:58 AM on 10/09/2010
Hey Don, thanks for that comment! You have a nice way of making the point, and I agree with you!
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jeanneyogini
02:56 PM on 10/07/2010
I think what's more significant is the brain research showing that meditation can change how the brain reorganizes it's neural networks, toward more coherent, integrated functioning—not just changes in grey matter (which can happen by playing music or repeated mental tasks). Specifically, 25 peer-reviewed EEG studies on Transcendental Meditation have shown increased alpha coherence in the brain's frontal areas. This is different from increased "cortical thickness," which doesn't indicate coherence, only increased brain activity in that area. See Huff Po article: http://www.huffingtonpost.com/jeanne-ball/keeping-your-prefrontal-c_b_679290.html

EEG coherence is important because everything good about the brain is dependent on it's coherent, orderly functioning. Coherence is associated with higher IQ, improved moral reasoning, faster reaction time, increased creativity and the experience of pure consciousness or inner wholeness.
07:01 AM on 10/09/2010
Hi Jeanne,

Yes, I agree. I chose only to write a short piece (about 800 words) but with more space I would have included EEG research and coherence, which is excellent and very important research. The main reason I chose the neuroplasticity research was because it's quite topical at the moment and I wanted to help bring meditation into the discussions.
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zkelly
02:22 PM on 10/07/2010
not news to those who practice meditation ;)

try it! meditation and exercise destroy stress. it just melts.
07:02 AM on 10/09/2010
Amen!! :-)
12:52 PM on 10/07/2010
Dr Hamilton doesnt say how he says that it does but how ?

how is explained by Dr john Hagelin : practice of TM contacts and enlivens the unified field
12:47 PM on 10/07/2010
in 1970s Maharishi Mahesh Yogi speaking to some scientists predicted this for Transcendental meditation (TM) it will improve functioning of the genes and it will reverse aging

i must say to the author : reporting on meditation improving brain functioning without mentioning TM [ and Fred Travis , Alarik Arenander ]is like reporting on the presidency without mentioning the president

it is largely TRANSCENDENTAL meditation which ha sall the benefits [ and the research ] claimed for meditation

no other meditation was shown to REST the thalamus while enlivening prefrontal cortex and no other meditation has shown GLOBAL EEG coherence

and no other meditation has shown EEG readings for Maharishi's Cosmic Consciousness corellated with psychological and sociological tests

yogic flyers on the invincible america assembly in Fairfield- vedic city Iowa are having experiences of god-cosciousness and unity consciousness which are unmatched in history

and studies have shown a group of yogic flyers causes peace in the collective consciousness

a group of yogic flyers greater than square root of 1% of world population will result in permanent peace

a billion dollar endowment fund si needed to establish shelter provison and maintain it

the mechanism postulated for this maahrishi effect is materialization of Einstein's unified field
07:11 AM on 10/09/2010
Hi, I am a fan of TM meditation and I wasn't purposely trying to minimise it in any way.

I wrote about the neuroplasticity research because it is topical at the moment and is something very much in mainstream science. My thought is that when people who don't meditate learn of the health benefits (and my experience has shown me that many tend to take things more seriously when it is accompanied with some neuroscience research) some might seek to practice meditation for their own reasons.

This will then take them to whichever practice resonates most with them, which for many might be TM. I hope that makes sense. :-)
12:21 PM on 10/07/2010
in 1970s Maharishi Mahesh Yogi speaking to some scientists predicted this for Transcendental meditation (TM) it will improve functioning of the genes and it will reverse aging

i must say to the author : reporting on meditation improving brain functioning without mentioning TM [ and Fred Travis , Alarik Arenander or Dr Newberg]is like reporting on the presidency without mentioning the president

it is largely TRANSCENDENTAL meditation which ha sall the benefits [ and the research ] claimed for meditation

no other meditation was shown to REST the thalamus while enlivening prefrontal cortex and no other meditation has shown GLOBAL EEG coherence

and no other meditation has shown EEG readings for Maharishi's Cosmic Consciousness corellated with psychological and sociological tests

yogic flyers on the invincible america assembly in Fairfield- vedic city Iowa are having experiences of god-cosciousness and unity consciousness which are unmatched in history

and studies have shown a group of yogic flyers causes peace in the collective consciousness

a group of yogic flyers greater than square root of 1% of world population will result in permanent peace

a billion dollar endowment fund si needed to establish shelter provison and maintain it

the mechanism postulated for this maahrishi effect is materialization of Einstein's unified field
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ProfessorDuh
09:27 AM on 10/07/2010
Beyond the health benefits, the reason to meditate is simply to return us to the hereness and nowness of conscious human existence. So much of what we worry about or stew over are pointless phantoms from the past or groundless speculations about the future.
07:11 AM on 10/09/2010
I love it for this reason!