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9 Antioxidants That Can Help Prevent Premature Skin Aging

11/07/2013 03:47 pm ET | Updated Jan 23, 2014
  • DermApproved Providing consumers with unbiased skin care expertise

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As we get older, it's normal for our skin to gradually lose its elasticity and thin out. This is part of the skin's natural aging process. However, there are a variety of factors that can cause the skin to start aging at an accelerated rate. A big part of this "premature skin aging" is a result of free radical activity in the body.

Free radicals are molecules that are produced by environmental exposures like tobacco smoke and radiation, including radiation from the sun and other sources of UV rays, including tanning beds. Free radicals are also produced when your body breaks down food.

Antioxidants are naturally occurring substances that may provide protection against the effects of damaging free radicals on the cells in your body, including your skin. Antioxidant ingredients are already promoted in a number of skin care products available both over-the-counter and by prescription, and are being actively studied in clinical trials for a variety of medicinal uses.

Nine antioxidants to look for when choosing a skincare product:

1. Vitamin E
Vitamin E (tocopherol) is an antioxidant that is present in the skin and found in various foods, such as vegetables, seeds and meat. (1) It helps the skin look younger by boosting collagen production and in turn reducing the appearance of fine lines, wrinkles and age spots. (2, 3)

Unlike other vitamins, skin derives more of its benefits from vitamin E better through topical treatments than through oral supplements. Vitamin E is available in two forms: alpha-tocopherol (alcohol-based) and alpha-tocopherol acetate. The latter does not penetrate the skin as easily, so make sure you're reading the labels closely to get maximum benefit of the vitamin E.

2. Lycopene
Lycopene, a powerful antioxidant, is a carotenoid found in red fruits and vegetables. (4) It is, in fact, responsible for their red color. In addition to being a healthy choice for your diet, it's a great choice for improving skin texture because it promotes collagen production and reduces the DNA damage that leads to wrinkles. (5) To get the most benefit from this powerful antioxidant, you can either take a daily supplement or look for skin care products that contain it in topical formulas (lycopene is easily absorbed by the skin).

3. Green Tea
Green Tea has become one of the new age food heroes -- a helpful ally in preventing everything from heart disease and cancer to skin aging and weight gain. The full range of heath benefits may take decades to define, but research on its impact on human skin is reasonably well developed. The secret ingredients are chemicals called catechins, which are antioxidants that can clear cell damage on the skin and repair wrinkles, blemishes or other impurities. (6) When applied to the skin, green tea can reduce sun damage by reducing inflammation and tackling free radicals. (7) (It doesn't block UV rays.) When choosing a tea, its helpful to know that green tea has over five times the amount of catechins as black tea. (8)

4. Coffee Berry
As an ingredient in anti-aging formulas, coffee berry prevents collagen damage, reduces wrinkles and protects the skin against damage. (9) It also has anti-inflammatory properties (10), which can lessen the appearance of fine lines and wrinkles, leading to more youthful looking skin.

5. Resveratrol
The antioxidant resveratrol is compound that is commonly found in grapes, nuts, fruits, and red wine, among others. (11) Separate studies have shown that when topically applied, resveratrol protects against UVB-mediated cutaneous damage and inhibits UVB-mediated oxidative stress. (12-14)

6. Grape Seed
Grape seed is extracted from vitis vinifera and is rich in proanthocyanidins, which belong to the flavonoid family. Proanthocyanidins are potent antioxidants with strong free radical scavenging activities. (15) Grape seed extract has been shown to be an even stronger scavenger of free radicals than vitamins C and E. (16)

7. Genistein
Genistein is an isoflavone derived from soybeans with the capacity to inhibit UV-induced oxidative DNA damage. (17) Genistein, either topically applied or orally supplemented, was shown to effectively protect human skin against UVB-induced skin photodamage.

8. Niacinamide
Niacinamide (vitamin B3) is a powerful antioxidant that has shown to exhibit anti-inflammatory and depigmenting properties. It has also shown to improve the texture and tone of the skin, as well as reduce fine lines, wrinkles and hyperpigmentation. (18)

9. Vitamin C
Vitamin C (L-ascorbic acid) is an essential nutrient that can only come from the healthy fruits and vegetables that contain it. Vitamin C is usually touted for its cold-fighting power, but it's also under study for its impact on preventing and reversing aging skin.

It works in two ways: as an antioxidant, as well as a booster of collagen formation -- both of which are important to preserving and maintaining skin's youthful appearance. (19-21) However, boosting your intake of vitamin C-rich foods does not appear to impact your skin to any measurable degree, so cosmetic companies are hard at work to study whether it can be absorbed through the skin directly via topical creams and lotions.

References:

1. Nachbar F, Korting HC. The role of vitamin E in normal and damaged skin. J Mol Med 73(1):7-17 (1995 Jan).

2. Mayer P. The effects of vitamin E on the skin. Cosmet Toiletries 108:99 (1993).

3. Chung JH, Seo JY, Lee MK, et al. Ultraviolet Modulation of Human Macrophage Metalloelastase in Human Skin In Vivo. J Invest Dermatol 119(2):507-12 (2002 Aug).

4. Britton G. Structure and properties of carotenoids in relation to function. FASEB J 9(15):1551-8 (1995 Dec).

5. Daniells, Stephen. "Lycopene Supplement Boosts Skin Carotenoid Levels." NutraIngredients.com. 28 Jan, 2010. Web http://www.nutraingredients.com/Research/Lycopene-supplement-boosts-skin-carotenoid-levels?utm_source=RSS_text_news

6. Ehrlich, Steven D. "Green Tea." University of Maryland Medical Center. Web.

7. Elmets CA, Singh D, Tubesing K, et al. Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 44(3):425-32 (2001 Mar).

8. Lu QY, Jin YS, Pantuck A, Zhang ZF, Heber D, Belldegrun A, Brooks M, Figlin R, Rao J. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. (2005.)

9. Einstein, Elizabeth. "Skin Buzz." Allure.com. Web.

10. Farris P. Idebenone, green tea, and CoffeeBerry41. ® extract: new and innovative antioxidants. Dermatol Ther 20(5):322-9 (2007 Sep-Oct).

11. Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 186(1):28-37 (2003 Jan).

12. Aziz MH, Afaq F, Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol 81(1):25-31 (2005 Jan-Feb).

13. Aziz MH, Reagan-Shaw S, Wu J, et al. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? FASEB J 19(9):1193-5 (2005 Jul).

14. Adhami VM, Afaq F, Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia 5(1):74-82 (2003 Jan-Feb)

15. Vinson JA, Dabbagh YA, Serry MM, et al. Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in-vitro oxidation model for heart disease. J Agric Food Chem 43:2800-2 (1995).

16. Bagchi D, Bagchi M, Stohs SJ, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148(2-3):187-97 (2000 Aug).

17. Wei H, Cai Q, Rahn RO. Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis 17:73-7 (1996).

18. Bissett DL, Oblong JE, Berge CA. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg 31(7 Pt 2):860-5 (2005 Jul).

19. Burke KE. Interaction of vitamins C and E as Better Cosmeceuticals. Dermatol Ther 20(5):314-21 (2007 Sep-Oct).

20. Traikovich SS. Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg 125(10):1091-8 (1999 Oct).

21. Geesin JC, Darr D, Kaufman R, et al. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 90(4):420-4 (1988 Apr).

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