More

Featuring fresh takes and real-time analysis from HuffPost's signature lineup of contributors
Dr. Jon LaPook

GET UPDATES FROM Dr. Jon LaPook
 

Avoiding Esophageal Cancer

Posted: 09/24/09 11:08 PM ET

If you're from a Western country, there's a 10-20 percent chance that you suffer from classic symptoms of acid reflux: chronic heartburn and/or acid regurgitation.

But if you don't have those classic symptoms you may still have acid bubbling up from the stomach into the esophagus, a condition called "gastro-esophageal reflux disease" (GERD). Over the past decade, research has suggested that acid reflux can cause atypical symptoms such as cough, hoarseness, sore throat, asthma, and even chronic sinusitis. GERD can also cause chest pain, especially if the acid causes the muscle in the esophagus to go into spasm.

As an internist and gastroenterologist, I've seen patients who have suffered for years with atypical symptoms of GERD get better with treatment. Although I usually prescribe acid-reducing medication, I try to avoid an approach that relies exclusively on "better living through chemistry." In fact, my goal is to treat the symptoms with life-style adjustments alone if possible. Smoking and obesity both increase acid reflux and must be addressed. I tell my patients to limit alcohol, caffeine, chocolate, peppermint, and fatty foods (I know, basically anything that gives them even an iota of pleasure in life). I also suggest keeping a food diary to try to identify culprits such as tomato-based products or certain spicy foods. If their symptoms resolve then they can try to reintroduce the things they miss the most. Elevating the head of the bed can sometimes help.

The most serious consequence of chronic acid reflux is esophageal cancer. About ten percent of patients with long-standing acid reflux develop changes in the swallowing tube that increase the risk of developing adenocarcinoma, a deadly cancer with a 5-year survival rate of less than fifteen percent. The condition is called "Barrett's esophagus. "Fortunately, only about one in 200 patients with Barrett's esophagus develops cancer each year. And over the last year a treatment called "radiofrequency ablation" has been found to be extremely effective in treating Barrett's esophagus that is starting to show signs that it may turn into cancer.

It's estimated that almost 15,000 Americans will die from esophageal cancer this year. Fifty years ago, more than 95% of esophageal cancers were "squamous cell" -- the kind caused by smoking and excess alcohol use. As smoking has declined, the incidence of squamous cell carcinoma has dropped. But for reasons that are not clear, esophageal adenocarcinoma -- the kind linked to acid reflux (and smoking) -- has dramatically increased over the past forty years and now accounts for about half the cases of esophageal cancer. From 1975 to 2001 there was a 600 percent rise in esophageal adenocarcinoma. The obesity epidemic may well be playing a role by increasing the number of adults with acid reflux.

Gastroenterologists can diagnose acid reflux by slipping a thin, flexible instrument (endoscope) through the mouth and down the esophagus. It's a lot easier than it sounds. Patients are usually given sedation and the back of the throat is sprayed with numbing medicine to avoid gagging. There's no problem breathing because the tube doesn't go into the breathing tube (the trachea). Biopsies can be taken from the last part of the esophagus to look for microscopic evidence of Barrett's and inflammation (esophagitis) caused by acid reflux.

There is currently a controversy about who should be endoscopically screened to look for evidence of Barrett's esophagus. Only a fraction of the millions of patients with chronic reflux will ever develop Barrett's. And many patients with Barrett's have no symptoms at all. In a study in Sweden, 1.6% of the population had Barrett's but only about 40% had heartburn. And only about half of esophageal adenocarcinoma is estimated to be a result of reflux.

The American College of Gastroenterology recommends against screening the entire population but says it may be appropriate in certain populations at higher risk - such as Caucasian males over 50 with longstanding heartburn. That would be me. So for this week's episode of CBS Doc Dot Com, I underwent an upper endoscopy, explained and performed expertly by Dr. Mark B. Pochapin, director of The Jay Monahan Center for Gastrointestinal Health at New York-Presbyterian Hospital/Weill Cornell Medical Center. For more information about the Jay Monahan Center, click here.

For information about GERD from the American Society for Gastrointestinal Endoscopy, click here:

To watch my upper endoscopy, click here:


Watch CBS Videos Online

 
 
 
  • Comments
  • 39
  • Pending Comments
  • 0
  • View FAQ
Comments are closed for this entry
View All
Favorites
Recency  | 
Popularity
Page: 1 2  Next ›  Last »  (2 total)
This user has chosen to opt out of the Badges program
12:44 AM on 09/27/2009
For those stoic sort out there, you do yourself no favor by just putting up with the pain of heartburn. In my case, I did and it was acid reflux into hiatal hernia and I got an ulcer and it bleed. It bleed semi-slowly. This was at a time when I thought I wanted to die. But after two days of pooping black tar, I felt so fracking bad, I got a ride to the hospital.

I choose life and now I eat better and drink far less Curveo Gold. But at the FIRST SIGN of heartburn, I treat with - usually with cheap, faster acting antacids. My cities drinking water is one of the worst offenders, unless I filter it. Then when it started to upset me stomach, I know it is time to change the filter.

And yes, I am fat. Even fatter now that that Time of Bleeding so long ago (about 20 years).

So it goes. Your mileage will vary.
10:44 PM on 09/26/2009
Scleroderma, an autoimmune disease, can also cause the symptoms associated with GERD. The body produces excess collagen which attacks tissue systems (such as the valve between stomach and esophagus) and can cause a number of other conditions (heart and lung disease) even worse.
Konnie
PO'd PROGRESSIVE
08:12 PM on 09/26/2009
another perspective here: i had a hiatal hernia, and my stomach had passed all they way thru and was basically upside down laying over the bottom of my lungs leaving me with severe shortness of breath, and the stomach acid pooling at the bottom of my esophogus. every test i took was inconclusive.
i was finally referred to a surgeon and after more tests told me i needed a nissan wrap. that's where they pull
the stomach back into place, and pull the diaphragm and top of the stomach together and wrap it
around the esophogus. one will never have another hiatal hernia, and the esphogus is reinforced. that's probably not the "medical" explanation. anyway. it took 6 months for
the little lung air sacs to refill the" protein to function properly. the acid reflux and cough are gone.
with only part of my stomach left i am losing weight.........the kicker is all the little nerves at the top
of the stomach that
create hunger pains and the sensation of hunger have been changed somehow.. i can go all day before i realize
i haven't eaten anything.....but the relief from the acid reflux was instantaneous..
03:29 AM on 09/26/2009
One thing the doctor has wrong: fat does not necessarily produce more reflux. It depends on the type of fat. Saturated fat is often associated with hard to digest protein (such as in meat) and increases the risk of reflux. But poly and monounsaturated fats (like that in nuts) does not increase reflux. This is important, since if you decrease fat in your diet, then you'll likely have to increase carbs, which almost certainly will increase reflux in most people (as many have noted here).

Also, the doctor's point about PPIs not necessarily decreasing the risk of BE/cancer is important. PPIs decrease symptoms, but not necessarily harmful reflux of bile acids, which are a likely cause of BE/cancer. Doctors get away with treating GERD with PPIs because the patient feels better, and the risk of developing BE/cancer is relatively low even with reflux. But the PPIs are as likely to promote BE/cancer (by hiding reflux) as much as prevent it. For this reason it is always better to treat GERD with lifelstyle changes that reduce reflux (smaller meals, raised head of bed, etc.).
06:09 AM on 09/26/2009
Slight correction to my post above: The research about fat and GERD dealt with whether there was an association between fat intake and risk of esophageal cancer, not reflux. So what has been found is that total fat and saturated fat are associated with higher BE/EC, but that mono and polyunsaturated fat intake (nuts, olive oil, omega-3 fish oil) is associated with LOWER rates of BE/EC. Also, the association of saturated fat with EC only applied to adenocarcinomas, not squamous-cell carcinomas. The effect on "reflux" is less well known, but presumably lower for mono and polyunsaturated fats.
photo
HUFFPOST SUPER USER
dadw5boys
Disabled Vietnam Vet
02:29 AM on 09/26/2009
One thing they ALWAYS leave out you should know. Right in front of your esophagus is the Blood Vessel that carrys the blood between the chambers of the heart.

If the ACID eats thru your esophagus it can eat a hole in that HIGH PRESSURE blood vessel. Scary huh ? Gurggle Gurrgle.

I stay erect somehow for at least 2 hours after I eat and I have never had the reflux come back.

But a Paramedic scared me strainght with this info.
HUFFPOST SUPER USER
Fred54
Maine-iac
11:12 PM on 09/25/2009
In decades past, I had problems with reflux. Then I mariried a diabetic. I've been on a low-carb diet and my reflux has virtually disappeared. I try to stay aware of what's going on. My mother died of esophogeal cancer 20 years ago. One irony was that she was someone who tried to stay on top of her medical situation. But she didn't know what was going on until about four months before she died.

The doctor told me (and this was 1989) that it was highly inoperable due to to very thin tissue. Reconstructon would have been difficult. It would migrate quickly into other organs.

I pray that treatment has advanced in the past 20 years, and that it will continue to progress.
10:49 PM on 09/25/2009
At age 34, I was diagnosed with Stage IV, inoperable squamous cell carcinoma of the esophagus. I was treated with radiation therapy only at Shands, Gainesville, Fl. I was told that there was nothing that could be done for me and I had only 2 weeks to 6 months to live. After the radiation, the oncologist gave me less than a 5% chance of surviving for 5 years. It has been 35 years since I began my treatment.. Thank you for this article, I found out about it from a friend who belongs to an on-line esophageal cancer support group of which I have been a member for the past 10 years. I served on the board of the Esophageal Cancer Awareness Assn and anytime there is something written to bring awareness to this deadly cancer, we are extremely grateful. Although esophageal cancer is gaining in the number of new cases diagnosed, it is still considered a relatively rare cancer. Because of this on-line group, I have met quite a few people who have survived a number of years, they continue to give back by posting their survival stories and helping newly diagnosed patients with first had knowledge of their treatments and problems they encountered after surgery. There are also very knowledgeable care-givers who remain active on this group to help others.
HUFFPOST SUPER USER
DrLaPook
Medical Correspondent, CBS Evening News with Scott
12:55 AM on 09/26/2009
Dear Jane,
Thank you so much for writing. How wonderful and uplifting to hear such a success story. You are right that esophageal cancer does not get enough attention. We desparately need more basic research into prevention and treatment. Amazingly, 800 million dollars are spent on treatment annually in the U.S. yet only 22M in research is being funded by the National Cancer Institute.
http://www.nci.nih.gov/aboutnci/servingpeople/esophageal-snapshot.pdf


Jon
This user has chosen to opt out of the Badges program
03:51 PM on 09/25/2009
A very timely article. My husband is 2 weeks post-op from a transhiatal esophagectomy. He is 55 years old, and in great health, but because of a lifetime of esophageal reflux with horrible cough, he had an esophagoscopy in October 07 which showed high grade dysplasias. We opted for radiofrequency ablation which was done twice, but in June of 09 his biopsies were positive for cancer. Thankfully it was picked up at an extremely early stage, and he is doing well. It is only because of frequent surveillance that the adenocarcinoma was picked up at such an early stage, when chance of long term survival is its greatest. I encourage anyone over 50 with history of reflux to insist on an esophagoscopy. I'm sure there are more people who need them, but as the article says, it is very difficult to know who needs frequent monitoring.
And while we are at it, my health insurance has covered everything, in an expeditious and efficient way -- the way everyone's health insurance should work.
I wish this cancer had higher visibility, because the rate at which new cases are being diagnosed is truly frightening.
01:47 PM on 09/25/2009
When I scheduled my routine colonoscopy, I asked my GI doc to also do an EGD because of my long history of reflux. He brushed me off at first, saying that I just needed to take a proton pump inhibitor and go on with my life. I told him I'd had reflux for over 20 years, and would he just humor me. He finally gave in and agreed. No one was more shocked than he when he discovered my Barrett's. Biopsy showed high grade dysplasia and he recommended surgery. I had an Ivor-Lewis esophagogastrectomy, and the path showed superficial invasion by an adenocarcinoma. I am now over 8 years out and doing well, but the point is I had to insist on the procedure that found my problem and probably saved my life. Not everyone will be so pushy, so it's up to the gastroenterologist to be very wary of the patient with long-standing symptoms and to err on the side of caution when considering EGD.
HUFFPOST SUPER USER
Stephen
01:37 PM on 09/25/2009
I hate to be the bearer of bad news but oral sex may well be an emerging frontier in esophageal cancer. The research in human papilloma virus, cervical cancer, and the subsequent development of a vaccine makes me believe that this unproven but highly suspicious vector of cancer may a culprit. If I were the parent of any youthful child, male or female, I would strongly consider the valuable but expensive vaccine.

So many youngsters, harangued about chastity and virginity are doing "everything but intercourse" and I believe a time bomb is ticking.

Ulcers were thought to be solely lifestyle based (stress and diet) but a stubborn doctor in Australia suspected the bacteria heliobacter pylori and after years of ridicule was proven right.
01:11 PM on 09/25/2009
Thank you for this information. My father died of esophageal cancer in 1995 at only 57 years old. He had acid reflux for many years prior and had been a moderate smoker earlier in his life. I have long wondered if Prilosec or other similar drugs had been more readily available at the time if he could have avoided this fate.
01:00 PM on 09/25/2009
When diet and lifestyle don't resolve GERD or medications help the symptoms of heartburn, some surgical procedures have been very effective.

Last year I had an incisionless transoral fundoplication at The Ohio State University and the results were fantastic. You can read about it at their website. http://cmis.osu.edu/8821.cfm.

I am sure this procedure is not right for everyone, but neither is diet, lifestyle or medication. May be worth looking into this.
11:20 AM on 09/25/2009
I doubt this will get as many hits or responses as the MacKenzie Phillips threads, but thank you very much for posting it.

As someone who has gotten his chronic acid reflux under control this year with a combination of medication and lifestyle adjustments and who has already reversed the damage caused thereby with no signs of Barrett's, let me make one suggestion.

If someone has any of the indicators of GERD (including but not limited to bad acid indigestion after every meal, taking enough Tums and other OTC meds to sink a battleship, waking up with symptoms in the middle of the night), be very PUSHY with your internist. Make him/her aware that this is more than just something a little unpleasant so s/he gets you to a gastroenterologist who can diagnose the condition, perform a baseline endoscopy and get you treated. It's more than possible for even good internists to downplay your symptoms, given the stress under which most folks live, as stress-related indigestion. You have to TELL your doctor that it's really bothering you.

Thanks again for this post, you might lengthen a life or two!
HUFFPOST SUPER USER
aznurse
12:45 PM on 09/25/2009
well, the MacKenzie Phillips articles also make me gag.
01:13 PM on 09/25/2009
Good observation. They should give Nexium to those who go there.
08:48 AM on 09/25/2009
I am on a very low carb diet for Type II diabetes and have noticed the strangest- seemingly unrelated effects. For example, I have not had indigestion, heartburn, gas etc. for over a year. You might want to look into carbohydrates as the cause of these problems.
photo
HUFFPOST SUPER USER
sisterdebmac
02:27 PM on 09/25/2009
As someone who can get hearburn from white rice, I'd say there's a lot of truth in what you just said.
02:32 PM on 09/25/2009
sugars and refined flour products ferment, just like wine, in your system, so yes, I also now eat very healthy, carbs but no refined flour or sugar and I have no more cramps or gas.
07:55 AM on 09/25/2009
I was recently treated for a chronic cough, not by a pulmonologist or ENT, but by a gastroenterologist who found that GERD was causing irritation to the larynx and making me cough constantly. The condition is called Laryngeal Pharyngeal Reflux or LPR. I had no symtoms other than the cough.

I'm being treated with effective medication and now have no cough. After reading this article, I realize that I've also been saved from getting cancer.

Thank you for increasing awarness.
HUFFPOST SUPER USER
DrLaPook
Medical Correspondent, CBS Evening News with Scott
08:43 AM on 09/25/2009
I'm so glad that you found the cause of your cough. One comment: unfortunately, it's not at all clear whether the risk of Barrett's esophagus progressing to cancer is lowered by aggressive treatment of acid reflux with medications that lower stomach acid. So it is very important that you and your doctor discuss strategies for your follow-up.