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Mark Hyman, MD

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The Not-So-Sweet Truth About High Fructose Corn Syrup

Posted: 05/16/11 06:00 AM ET

If you can't convince them, confuse them.
--Harry Truman

The current media debate about the benefits (or lack of harm) of high fructose corn syrup (HFCS) in our diet misses the obvious. The average American increased their consumption of HFCS (mostly from sugar sweetened drinks and processed food) from zero to more than 60 pounds per person per year. During that time period, obesity rates have more than tripled and diabetes incidence has increased more than seven-fold. Not perhaps the only cause, but a fact that cannot be ignored.

Doubt and confusion are the currency of deception, and they sow the seeds of complacency. These are used skillfully through massive print and television advertising campaigns by the Corn Refiners Association's attempt to dispel the "myth" that HFCS is harmful and assert through the opinion of "medical and nutrition experts" that it is no different than cane sugar. It is a "natural" product that is a healthy part of our diet when used in moderation.

Except for one problem. When used in moderation, it is a major cause of heart disease, obesity, cancer, dementia, liver failure, tooth decay and more.

The Lengths the Corn Industry Will Go To

The goal of the corn industry is to call into question any claim of harm from consuming high fructose corn syrup, and to confuse and deflect by calling their product natural "corn sugar." That's like calling tobacco in cigarettes natural herbal medicine. Watch the slick ad where a caring father walks hand in hand with his four-year-old daughter through a big question mark carved in an idyllic cornfield.

In the ad, the father tells us:

Like any parent, I have questions about the food my daughter eats -- like high fructose corn syrup. So I started looking for answers from medical and nutrition experts, and what I discovered whether it's corn sugar or cane sugar, your body can't tell the difference. Sugar is sugar. Knowing that makes me feel better about what she eats and that's one less thing to worry about.

Physicians are also targeted directly. I received a 12-page color glossy monograph from the Corn Refiners Association reviewing the "science" that HFCS was safe and no different than cane sugar. I assume the other 700,000 physicians in America received the same information, at who knows what cost.

In addition to this, I received a special "personal" letter from the Corn Refiner's Association outlining every mention of the problems with HCFS in our diet -- whether in print, blogs, books, radio or television. They warned me of the errors of my ways and put me on "notice." For what I am not sure. To think they are tracking this (and me) that closely gives me an Orwellian chill.

New websites like www.sweetsurprise.com and www.cornsugar.com help "set us straight" about HFCS with quotes from professors of nutrition and medicine and thought leaders from Harvard and other stellar institutions.

Why is the corn industry spending millions on misinformation campaigns to convince consumers and health care professionals of the safety of their product? Could it be that the food industry comprises 17 percent of our economy?

But are these twisted sweet lies or a sweet surprise, as the Corn Refiners Association websites claim?

What the Science Says about HFCS

Let's examine the science and insert some common sense into the conversation. These facts may indeed come as a sweet surprise. The ads suggest getting your nutrition advice from your doctor. Having studied this for more than a decade, and having read, interviewed or personally talked with most of the medical and nutrition experts used to bolster the claim that "corn sugar" and cane sugar are essentially the same, quite a different picture emerges and the role of HCFS in promoting obesity, disease and death across the globe becomes clear.

Last week over lunch with Dr. Bruce Ames, one of the foremost nutritional scientists in the world and Dr. Jeffrey Bland, a nutritional biochemist, a student of Linus Pauling and I reviewed the existing science, and Dr. Ames shared shocking new evidence from his research center on how HFCS can trigger body-wide inflammation and obesity.

Here are 5 reasons you should stay way from any product containing high fructose corn syrup.

1. Sugar in any form causes obesity and disease when consumed in pharmacologic doses.

Cane sugar and high fructose corn syrup are indeed both harmful when consumed in pharmacologic doses of 140 pounds per person per year. When one 20-ounce HFCS sweetened soda, sports drink or tea has 17 teaspoons of sugar (and the average teenager often consumes two drinks a day), we are conducting a largely uncontrolled experiment on the human species. Our hunter-gatherer ancestors consumed the equivalent of 20 teaspoons per year, not per day. In this sense, I would agree with the corn industry that sugar is sugar. Quantity matters. But there are some important differences.

2. HFCS and cane sugar are NOT biochemically identical or processed the same way by the body.

High fructose corn syrup is an industrial food product and far from "natural" or a naturally occurring substance. It is extracted from corn stalks through a process so secret that Archer Daniels Midland and Carghill would reportedly not allow the investigative journalist Michael Pollan to observe it for his book, "The Omnivore's Dilemma." The sugars are extracted through a chemical enzymatic process resulting in a chemically and biologically novel compound called HFCS.

Some basic biochemistry will help you understand this. Regular cane sugar (sucrose) is made of two-sugar molecules bound tightly together -- glucose and fructose in equal amounts. The enzymes in your digestive tract must break down the sucrose into glucose and fructose, which are then absorbed into the body.

HFCS also consists of glucose and fructose, not in a 50-50 ratio, but a 55-45 fructose to glucose ratio in an unbound form. Fructose is sweeter than glucose. And HFCS is cheaper than sugar because of the government farm bill corn subsidies. Products with HFCS are sweeter and cheaper than products made with cane sugar. This allowed for the average soda size to balloon from eight ounces to 20 ounces with little financial costs to manufacturers, but great human costs of increased obesity, diabetes and chronic disease.

Now back to biochemistry. Since there is there is no chemical bond between them, no digestion is required, so they are more rapidly absorbed into your blood stream. Fructose goes right to the liver and triggers lipogenesis (the production of fats like triglycerides and cholesterol). This is why it is the major cause of liver damage in this country and causes a condition called "fatty liver," which affects 70 million people. The rapidly absorbed glucose triggers big spikes in insulin -- our body's major fat storage hormone. Both of these features of HFCS lead to increased metabolic disturbances that drive increases in appetite, weight gain, diabetes, heart disease, cancer, dementia and more.

But there was one more thing I learned during lunch with Dr. Bruce Ames. Research done by his group at the Children's Hospital Oakland Research Institute found that free fructose from HFCS requires more energy to be absorbed by the gut and soaks up two phosphorous molecules from ATP (our body's energy source). This depletes the energy fuel source or ATP in our gut required to maintain the integrity of our intestinal lining. Little "tight junctions" cement each intestinal cell together preventing food and bacteria from "leaking" across the intestinal membrane and triggering an immune reaction and body wide inflammation.

High doses of free fructose have been proven to literally punch holes in the intestinal lining, allowing nasty byproducts of toxic gut bacteria and partially digested food proteins to enter your blood stream and trigger the inflammation that we know is at the root of obesity, diabetes, cancer, heart disease, dementia and accelerated aging. Naturally occurring fructose in fruit is part of a complex of nutrients and fiber that doesn't exhibit the same biological effects as the free high fructose doses found in "corn sugar.'

The takeaway: Cane sugar and the industrially produced, euphemistically named "corn sugar" are not biochemically or physiologically the same.

3. HFCS contains contaminants including mercury that are not regulated or measured by the FDA.

An FDA researcher asked corn producers to ship a barrel of high fructose corn syrup in order to test for contaminants. Her repeated requests were refused until she claimed she represented a newly created soft drink company. She was then promptly shipped a big vat of HFCS that was used as part of the study that showed that HFCS often contains toxic levels of mercury because of chlor-alkali products used in its manufacturing.(i) Poisoned sugar is certainly not "natural."

When HFCS is run through a chemical analyzer or a chromatograph, strange chemical peaks show up that are not glucose or fructose. What are they? Who knows? This certainly calls into question the purity of this processed form of super sugar. The exact nature, effects and toxicity of these funny compounds have not been fully explained, but shouldn't we be protected from the presence of untested chemical compounds in our food supply, especially when the contaminated food product comprises up to 15 to 20 percent of the average American's daily calorie intake?

4. Many independent medical and nutrition experts DO NOT support the use of HFCS in our diet, despite the assertions of the corn industry.

The corn industry's happy looking websites www.cornsugar.com and www.sweetsurprise.com bolster their position that cane sugar and corn sugar are the same by quoting experts, or should we say mis-quoting ...

Barry M. Popkin, Ph.D., Professor, Department of Nutrition, University of North Carolina at Chapel Hill has published widely on the dangers of sugar-sweetened drinks and their contribution to the obesity epidemic. In a review of HFCS in the American Journal of Clinical Nutrition,(ii) he explains the mechanism by which the free fructose may contribute to obesity. He states that:

"The digestion, absorption and metabolism of fructose differ from those of glucose. Hepatic metabolism of fructose favors de novo lipogenesis [production of fat in the liver]. In addition, unlike glucose, fructose does not stimulate insulin secretion or enhance leptin production. Because insulin and leptin act as key afferent signals in the regulation of food intake and body weight [to control appetite], this suggests that dietary fructose may contribute to increased energy intake and weight gain. Furthermore, calorically sweetened beverages may enhance caloric overconsumption."

He states that HFCS is absorbed more rapidly than regular sugar, and that it doesn't stimulate insulin or leptin production. This prevents you from triggering the body's signals for being full and may lead to overconsumption of total calories.

He concludes by saying that:

"... the increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of HFCS in calorically sweetened beverages may play a role in the epidemic of obesity."

The corn industry takes his comments out of context to support their position. "All sugar you eat is the same."

True, pharmacologic doses of any kind of sugar are harmful, but the biochemistry of different kinds of sugar and their respective effects on absorption, appetite and metabolism are different.

David S. Ludwig, M.D., Ph.D., Associate Professor of Pediatrics, Harvard Medical School, and a personal friend has published extensively on the dangers and the obesogenic properties of sugar-sweetened beverages. He was quoted as saying that "high fructose corn syrup is one of the most misunderstood products in the food industry." When I asked him why he supported the corn industry, he told me he didn't and that his comments were taken totally out of context.

Misrepresenting science is one thing, misrepresenting scientists who have been at the forefront of the fight against obesity and high fructose sugar sweetened beverages is quite another.

5. HCFS is almost always a marker of poor-quality, nutrient-poor disease creating industrial food products or "food-like substances."

The last reason to avoid products that contain HFCS is that they are a marker for poor-quality, nutritionally depleted, processed industrial food full of empty calories and artificial ingredients. If you find "high fructose corn syrup" on the label, you can be sure it is not a whole, real, fresh food full of fiber, vitamins, minerals, phytonutrients and antioxidants. Stay away if you want to stay healthy. We still must reduce our overall consumption of sugar, but with this one simple dietary change you can radically reduce your health risks and improve your health.

While debate may rage about the biochemistry and physiology of cane sugar vs. corn sugar, this is, in fact, beside the point (despite the finer points of my scientific analysis above). The conversation has been diverted to a simple assertion that cane sugar and corn sugar are not different.

The real issues are only two.

1. We are consuming HFCS and sugar in pharmacologic quantities never before experienced in human history -- 140 pounds a year vs. 20 teaspoons a year 10,000 years ago.

2. High fructose corn syrup is almost always found in very poor quality foods that are nutritionally vacuous and filled with all sorts of other disease-promoting compounds, fats, salt, chemicals and even mercury.

These critical ideas should be the heart of the national conversation, not the meaningless confusing ads and statements by the corn industry in the media and online that attempt to assure the public that the biochemistry of real sugar and industrially produced sugar from corn are the same.

For more information on the effects of high fructose corn syrup see www.drhyman.com.

Know I'd like to hear from you ...

Do you think there is an association between the introduction of HFCS in our diet and the obesity epidemic?

What reason do you think the Corn Refiners Association has for running such ads and publishing websites like those listed in this article?

What do you think of the science presented here and the general effects of HFCS on the American diet?

Please leave your thoughts by adding a comment below.

To your good health,

Mark Hyman, MD

References

(i) Dufault, R., LeBlanc, B., Schnoll, R. et al. 2009. Mercury from chlor-alkali plants: Measured concentrations in food product sugar. Environ Health. 26(8):2.

(ii) Bray, G.A., Nielsen, S.J., and B.M. Popkin. 2004. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 79(4):537-43. Review.

Mark Hyman, M.D. is a practicing physician, founder of The UltraWellness Center, a four-time 'New York Times" bestselling author and an international leader in the field of Functional Medicine. You can follow him on Twitter, connect with him on LinkedIn, watch his videos on YouTube, become a fan on Facebook and subscribe to his newsletter.

 
 
 

Follow Mark Hyman, MD on Twitter: www.twitter.com/markhymanmd

If you can't convince them, confuse them. --Harry Truman The current media debate about the benefits (or lack of harm) of high fructose corn syrup (HFCS) in our diet misses the obvious. The averag...
If you can't convince them, confuse them. --Harry Truman The current media debate about the benefits (or lack of harm) of high fructose corn syrup (HFCS) in our diet misses the obvious. The averag...
 
 
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03:52 PM on 06/28/2011
At the end of last winter I bought a new scale and to my horror found out that I weighed 250(I am a 50 year old male). My old scale said I weighed 200, which was grossly inaccurate. So in March I began to diet, and one of the things I have eliminated completely from my diet is HFCS. I was amazed that it was in more than 75% of the foods I ate daily, particularly ketchup and breakfast cereal. Since March I have eaten absolutely NO HFCS and I have lost 40 LBs. I have always been active despite the weight. I also have completely given up fast food and most processed foods, in particular breakfast cereals. I eat mainly fresh fruits and veggies and make my own salad dressings. I do eat meat but not beef. I feel great. I think it will take a class action lawsuit against the HFCS people to get them to be a bit more honest, and am looking forward to that day.
12:33 PM on 06/20/2011
Probably the scariest aspect is the position that wikipedia.org has seems to echo the propaganda of the Corn Industry. I would surmise that they are threatened with Lawsuits if they paint too harsh a picture for HFCS, and that the links in of stories about it being "similar" to Honey, while not central to the debate about HFCS, certainly "sweeten" the picture.

What it will take is some "Hot McDonald's Coffee" Lawsuit (that I am *not* particularly fond of) claiming that they researched wikipedia.org about HFCS, and finding nothing wrong there, went on to allow it in their diet in massive quanties, being informed later, when it was too late, that it caused their liver damage, their obesity, their diabetes, etc. One Lawsuit like that, especially if the science that is not "junk science" (pushed by an industry with a vested interest in the perception being favorable more than the perception being honest) states even mild reservations that are of the Level that would normally cause someone like the FDA to pull a precription medicine from the shelves.

I think this is clearly a case of "Money Talks" and we can see the money being spent to make this talk (vested interest, not pure unbiased -- think Propoganda and you understand) seem to favor HFCS as being "good enough" for us not to worry about it too much. Remember that the best Propoganda has some truth in it that is easy to find & lies that are hard to find.
12:36 PM on 06/16/2011
The real reason people are obese? They eat out most nights and watch TV immediately afterward. Most people work long hours and sit at a desk, emailing. Once upon a time people had to walk from office to office to discuss something. Eating at McDonald's was a rare treat, not a quick way to down food while running off to take the kids to soccer practice. Ask your friends how often they take walks or ride their bikes. I guarantee the slimmer ones are on the move more often than the heavier ones. This is not rocket science. It's laziness, pure and simple. Blame HFCS all you want, but even if you were to take it out of our diets, people would continue to be plump.
02:44 PM on 06/15/2011
We recognize that moderation of sugar consumption is important. However, there are numerous factual and scientific errors contained in Dr. Hyman’s article. If facts are important to you, please see our response to “5 Reasons High Fructose Corn Syrup Will Kill You” at http://blog.sweetsurprise.com/2011/06/08/5-reasonshighfructosecornsyrupwillkillyou

Therese, Corn Refiners
HUFFPOST SUPER USER
AntiClast
If it ain't broke, don't break it!
06:14 PM on 06/15/2011
Just like Dr. Hyman said in his article above! The corn syrup industry tracks him. LOL

However, I've been looking at research articles, both pro and con on whether HFCS is worse for you, and I think Hyman nails it.

I notice gross obesity beginning about the time HFCS (which I didn't hear of until recently) was invented. I was puzzled by the rise in 350 pounders, especially after I went to Holland and saw the Dutch eating desserts for lunch but no grossly fat people. Since then more and more grossly obese people are in this country.

Bottom line: don't eat sugar at all. It is not metabolized well by your body. Worst metabolized is HFCS, according to the preliminary studies.
11:13 AM on 06/15/2011
One by-product of the manufacture of corn syrup is coal ash. ADM in Cedar Rapids Iowa has it's own electric generating plant. It burns coal. I believe the coal ash is dumped in an unregulated landfill. They have an estimated 178 thousand tons of coal ash in the pit. This former quarry is just down the road from a cereal plant.
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polishlogician
No sugar tonight in my tea..
12:19 AM on 06/15/2011
Fructose is fructose is fructose, doesn't matter if you use cane sugar, fruit juice or HFCS...the interesting part of the article was the one glossed over:

..."an FDA researcher" found "mercury"...

...now your thesis that HFCS is unlike cane sugar would be better served if you reported what exactly was is in HFCS, how that differs from cane sugar and how the production of HFCS matters...
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Parkite
Still haven't found what I'm looking for
03:20 PM on 06/17/2011
Go back and read section 2 of the article. It tells you why/how HFCS is processed in the body differently from regular table/cane sugar.
03:51 AM on 06/05/2011
With all the respect to what science says .. It is always depending on who stands behind the various studies and who financing them because there's always some economic agenda. Sugar is poison to the human body and therefore we should limit our consumption.
http://www.lifestyle-after50.com/sugar.html
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Parkite
Still haven't found what I'm looking for
03:22 PM on 06/17/2011
I believe that this article states that all sugar is problematic especially in the amounts now consumed. But HFCS contributes to fatty liver.
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HUFFPOST SUPER USER
libwingoflibwing
Leftist, Christian, Non-Violent Revolutionary
08:29 PM on 06/03/2011
HFCS is a killer. I'd like to add to the point about it being used to cover up the poor quality of processed foods.

There are four "foods" that are just not that good for us in large quantitites: HFCS, Partially Hydrogenated Soybean Oil (PHSO), white flour and salt. PHSO is the kind of fat that is dangerous for us to eat, but it is cheap and tastes good. White flour actually converts to blood glucose faster than table sugar! We all know that a high sodium diet is bad for our blood pressure and heart.

These four "foods" plus lots of preservatives, dangerous food dyes and other additives make up most of our junk food. If you add another food that is bad for those struggling with diabetes: potatoes, we have almost all of our junk food.

A trick when food is too salty is to add sugar and when it's too sugary to add salt. Both of these add flavor. So if you take something that tastes like cardboard and adds hordes of both you get flavor and it won't taste really sweet or salty, but it is.

The big disgusting thing is that white flour, HFCS and PHSO are all subsidized by the government. This is a political problem, not just a cultural one.
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VeggieLove
apparently, my micro-bio is empty
10:17 AM on 06/03/2011
I never, ever eat anything containing HFCS and no amount of advertising or new labels from the corn industry will change my mind.
04:21 PM on 06/02/2011
Very good information. Reminds me that individuals need to arm themselves with up to date information about this issue and loads of other health concerns. Ask questions of your doctors and other providers, and do your research. I found this helpful when forming questions: http://tinyurl.com/4odprtz
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sector1463
08:56 PM on 05/31/2011
I have read similar articles for many years. I think Dr. Adkins also wrote about this in his diet book. The reasons for the misleading ads and websites are money. They get money from the government and from sales. Lots and lots of money. Yes the obesity epidemic in our country is connected to HFCS. You can't get away from it. It is in everything. It is lowers the costs of candy and sodas. The more the average person can buy goes up with the use of HFCS. The science presented here is familiar and well presented. Thank you for your article.
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Ukie3
All your base are belong to us!
08:18 PM on 05/31/2011
Very powerful article, thank you!
03:51 PM on 05/23/2011
This was interesting, but there were so many typos that it made my head hurt. I guess a copy editor is not in the budget.
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HUFFPOST SUPER USER
Endogenous Light Nexus
There actually is light within you
03:47 PM on 05/23/2011
Excellent article Dr. Hyman. I'd like to hear next what you have to say about MSG.

And then the hidden epidemic of Mad Cow Disease spreading to humans and being called vCJD.

Seen http://madcowomahasteaks.blogspot.com?
02:06 PM on 05/23/2011
Thanks for posting this. There's been a lot of press warning about the dangers of HFCS, but not much that clarifies why it's worse than any other type of sugar. (Nothing that explains why, for example, a yogurt containing 90 calories and HFCS is worse for me than a yogurt containing 120 calories and regular sugar.) Your article provides some insight into that.