Arianna joined Dr. Judith Rodin, the president of the Rockefeller Foundation, to discuss unlocking "$100 trillion of opportunities in for-profit markets," on CNBC's "Squawk Box."
Dr. Rodin described a growing number of businesses eager to profit both financially and make a positive social impact with their enterprise.
"There's hundreds of trillions of dollars of private capital... and what we are saying that there are starting to be a group of investors that are looking for a 'Double Bottom Line.' They want to have financial impact, but they also want to have a social or environmental impact as well."
She added: "There's nothing wrong with making money doing good. Companies are really starting to feel that there are huge profit potentials in products that have a social or environmental good." She cited the example of GE with Echo Imagination as a significant business that has positive environmental impacts.
Asked whether a company that simply provided a good service and created jobs, but lacked a social component was of value to society, Arianna responded: "There are a lot of people and a lot of companies that want to do both and social impact investing is a way to combine these," and agreed with the host's statement that "giving someone a job is as virtuous as charity."
Arianna also flagged up the Rockefeller Foundation's $1 million prize for innovative entrepreneurship, a program which is being run in association with The Huffington Post.
Watch the entire clip below.