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Jacob M. Appel

Jacob M. Appel

Posted: December 21, 2009 01:39 AM

Beyond Fluoride: Pharmaceuticals, Drinking Water and the Public Health

What's Your Reaction:

This week's New York Times Magazine draws attention to an article in The British Journal of Psychiatry that has been the talk of bioethical circles since May, when researchers at Japan's Oita University reported that communities with increased levels of lithium in their drinking water suffered a significantly lower incidence of suicide. The Japanese data confirmed a previous study of drinking water in Texas that found a decreased incidence of both suicide and violent crime in counties with higher-than-average amounts of naturally-occurring lithium in the water. If these protective benefits are replicated -- and no equally deleterious health effects of such low-dose exposures are discovered -- public health authorities may soon confront the question of whether it is ethical to supplement all public water supplies with lithium.

The pioneering American psychiatrist Peter Kramer, best known for his work Listening to Prozac, first raised such a possibility at a conference in Germany earlier this year. Whether such a policy is justifiable will depend upon further study of risks and benefits. What is clear is that our society may soon stand on the brink of a public health revolution in which pharmaceuticals will be added directly to the water supply in order to further the common good.

The most well-known effort to fortify public water began in Grand Rapids, Michigan, on January 25, 1945, when H.Trendley Dean -- one of our nation's great unsuing heroes -- launched an effort to add fluoride to the drinking supply. Six decades later, Surgeon General Richard Carmona was able to write that "every $1 invested in fluoridation saves $38 or more in treatment costs" and that "fluoridation is the single most effective public health measure to prevent tooth decay and improve oral health over a lifetime, for both children and adults." The United States Centers for Disease Control and Prevention has declared the fluoridation of drinking water to be "one of ten great public health achievements of the twentieth century." That is not to say that fluoridation didn't have its opponents -- both mainstream dental scientists and an army of right-wing crackpots who viewed water fortification (and childhood vaccination) as part of a Marxist conspiracy. However, decades of evidence have proven them wrong. Our national dental hygiene is vastly improved from the pre-fluoride era, our water is no more expensive, and Soviet-style communism has not snatched away our liberty.

The benefits of lithium fortification may someday prove just as dramatic. Since the doses of lithium shown to be protective in both studies are magnitudes below the therapeutic levels used to control mood swings in bipolar disorder, the Japanese researchers suggest that lithium may prevent suicide through a different mechanism, possibly increasing the production neurotrophic factors that enhance connectivity among brain cells. At such low amounts, lithium is unlikely to produce the negative side effects -- hypothyroidism, nephrotoxicity, weight gain -- that complicate its use as a psychiatric drug. We should certainly make sure that these risks are minimal before tampering with the public water. At the same time, if low-dose lithium proves as good as its promise, we should not allow abstract arguments about our "freedom" to drink unadulterated water to prevent us from undertaking a mass fortification effort. If we are willing to ingest fluoride to prevent tooth decay, surely we can tolerate a trace of lithium to prevent suicides.

Lithium may actually be the tip of the fortification iceberg. The cholesterol-lowering agents known as statins might also be good candidates for inclusion in the water supply, particularly if data confirms that they increase life-expectancy in otherwise health individuals and if those susceptible to rare side-effects -- such as muscle breakdown -- could be identified in advance. The social and economic costs of supplying free bottled water to pregnant women, young children and potential side-effect victims might prove vastly lower than those of persuading all other adults to take a daily statin pill. Similarly, fortifying water with thiamine might prevent dementia in alcoholics.

Other possible agents are still in development. If researchers could effectively isolate a chemical that safely blocks pleasure pathways involved in the use of toxic substances, such as tobacco and cocaine, those blocking agents might also be added to the water supply. Preventing nicotine highs through such a novel distribution mechanism would save millions of lives annually. Each of these proposals, of course, should be evaluated on its own merits. Our society might decide that preventing suicide or cocaine addiction is worth such a mass medication effort, but lowering the cardiovascular disease associated with high cholesterol is not. What matters is that our society approaches these questions rationally and democratically, adopting the policy positions that will reduce human suffering and save the most lives possible. Knee-jerk appeals to irrational passions should have no place in this debate.

Some nay-sayers will inevitably argue that medically fortifying the public water is a violation of individual liberty. Of course, nobody is forcing those dissident individuals to drink tap water. They are welcome to purchase bottled water, as do a few hold-outs who still fear the pernicious effects of fluoride, or to dig their own wells. (These critics could learn a lesson from existing traditionalists: The Amish, for example, do not question the majority's right to use electricity, even though they prefer to light candles.) The difference between adding lithium to water and iodizing salt is a matter of degree, not of kind. From a libertarian perspective, the public ought to be informed which pharmaceuticals have been added to the water and should choose what to imbibe accordingly.

Unfortunately, some opponents will likely attempt to hold the public water hostage, arguing that because drug-free water is natural, is it somehow better. However, if the vast majority of people gain health benefits from fortifying the public water, and particularly if these benefits are life-saving, then there is nothing unreasonable about placing the burden not to drink upon the resistant minority. One person's right to drink lithium-free water is no greater than another's right to drink lithium-enhanced water. As long as the negative consequences or inconveniences are relatively minor, water fortification seems to be one of those cases where the majority's preference and interest should prevail.

Time will reveal whether lithium is indeed the next fluoride. Far more important is the revolutionary prospect of harnessing the common water supply to deliver life-saving and health-enhancing therapies to the public at low cost. The water belongs to the public, after all, and should be used for the collective good. As someone who treasures my freedom immensely -- including, I should emphasize, my inalienable right to commit suicide -- I look forward to the day when I can sacrifice whatever specious "liberty" claim I might have in consuming "natural" tap water in order to help save the lives of my neighbors and fellow human beings.

 
 
 
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HUFFPOST PUNDIT
inthelandoftheblind
Obama wants a strong Middle Class
04:13 PM on 01/05/2010
I have a fear of Santa Clause - coming into my room at night - ever since I was a child. What do you suggest we all drink in our water, for that, so I won't have such a traumatic episode ever again?

Logically speaking....If we all drink it, we will save $$$billions - and future generations - well, they can just thank me now...You're welcome ...little future people :-) !!!

And...plus....also think of all the lives of all the workers on the North Pole, which who what-if ....otherwise would never be happy?! By helping me with my delusions - they too will be so happy!!! - and can be convinced they are toiling on a tropical island! And... so...really - so...the economy is saved, and everyone will thank me.

This was a very good day..I did a very good thing today!!! :-)
HUFFPOST SUPER USER
Philip123
08:38 PM on 12/28/2009
Fluoride is detrimental to your health as has been extensively documented in the 2006 National Academy of Sciences report on the subject as well as scores of peer-reviewed studies. Without going into detail, I would just say for those interested there is a series of write-ups on the topic that can be found here http://healthjournalclub.blogspot.com/
11:20 PM on 12/23/2009
There is a vast difference between fortifying all public water supplies with minerals that frequently occur naturally in water, such as fluoride and lithium, and adding drugs such as statins. Statins, for example, interfere with the production of co-enzyme Q, a deficiency of which can cause such symptoms as muscle pain in many people (and not only those who show liver enzyme problems on blood tests). I am one of them and will never take another statin drug. If statins were in the water I would of course buy bottled water, but it was a lengthy process to theorize, test and confirm the association between my muscle pain and the offending drug. What percentage of similarly suffering people would be successful in discovering the connection between their pain and their drinking water for themselves?

And if we wish to add something to the water supply to reduce the risk of cardiovascular disease, how about magnesium? It's found naturally in many water supplies -- and I believe studies have also found lower rates of heart disease in people who drink that water.
02:28 PM on 12/23/2009
I thought there already was a lot of drugs in our water, since the water purification system can't separate them from the sewer water. I'm not sure we want to add more drugs if we can't control the dose even if we knew the effect. But hey, did anyone else hear the murder rate is as a low today as the in the 1960's? Must be the drugs in the water, right?
07:57 PM on 12/22/2009
Yes the pros and cons still need to be weighed carefully. Going back to the original research in Japan It is important to note that this study was done on naturally existing levels of lithium in the water supply in the Oita area of Japan. Some bloggers on other websites have misunderstood this as being some indication lithium is being added to the water supply in Japan, an assertion which is groundless in fact.

While the BBC report is well written there is a good report on this from the Telegraph published on 30th April and here it is in full:

http://www.telegraph.co.uk/health/healthnews/5251365/Natural-levels-of-lithium-in-drinking-water-help-reduce-suicides.html

For the orginal article in the British Journal of Psychiatry see: http://bjp.rcpsych.org/cgi/content/abstract/194/5/464

I would also like to suggest that as many Japanese people have very high reading skills in English that any articles dealing with mental health issues in Japan could usefully provide contact details for hotlines and support services for people who are depressed and feeling suicidal.

Inochi no Denwa (Lifeline Telephone Service):
Japan: 0120-738-556
Tokyo: 3264 4343

AMDA International Medical Information Center:
http://amda-imic.com/

Andrew Grimes, JSCCP, JCP
Tokyo Counseling Services:
http://tokyocounseling.com

http://tokyocounseling.com/english/
http://tokyocounseling.com/jp/

http://www.counselingjapan.com
07:31 PM on 12/22/2009
I'm so glad Jason Appel knows what's best for me. And for everyone else.
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horhay
Res ipsa loquitur
10:03 PM on 12/22/2009
Sounds like the personification of Big Brother...
12:51 PM on 12/22/2009
You make the assumption with this article, not necessarily correct, that governments want to reduce suicide.
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HUFFPOST SUPER USER
lgillooly
12:18 PM on 12/22/2009
I love the ideas, but as we all know the talk radio, special interest crowd will go beserk!!
HUFFPOST SUPER USER
BannedNBoston
Is hemp legal yet?
11:48 AM on 12/22/2009
Fluoride is a heavy metal not a healthy mineral.
Its is absorbed in large quantities by your skin when you shower.

We have added iron to food (ENRICHED) the bad form of iron is poisoning people.

The government would add toxic lithium to the water.
People would get too much from hot tub baths.
QuietLightTraveler
Scientist, Teacher, Naturalist, Photographer
10:58 AM on 12/22/2009
Soma, Soma !
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HUFFPOST PUNDIT
jsgaetano
Legum servi sumus ut liberi esse possimus
10:55 AM on 12/22/2009
Now that the EPA is promoting the use of coal ash as fertilizer, it opens all kinds of exciting doors in the field of pseudoscience!

Why should we allow chemists to rule the field of chemistry? Conservative ideology is about tearing down the tyrrany of science- we need more conservative pundits and activists telling us what kinds of chemicals the industry wants us to know is safe for us to consume.

Heck, why not just allow us to sell mercury and arsenic as health suppliments? There's a market for it, so we should be letting the Free Market decide!
QuietLightTraveler
Scientist, Teacher, Naturalist, Photographer
10:52 AM on 12/22/2009
It would take decades of exposure to lithium drinking water to really determine if it is safe. I would suggest that humankind focus its efforts on cleaning and caring for the environment rather than concerning themselves with doctoring the water. We have genetically altered crops and now you want to play around with the water. Did it ever occur to you that some people just want to live a simple, natural life.
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10:46 AM on 12/22/2009
I really hope this is a joke.
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HUFFPOST SUPER USER
zombie fairy
09:18 AM on 12/22/2009
I can't tell if you're serious or if this is a satire in the spirit of Jonathan Swift's "A Modest Proposal". Flouride is one thing (and not one I'm particularly thrilled about), but adding psychotropic drugs to the water is something else entirely. I don't mean to sound like a conspiracy theorist, but this comes entirely too close to pacifying the masses and mind control.
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HUFFPOST SUPER USER
KenMoore
Cunning Linguist
11:04 AM on 12/22/2009
" Ah yes, I love children. But only when cooked properly." WC Fields
07:55 AM on 12/22/2009
There is a significant difference in preventing tooth decay and stopping cocaine addiction, and simply dismissing those that disagree with you as "nay-sayers" doesn't bridge the gap.
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HUFFPOST PUNDIT
jsgaetano
Legum servi sumus ut liberi esse possimus
10:57 AM on 12/22/2009
And thanks to conservatives, our drinking water now both prevents tooth decay AND stops cocaine addiction!