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Jacob M. Appel

Jacob M. Appel

Posted: April 5, 2009 05:10 PM

Should We Really Fear Reproductive Human Cloning?

What's Your Reaction:

In his remarks lifting the ban on the federal funding of embryonic stem cell research last month, President Obama took pains to distinguish research cloning from reproductive cloning. According to the President, "the use of cloning for human reproduction" is "dangerous, profoundly wrong, and has no place in our society, or any society," and he promised to ensure that "our government never opens the door" to such a practice. What the President did not do was to explain precisely why he opposes reproductive cloning. Is his opposition solely based upon the health risks that cloning techniques, such as somatic cell nuclear transfer, may impose upon children born as a result of this novel technology? Or does he believe that human reproductive cloning ought to be prohibited even if it could someday be rendered as safe--or safer--than other forms of procreation? To some who oppose reproductive cloning, as polls consistently suggest that a majority of Americans still do, these questions may seem purely academic: As long as our society adopts the right policy, one might argue, why concerns ourselves with whether we are doing so for the wrong reasons or even for conflicting reasons? The reality of the legislative debates preceding state cloning bans--from California's 1997 prohibition to the statute enacted last week in Montana--is that much antagonism to reproductive cloning appears to reflect an inchoate, emotional and often illogical repugnance to the practice on the part of lawmakers, rather than well-reasoned and well-articulated opposition. What is actually needed is an unbiased assessment of both the perils and promises of cloning humans.

Most evidence suggests the reproductive human cloning, at the present time, would pose serious dangers to any children so produced. The frequency of birth defects and long-term health complications in cloned animals remains exceedingly high. These genetic disorders likely result from programming errors due to what biologists call "imprinting," and arise when the double sets of maternally- or paternally-derived genes in the embryo "speak" simultaneously. While scientists are currently working on reprogramming techniques, which would prevent these errors, the feasibility of such efforts remains largely uncertain. What is far clearer is that, if society's only objection to reproductive cloning is the danger that the technology poses to the offspring, then research to render human cloning safe should be pursued vigorously.

The most obvious benefit of reproductive cloning--if it could be rendered safe--would be as a source of transplantable tissues and organs. I certainly do not mean to suggest that cloned children would have any fewer human rights or should be treated any differently than non-cloned children. Quite the contrary: Much as children conceived in "test tubes" are morally and legally indistinguishable from children conceived in utero, any moral approach to reproductive cloning would ensure that clones were treated with the same respect and dignity as any other identical twins. However, parents frequently decide to produce additional offspring in order to provide matching bone-marrow donors for their critically-ill children. Pediatric kidney donations between living siblings takes place in many nations. For a family with a dying child, the prospect of using cloning to create a potential donor with a set of perfectly-matched genes--and ultimately, two healthy, lovable children--might be a godsend. The ethics surrounding such procedures are highly complex. Nobody should believe otherwise. However, one should never mistake the complexity of making a decision for its underlying morality. Certainly, there is a wide difference between believing that the possibilities of human cloning should be approached with wisdom and considerable caution, as do I, and deciding a priori that such potentially therapeutic opportunities should be dismissed out of hand. I cannot imagine that President Obama's remarks were intended to meant that, if reproductive cloning could be rendered safe for both mother and baby, and if it could save the life of a desperate sibling, it would still be profoundly wrong.

Individuals may wish to clone children for many additional reasons: some that strike mainstream society as highly reasonable, others that strike us as rather peculiar. Infertile couples might use the technology to produce children with some of their own DNA. A family who has lost a child in an accident might find some solace in cloning their lost son or daughter; the second kid would, of course, be a distinct human being from the first, with its own identity, but the sense of continuity experienced by the mourning parents might provide comfort nonetheless. The Raëlian Church has pursued cloning technology for religious purposes. As long as a scientific consensus exists that cloning is a health threat to the offspring, these individuals should not be permitted to risk bringing a severely disabled child into the world. I think most reasonable people would agree that when the health of children is at stake, we should set the safety bar high and take few unnecessary risks. However, if the times comes when scientists conclude that reproductive cloning can be conducted without a threat to the health of the offspring, then the burden will fall upon opponents to explain precisely why such a practice threatens human dignity or societal welfare. The cry of "we don't like it"--which has been used to justify opposing every aspect of human enlightenment from women's suffrage to gay equality--will simply not be a sufficient answer.

What has been lost in the rush to condemn reproductive cloning wholesale has been any meaningful effort to protect future children created through such a procedure. Whether the practice is legal or not in the United States, it will likely be only a matter of time before some determined scientist, somewhere in the world, creates a cloned human being. We need clear laws to establish the relationship between the supplier of the cloned DNA and the resulting progeny (eg. Are they siblings? Parent and child? What are the clone's inheritance rights?) We require guarantees that, if genetic defects do arise in such children as a result of cloning, treatment for these conditions will be covered by private health insurance. And we need careful regulation and funding to ensure that the procedure is rendered safe--if that can be done--before cloned embryos are brought to term. In short, we need legislation to ensure that any future cloned men and women will be treated with the dignity and humanity that they deserve.

In an ideal world, human reproductive cloning would be safe, legal and rare. I say rare because my guess is that the vast majority of people, myself included, would have little desire to raise cloned offspring. After all, it is now possible to clone pets dogs--but few of us would choose to spend a spare $150,000 on such a venture. Yet thirty-eight years after James Watson's seminal essay, "Moving Toward the Clonal Man," called for increased public debate on this promising and perplexing subject, I don't believe that we should be so quick to greet cloning technology with a permanent injunction. Instead, what human reproductive cloning requires at the moment is a yellow light, telling us to proceed with extreme caution, until we know with confidence whether the technology can ever be used to produce healthy babies.

 
 
 
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12:31 PM on 04/14/2009
I read with interest Jacob Appel's piece on human reproductive cloning. Appel states “While scientists are currently working on reprogramming techniques, which would prevent these errors, the feasibility of such efforts remains largely uncertain. What is far clearer is that, if society's only objection to reproductive cloning is the danger that the technology poses to the offspring, then research to render human cloning safe should be pursued vigorously.”

As any scientist in this field could point out, no matter how much preliminary work went into avoiding reprogramming errors, working with animal models, etc, there is ultimately the moment at which the experiments must involve humans. And there is no way to avoid the likely “disasters” along the way to perfecting the techniques that MIGHT ultimately avoid these terrible outcomes. Imagine doing with humans what we did with sheep before Dolly ultimately resulted (and even she herself was a most problematic example of “successful” reproductive cloning). In sum, there is no ETHICAL way to “get there” from here, because there is always that final requirement of human experimentation that is likely to involve some horrendous results no matter how much advance work is done. It is one thing to do this in experimental animal models and quite another in humans.
04:32 PM on 04/06/2009
Why is the cloning of humans bad? Huh? Are you kidding me?

There are some folks that just love to play with genetics - now our tomato is partially a fish (I kid you not), it is becoming difficult to get real corn, or unaltered samples of almost anything we eat. Now, we just engineer people. God forbid anyone should ever die!

You must be very bored to start cloning humans. This, as will be proven, is an evil process. Not in a religious sense, but in the "nothing good will come of it" sense. Once this door is opened, all sorts of sinister minds will begin to act out their sinister plots.

Bad idea!
04:08 PM on 04/06/2009
I oppose cloning and I admit it's largely on a visceral level. I find the notion very troubling. Maybe I've just read and watched way too many sci-fi books and movies. :-)

But I especially dislike the notion of cloning a person just to get an identical tissue match for bone marrow or a kidney transplant or whatever. If, as the author says, the clone is a unique human being entitled to human rights, do they have a say in whether their tissues are harvested? What if the clone is only an infant or toddler when the harvesting is done? I suppose it would be the parents' decision, but does that then essentially make the clone the parents' property instead of their child? We haven't even figured out where the line is between property and child for children born the old-fashioned way (i.e., see any arguments about religiously-minded people who don't want medical care for their minor children).

On a less serious level, I very much dislike the idea of a jerk like Donald Trump being able to clone himself so that we're always stuck with some version of him running around. But seriously, who decides who gets to clone themselves? Is it only going to be based on who can afford it? Is it going to be based on merit - only those with IQs over 180 get cloned? Is it going to be based on "genetic superiority"? Who decides?
04:29 PM on 04/06/2009
Are you allowed to take organs from your child? Even an egocentric monomaniac like DT would find it morally repugnant to evicerate his child/twin even to get good hair.
02:56 PM on 04/06/2009
I don't know why people get so illogical on the subject of cloning. Clones have been around as long as life has. Many animals reproduce asexually, producing identical copies; in humans a similar thing happens when identical twins are produced. Identical twins are born at the same time and grow up often in the same environment and timeline. They also share the same mitochondrial DNA inherited from their mother. However, everyone who knows such twins is aware of the differences between them.
Clones would be on a different timeline and environment from their parent and would not share mitochondrial DNA. They would be as legally separate as twins and could not have their individual rights diminished. Any talk of harvesting organs reeks of the worst kind of slavery.
04:28 PM on 04/06/2009
Not human clones.
03:28 PM on 04/08/2009
I think you have some of the most reasonable and logical commentary here.
01:09 PM on 04/06/2009
Science does not go backward. Science WILL go in this direction and my point would be, WE should do this, and be the leader in ALL stem cell science so that WE can direct the debate on ethical issues.

These things WILL happen in the future. Why not have America in charge?
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BlackJAC
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08:43 AM on 04/06/2009
You forget about all the eugenics issues the subject brings up. Need we watch GATTACA again?
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BCubedReg
Everything is possible
01:19 PM on 04/06/2009
It's not just Gattaca, it's movies and shows like "the Island", "Bladerunner", "Space Above and Beyond" and a host of others that challenge the moral argument against cloning and creation of other artificial types of life . Those created through cloning , invitro and A.I. have the potential of being designed specifically to be an exploited social class.

Personally, I am for cloning and just about any other scientific endeavor. But for every positive scientific descovery, there is waiting in the wind, someone ready to exploit that discovery for nefarious purposes; whether it be for body parts harvesting, sex for sale or slave labor.

The argument is never about can we do it but should we do it. There's always some ready to pervert the greatest advances of science.
03:57 PM on 04/06/2009
well said.
02:57 PM on 04/06/2009
Excellent movie.
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dadw5boys
Disabled Vietnam Vet
12:16 AM on 04/06/2009
Would our clones be subject to minium wage ????

Could the live in the barn ?

How would you dispose of the defective ones ?????
09:44 PM on 04/05/2009
i did not read the article but the answer is no the only reason it has such a big stigma is because of the religious nuts god created man blah blah blah
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08:01 PM on 04/05/2009
I can see where cloning of a human would create an intense dilemma for many religious people. Is the clone a human being, and if the answer is "yes", at what point in time did the initial cell become a human being?

There are many people who maintain that an ovum becomes a "person" from the moment of fertilization. If there is no comparable moment in the cloning process, then one could reasonably ask whether the clone is, indeed, even a person. Does the clone have a soul? Does the clone have more rights than a tumor? Could the clone be treated like a replicant, used as a slave? Would we be forced to consider an operational definition of what it means to be human?

These questions are not trivial.
09:45 AM on 04/06/2009
of course, clones would be human beings, but, from what I understand, human reproductive cloning, at this point, would be just plain cruel and irresponsible, not that that's ever stopped science before.
01:07 PM on 04/06/2009
But when does god "zap" a soul into this cell? Isn't that what the religious people insist? They say there is a separate thing called a soul that is zapped magically into all fertilized eggs.

If we can find out how and when THAT happens, we can solve lots of questions.

hahahahahahah!!!!!
07:14 PM on 04/05/2009
The opposition to human cloning is two fold. First, too many people are familiar with stories like Brave New World and 1984, and sci fi stories of cloning people in pods.

The second objection to cloning is purely a religious one, ie it is "playing God" or it devalues the sanctity of human life in the natural reproductive process. Never mind that these same people have no problem violating the sanctity of human life during war or promoting genocide against those who oppose us, namely the seeming entire Islamic population.

But, no one is talking about the potential benefits. The potential to harvest organs or blood plasma for lukemia patients. Genetically compatible stem cell research. There are a million potential possibilities to human cloning, and while we need to proceed with caution, as you say, we should never stop the evolution of scientific and medical progress.
03:00 PM on 04/06/2009
Harvest! From real people?
04:14 PM on 04/06/2009
depends on whether you think clones are "real" people. I wonder if they'd be invited to live in the "real America" we've heard so much about.

Having once made a decision to donate stem cells to a leukemia patient who I had never met (and likely will never meet), I can say that choosing to donate tissues is not a matter to be entered into without serious consideration.

It would be hideous to create a human being for the sole purpose of getting a kidney, part of a liver, some bone marrow, or whatever from them. Stem cell research holds out the promise of creating these kinds of tissues in petri dishes in labs. If we're that desperate for tissues, we should exhaust the possibilities of stem cell research long before we even think about cloning people for that purpose.