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Natural Genetic Engineering and Natural Selection: Perplexing Delusions of Certain Neo-Darwinist Advocates

Posted: 04/23/2012 7:32 pm

In my last blog, I received repeated accusations of being "anti-evolution" from John Kwok and Keith Roragen. These accusations puzzled me, and I tried to explain why I was puzzled in my online answers to them. But they continued to insist.

My basic argument on the blog (and in my book) was the following: We need to pay far more attention to non-random cell-mediated genome change ("natural genetic engineering") in evolution.

Here's what John Kwok said:

I must concur with Jerry Coyne's assessment of you: "My own theory is that the man simply doesn't understand the kind of population thinking in which 'natural genetic engineering' can result from garden-variety natural selection. (I often find that molecular biologists fail to grasp natural selection, even though it seems conceptually simple.)"

And here's what Keith Roragen said:

Where genome changes come from in the first place is irrelevant. Darwin had no knowledge of genomes. He didn't need it. Darwinism isn't concerned with how genomes change but how those changes propagate through populations and accumulate to form new species. You haven't even come close to explaining that.

Both John and Keith invoked natural selection and population genetics in a way that makes no logical sense. They seemed to believe that incanting "natural selection" would somehow invalidate what I said about the importance of natural genetic engineering. (Readers are invited to dig out the full exchanges and judge for themselves.)

The Jerry Coyne statement that John quoted does not even make sense within the context of the neo-Darwinian Modern Synthesis. Population geneticists recognize the need to use "mutation rates" and recombination events (i.e., genome changes) to generate new allelic variants and combinations as the raw material for selection. There is no way that natural selection can substitute for natural genetic engineering; by definition, it can only work after heritable change has occurred.

Keith simply sticks his head in the sand and introduces stubborn ignorance in place of explanation.

It is difficult to imagine how evolution could occur without genome change according to virtually any theory. Perhaps a purely neo-Lamarckian process, depending exclusively on epigenetic modifications, might conceivably generate heritable (and hence selectable) organism change without alterations to DNA sequences. But I do not think this is what my antagonists had in mind.

The curious responses to my position exposed a fundamental difference in understanding of biological functions between molecular geneticists and these particular proponents of population genetics. Because I can only speak for the molecular side, let me elaborate. I will leave it to John, Keith, and Jerry to explain their assertions.

Molecular geneticists recognize the essential roles of genome structures and multi-molecular networks for cell activities and for morphogenesis.

  • Cell reproduction would not happen without signals in the DNA for replication, for synthesizing and processing RNA, and for genome transmission to daughter cells.
  • Cells would not be able to survive the many changes they undergo, both internally and externally, without cell receptors, signaling molecules, and regulatory complexes.
  • Cells could not differentiate, form tissues, and carry out morphogenesis to produce multicellular organisms without genomic signals and cell networks.

To a molecular geneticist, evolution is the story of how essential genome structures and networks have changed over the history of life. DNA-based evolution science traces the histories of genome features among distinct life forms.

The basic fact is that natural selection can only pick out the most adaptive existing genome structures once they exist. There is simply no way, even theoretically, that population genetics and natural selection can account for how these structures and networks originated in the first place and then changed over time. That is why John's and Keith's assertions are so perplexing.

Novel genome structures have repeatedly played key roles in evolution of all aspects of biological function:

  • Proteins evolved to acquire novel functions by domain accretion and shuffling, a natural genetic engineering process.
  • New protein domains appeared in evolution by the incorporation of coding sequences from mobile elements ("exonization").
  • Protein coding sequences were amplified and diversified so that "protein families" can carry out the metabolic and regulatory processes characteristic of distinct species and higher taxa.
  • Regulatory RNA molecules evolved by a variety of natural genetic engineering processes, including reverse transcription and reinsertion of the newly made DNA into the genome.
  • Multicellular development depends upon intricate genomic systems like the Hox complexes, which are amalgams constructed from multiple coding and regulatory sequences; from the DNA record, it seems evident that bilaterally symmetric animals (including ourselves) could not have evolved without the assembly of the earliest Hox complex near the end of the Ediacaran period.
  • Species evolved in significant measure through changes in the cis-regulatory networks inscribed in their genomes.
  • Formation of new taxa frequently involved changes in chromosome number and structure.

(Thousands of references [including Scientific American articles] for these and other natural genetic engineering processes in evolutionary history can be accessed through clickable links at shapiro.bsd.uchicago.edu/evolution21.shtml.)

John, Keith, and Jerry have stated that I am mistaken (and dangerously misleading others) by expressing my position that natural genetic engineering is essential to evolution. If they wish to maintain that stance, then I think they need to explain why in detail. Fiat assertions and personal attacks are no substitute for rigorous argument.

 
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In my last blog, I received repeated accusations of being "anti-evolution" from John Kwok and Keith Roragen. These accusations puzzled me, and I tried to explain why I was puzzled in my online answers...
In my last blog, I received repeated accusations of being "anti-evolution" from John Kwok and Keith Roragen. These accusations puzzled me, and I tried to explain why I was puzzled in my online answers...
 
 
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11:10 AM on 05/12/2012
James;
2 decades ago I read a book called "Artificial Intelligence", a collection of papers on the subject. The final (?) paper was a speculative comparison of the structure of "silent/junk" DNA with neural networks, noting the apparent layering of structure and function, and drawing attention to the frequency distribution of matching sequences -- almost identical to that found in word frequency plots in a natural language.

I took this thought further, and began to refer to the (highly conserved!) non-coding DNA as the Operator's Manual for activation and alteration of the coding genome. A bit later, I began to refer to this as the inevitable result of "Intelligent Self-Design" and/or random natural selection!

Consider: if purely by chance a bit of junk DNA should have the fortuitous effect of trimming the "tree" of possible mutations in conjunction with some environmental signal, it would convey immense survival advantages to that genetic line. Accumulation of such "rules" would accelerate, and swiftly dominate selection processes. Layers, as in neural network "supervisory" layering, comprising meta-rules for lower layers, would arise and be swiftly refined and strongly conserved, also.

IOW, "intelligence pays" when it comes to evolution's mechanics, and would be an inevitable development. I also think that the communal gene-swapping pools of bacteria constitute a similar "Intelligent Self-Design" network.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
12:55 PM on 05/12/2012
Brian,

I think we are in agreement in principle but perhaps not in detail.

The agreed principle, I believe, is that cells and organisms possessing an orderly process of genome variation when it is needed will have greater success in overcoming selective challenges as they occur. This is what I have been calling natural genetic engineering, and empirical evidence for it is extensive. Note that orderly does not mean deterministic or prescient but simply tending to make useful changes at appropriate times.

Where we may disagree, I believe, is in how natural genetic engineering is regulated. I think we have clues in the complex multimolecular networks cells are known to use for sensing, signaling and making decisions about what they do with their genomes. But we still need more empirical and theoretical research before we can comprehend how these networks operate. The same is true, as far as I know, of neural networks.

Have I understood your point correctly?
08:35 PM on 05/13/2012
The mechanics are important, but there are two sticking points that need to be accommodated, IMO:
1) Much of the "silent 95" is conserved. This makes it de facto important, used and useful
2) Its implicit structure resembles neural web organization, as noted.

There are no "coincidences" at this level.

At the organism level, optimization of use of genetic resources is much enhanced by this kind of organization. At the species level, it permits development and dispersal of tactical and strategic improvements.

Intelligent is as intelligent does. Neuron-based intelligence is just one variety.

As for John's "natural selection" terminology below, it seems to me that the ability to trim and limit susceptibility to "random mutation" (leaving some parts of the genome more vulnerable "on purpose") is a huge multiplier of evolutionary effectiveness. There are trade-offs, as it precludes major changes that would be desirable, perhaps, such as adopting the octopus' retina by a mammal, but it makes substantial change workable with limited populations. It reminds me of the punk eek hypothesis in that respect.

Too much randomity is bad, as it demands impossible numbers. Not enough leaves you trapped in narrow channels.
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John Kwok
02:17 PM on 05/12/2012
Brian, both yours and Shapiro's explanations can be addressed via the "garden variety Natural Selection" which Coyne has asserted, by noting that genomic variation operates successfully within populations via differential reproductive success in which those with favorable traits are the ones most likely to reproduce and produced offspring able to survive until they, themselves, are able to reproduce. However, it remains to be seen how this could be explained in the context of multilevel selection or account for phenomena like evolutionary and ecological stasis. "Intelligence" and "Design" are more likely emergent processes arising from the genomic variation that is promoted via Natural Selection and genetic drift; not that they, themselves, are responsible for evolutionary change.

Moreover, Shapiro needs to explain why he thinks it is time for a "paradigm shift" in modern evolutionary theory, especially - as his colleague University of Toronto biochemist Larry Moran has noted - since we've known about mobile elements for decades and yet there wasn't any need to discard Natural Selection and random genetic drift to account for them. Nor does Shapiro's emphasis on "natural genetic engineering" address such fascinating issues as speciation and punctuated equilibrium. (I believe such a "paradigm shift" is needed, but one based on the principles stated by Stephen Jay Gould and Massimo Pigliucci, among others, not Shapiro's.)
08:40 PM on 05/13/2012
My term "intelligent self-design" is my attempt to encompass the explosive requirements for time and population turnover that reliance on point-mutation statistics requires. I thus tend to think of the mobile elements more as deployable resources rather than rolling cannon balls banging around the genome.
02:06 PM on 05/11/2012
Dr. Shapiro,

John Kwok is making a statement that it is the duty of science to "Trash creationism" and that you are negligent in that duty. Care to comment?

........."trashing creationism". (Which, I might add, not only myself, but Scott Hatfield, Allen MacNeill, Massimo Pigliucci and many other scientists and science-literate members of the public regard as something that is unfortunately necessary; a duty that has eluded you given your support of your Huffington Post creationist fans as well as those at the Discovery Institute, the notorious "think tank" of Intelligent Design creationism.) - John Kwok
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John Kwok
02:16 PM on 05/11/2012
The phrase "trashing creationism" was lifted from Suzan Mazur's interview with James Shapiro; those are her words, not mine, in discussing how Jerry Coyne began his Rockefeller University lecture. However, Shapiro's odd behavior in defense of you and other Huffington Post creationists stands in stark contrast with the views expressed by myself, Scott Hatfield, Allen MacNeill and others. Unfortunately, Shapiro is being negligent in not condemning creationism, both here, and elsewhere, especially at the Discovery Institute's Evolution News & Views website.
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John Kwok
03:07 PM on 05/11/2012
If you include the entire quote, Rivera, it is most definitely Shapiro's duty, since creationism is a "dead science":

"Nor should anyone consider Mazur as credible when she refers to Coyne's lecture as one that began with 'trashing creationism'."

My critique was aimed more at Shapiro's willingness to be interviewed by someone like Mazur, especially when she isn't viewed as a credible science journalist by yours truly, Scott Hatfield, and others who shall remain nameless.
03:38 AM on 05/10/2012
Reductionism is an ideology of science and does not reflect science itself which must always maintain its grasp of things in relation if it is to know what it is doing. Religion is an ideology that has always opposed reductionism and for good reason seen it as an affront to what it is to be human. Unfortunately religion has made the opposite mistake of making an ideology out of its assertion of the whole in opposition to the part.

It seems that Shapiro is simply making explict something that science has always done in practice but not realised in theory and that is that wholes and parts are impossible to really understand without reference to one another.

What science does is it takes nature apart reassembles it and makes it revolve around us. The idea that science can reduce us to bits and pieces and disassemble our sense of human purpose into fundamental particles of matter is rightly resisted by religion but for the wrong reasons.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
05:54 PM on 05/10/2012
Marty,

I have the impression you are referring to comments I made in my recent interview with Suzan Mazur on Counterpunch (http://www.counterpunch.org/2012/05/07/the-evolution-paradigm-shift/). Is that correct?
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John Kwok
08:58 PM on 05/10/2012
Suzan Mazur incorrectly describes the National Center for Science Education as an "appendage":

"I am reminded of the keynote speaker of the Rockefeller University Evolution symposium — University of Chicago biologist Jerry Coyne — who stood before an audience of distinguished scientists in the spring of 2008 to do damage control, first trashing Creationism and then declaring that he could cite 300 examples of natural selection but didn’t have enough time to do so. The speech was arranged by the National Center for Science Education — an appendage of the American Association for the Advancement of Science."

I attended that symposium (and met Mazur), and I know that Jerry Coyne's "speech" (lecture) was not paid for by NCSE.
02:28 AM on 05/11/2012
Yes, or at least partly. Also in response to some of the comments below.

I am generally coming from a view of science propounded by Jacob Bronowski many years ago. He emphasises the relation between science and human values.

There is science and there is scientism that stems from mistaking the way that science presents its ideas with scientific method itself. The way that science presents its ideas can encourage the idea that the truths of science are a kind of mathematical certainty etc. A kind of superhuman truth the ordinary human world becomes a kind of illusory realm where scientific facts trump human values every time. Bronowski shows where this leads in episode 11 of his TV series the ascent of man.

The philosopher Wittgenstein also set himself against scientism where science lays claim to be the only truth. He failed to see I think the distinction that Bronowski made between science and scientism which sent him off on a bit of a mystical tangent.

Reductionism is an ideology. All ideologies have a grain of truth to them or no one would believe in them reductionism has been enormously fruitful but it and its view of the world as a humpty-dumpty-verse have had their day.
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John Kwok
10:57 AM on 05/11/2012
I think Bronowski is mistaken in his criticism of science, though there are some, like, for example, Coyne and Dawkins, who have subscribed to "scientism" via their advocacy of militant New Atheism. I concur with physicist Lisa Randall's observation that science and faith are different ways of knowing. (A view shared by Vatican Astronomer - and Jesuit Brother - Guy Consolmagno, among others.) As for James Shapiro's view on the current state of evolutionary biology, it is one not widely held by his colleagues, and that, more than anything else, may be why his latest book is being ignored by Science and Nature, among others.
08:58 PM on 05/11/2012
To be honest with you I actually was reading some of your posts as if you were an exponent of said scientism. Now unfortunately, having found something to agree about. II have to take issue with you when you say that science and religion are different ways of knowing.

I must confess that I had no idea, based on your posts that you harboured such relativistic thoughts. Bronowski proposed the idea that science enabled us to act without fear. As with many of his formulations this sounds like a simple idea. It's only when you start to think about what it might be like to act in a world full of fear that you start to see the point of what it is he is getting at. In this respect both scientism and religion can be held to account.

I think there is a phrase that deals with your last point. In philosophy there is the idea of an ad hominem argument. It is widely agreed to be fallacy. Obviously one has to discriminate but I have the feeling that the is something here that needs to be said.

By the way I don't think that scientism is a disease of scientists. It is more a problem with the way that it is perceived in wider society. If someone says ' it is a scientific fact' you are supposed to fall to your knees. I personally only kneel before my own conscience, and even then only sometimes.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
12:26 PM on 05/03/2012
Just to clarify certain points.

My original post asked for an explanation of Jerry Coyne's statement cited repeatedly by John: "My own theory is that the man simply doesn't understand the kind of population thinking in which 'natural genetic engineering' can result from garden-variety natural selection. (I often find that molecular biologists fail to grasp natural selection, even though it seems conceptually simple.)"

There is still no answer from anyone on how "garden-variety natural selection" can account for the appearance of DNA structures underlying many evolutionary innovations. As I said, I am still waiting for this explanation.

In discussing the active 19th Century history of evolutionary science, I cited Wainwright's web site for documentation of pre-1859 thinking on the subject. Wainwright's bias against both Darwin and Wallace as originators of evolutionary ideas is explicit. John cited a BCSE link as evidence that Wainwright is an ID advocate, but clicking on the link turned up a different evaluation: Wainwright is not a Creationist, is a religious agnostic, but is open to considering intelligent design ideas.

The major issue of how creative a force natural selection can be when it only acts after hereditary variation has been generated remains largely ignored in the recent back-and-forth. My position is that the production of hereditary variation in the form of genome changes is the real creative force in evolution. It would be good to hear reasoned arguments addressing that position, pro or con.
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Wendell Read
03:07 PM on 05/03/2012
In your book you state: "A number of molecular biologists ... have proposed that ... viruses serve as sources of novelties that can later be adapted by cells" (page 133). From the abstract of one of your references:

"It has been suggested that replacement of cellular proteins by viral ones also occurred in early evolution of the DNA replication apparatus and/or that some DNA replication proteins originated directly in the virosphere and were later on transferred to cellular organisms. According to these new hypotheses, viruses played a critical role in major evolutionary transitions, such as the invention of DNA and DNA replication mechanisms, the formation of the three domains of life, or else, the origin of the eukaryotic nucleus."

"The origin of viruses and their possible roles in major evolutionary transitions."
Forterre P.

It would seem reasonable that the insertion of 'functioning' genome sequences 'purified' by natural selection would provide material more suitable for the elocutionary process that would random 'errors' filtered by natural selection.
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John Kwok
10:07 PM on 05/03/2012
In the words of the noted Columbia University philosopher of science Philip Kitcher, Intelligent Design should be viewed as "dead science" since it was considered and rejected by Darwin's teachers and contemporaries. For Wainwright to be open to Intelligent Design concepts is simply not a tenable position for any scientist to take. Moreover, as I have noted here already, Darwin had conceived of Natural Selection by 1842, fully anticipating the "Origin of Species", and not - as Shapiro has asserted incorrectly - that Darwin didn't know of Natural Selection until he saw Wallace's 1858 paper.
03:37 PM on 05/07/2012
If you only could see how ridiculous you are to those of us on the non-committed sidelines.
12:10 PM on 05/03/2012
Congatulations Dr. Shapiro,

I am excited for you. There is an excellent write up on you at evolutionnews.org.

".......He continues to win our admiration, while evoking some poignancy as well."


"In one post that got a fair amount of attention he had some sensible things to say to fellow evolutionists. Rather than hide behind "absolutist statements like 'all the facts are on my side,'" as his University of Chicago colleague Jerry Coyne does, Shapiro advocates "active engagement" with Darwin critics. Enter into the controversy over evolution, he says, rather than pretend it doesn't exist. "
http://www.evolutionnews.org/2012/05/more_reasons_to059221.html


What your detractors dont seem to grasp is that eventually the millions of people who would otherwise reject evolution, will read your book and accept the empirical evidence of "natural genetic engineering".

Your detractors meanwhile, will pretend as always that there is no issues in evolution and and continue try to shove it down our throats. The definition of insanity is doing the same thing over and over but expecting different results!

Regardless, ultimately in science the empirical evidence prevails!,


.
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weisschr
06:09 PM on 05/10/2012
I sincerely doubt that any active scientist would consider praise from the Discovery Institute's web site, 'Evolutionary News and Views' a worthwhile career objective. If Shapiro thinks this is a good thing, that speaks volumes.
08:22 PM on 05/10/2012
Gee, I think Shaprio is focusing his attention on the millions and millions of people in the general public who will be very interested in hearing that evolution isnt driven by "Random mutations", and not on a couple of insignificaant detractor scientists who the general public doesent either respect, know, or care exists!

That's a good thing and speaks volumes!
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John Kwok
11:25 AM on 05/02/2012
James Shapiro's latest essay and his subsequent commentary have merely reinforced the harsh, but accurate, assessment that Jerry Coyne wrote recently in response to some of Shapiro's earlier Huffington Post essays, of which this latest essay should be viewed as yet another rebuttal to Coyne.

I am especially concerned with Shapiro's substantial misreading of Darwin's life and work, having claimed that Darwin didn't conceive of Natural Selection until Darwin had received Wallace's essay in early 1858,demonstrating that Wallace had conceived of it independently of Darwin.

However, it can be shown via Darwin's own notebooks that he was thinking seriously of Natural Selection by 1840, having been influenced by his reading of Malthus:

http://www.amnh.org/exhibitions/darwin/idea/theory.php

And by the late summer of 1842, he had stumbled upon and coined the term "Natural Selection":

http://www.amnh.org/exhibitions/darwin/idea/adding.php

Unfortunately this is just one of many examples where I agree with Coyne that Shapiro may be "dangerously misleading" Huffington Post readers into thinking that there is something seriously wrong with both modern evolutionary biology and current evolutionary theory. (As an aside, I think current evolutionary theory will be eventually replaced, but not along the lines which Shapiro believes.)
10:16 AM on 05/02/2012
"Dr. Milton Wainwright whom you cite has been identified as an Intelligent Design apologist, according to my friends at the British Centre for Science Education:
Therefore I don't regard Wainwright as a credible source"

Wow, just wow! If we replace the words "Intelligent Design apologist" with say black, woman, gay, then it becomes very obvious as to the non-science issues challenging Shapiro!
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John Kwok
01:21 PM on 05/02/2012
Yours is a most illogical statement, Rivera. Hope you have opted to take a look here:

http://www.ncse.com/evolution

http://www.ncse.com/religion

Not only is Wainwright an Intelligent Design apologist, he is also a terrible historian of science since his allegations with regards to Darwin's work were repudiated years ago. State of the art thought with regards to Darwin's impact on science can be found here:

http://www.amnh.org/exhibitions/darwin
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Wendell Read
02:33 PM on 05/02/2012
John,

Can you give us an example of a statement by Wainwright that has been refuted?
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John Kwok
02:56 PM on 05/02/2012
Wendell, I can do even better, and point to this link as proof that Darwin had a full understanding of Natural Selection by 1842:

http://darwin-online.org.uk/content/frameset?itemID=F1556&viewtype=text&pageseq=1

Here's also a revealing quote from someone who has posted succinct informationn on those who had conceived of evolution before Darwin:

"Although Charles Darwin was not the first person to consider that life on this planet evolved, it is important to keep in mind that he was the first to come up with a viable working mechanism on how it happened."

You can look at that quote and other related information here:

http://www.aboutdarwin.com/literature/Pre_Dar.html

Speaking of looking up information, I hope you've begun studying the contents of:

http://www.ncse.com/evolution

http://www.ncse.com/religion
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Wendell Read
11:36 PM on 05/02/2012
John,

First I want to thank you for the references you have provided. All of us, without exception, benefit by by examining the way others understand scientific principles, especially when they see things differently than we do. However, your failure to provide examples of Wainwright's statements which have been 'refuted' brings into serious question your statement "his allegations with regards to Darwin's work were repudiated years ago".

Indeed, we can conclude, contrary to your assertions, that Wainwrights historical analysis of the development of evolutionary science is accurate any worthy of our attention. This is to be expected, as Prof. Shapiro's credentials and record of scientific publications attest to his knowing what he is talking about when he cites Wainwrights material as accurately describing the development of evolutionary thought.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
09:55 PM on 04/29/2012
John has claimed that Darwin and Wallace established biological evolution. In truth, there were a number of earlier evolutionists:

Erasmus Darwin, Geoffroy Ste. Hillaire, Jean-Baptiste Lamarck, William Lawrence, Robt Grant, Robert A. Chambers, Richard Owen and William Lawrence.

Moreover, the idea of natural selection was articulated before Darwin and Wallace by at least three scientists: William Charles Wells, Patrick Matthew, and Edward Blyth.

There is an interesting web site that presents all the significant propositions from Origin of Species published prior to 1859 (http://wainwrightscience.blogspot.com/).

In other words, as many people pointed out at the time, there was nothing truly novel in Origin of Species, and Darwin neglected to properly acknowledge his precursors, including his own grandfather. The impact Origin had was due more to the social standing and scientific prestige of its author than to the originality of its contents.
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John Kwok
10:32 PM on 04/29/2012
Darwin and Wallace were the first ones to develop a scientific theory on the evidence for biological evolution, which others, including Ernst Mayr have noted. None of those whom you cite devoted the years of time that both did in studying tropical diversity, and, in Darwin's case, conducted experiments to confirm various aspects of his version of the Theory of Evolution via Natural Selection. Claiming that Wells, Matthew and Blyth deserve credit for stumbling upon Natural Selection is poor history of science scholarship at best; quite disingenuous at worse. The only one of those whom you cite who had a substantial evolutionary theory was Lamarck, but he did not have a persuasive evolutionary mechanism nor was he able, unlike Darwin and Wallace, to provide substantial supporting evidence.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
03:06 PM on 04/30/2012
John,

Although Wallace was more modest, Darwin did claim to have solved the problem of origin of species. We know his explanation had to be at best only partial because of his ignorance of heredity. The Modern Synthesis tried to correct that in the first half of the 20th Century, but that attempt was also doomed because of the ignorance of how hereditary variation operated. Today, we are making progress now that we know about natural genetic engineering as the source of much (but probably not all) heritable change. At each stage, conceptual reformulation has been necessary to incorporate new knowledge. I hope we can agree upon that.
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John Kwok
04:07 PM on 04/30/2012
Sorry James, he didn't ignore heredity. He had no mechanism to account for it. Your misreading of the "Modern Synthesis" is a bit bizarre to say the least. (And no, I am not defending it since I agree with Allen MacNeill that it neglects multilevel selection and other aspects of biological evolution.) How does "natural genetic engineering" differ from Intelligent Design, especially when you admit that it could produce "irreducibly complex" structures?
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John Kwok
10:35 PM on 04/29/2012
Dr. Milton Wainwright whom you cite has been identified as an Intelligent Design apologist, according to my friends at the British Centre for Science Education:

http://www.bcseweb.org.uk/index.php/Main/MiltonWainwright

Therefore I don't regard Wainwright as a credible source.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
09:28 AM on 04/30/2012
John,

Yet again name-calling rather than substance. If Wainwright's evidence is flawed, explain.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
10:52 AM on 04/30/2012
Quoting the link you give:

Dr Milton Wainwright is a senior lecturer in molecular biology at the University of Sheffield. Contrary to some claims by creationists and IDers, Wainwright is neither an ardent IDer nor a creationist. He has, though, made it clear in public that scientists should be open to the concept of Intelligent Design. Wainwright has also said that he is, from a religious viewpoint, agnostic.

He does, however, appear to be open to Intelligent Design and, indeed, has not made up his mind about it. Some may take the view that he is now, post-Dover, openly sitting on the fence about it.

His academic position is confirmed at http://www.shef.ac.uk/mbb/staff/wainwright

This letter from Milton to the Times http://www.timesonline.co.uk/article/0,,59-1625988,00.html demonstrates that he is no creationist.

This letter to the Independent confirms that he is an agnostic: http://comment.independent.co.uk/letters/article327971.ece
08:54 PM on 04/29/2012
John you wrote...
"James Shapiro is "dangerously misleading others" when those who support his views here are Intelligent Design creationists Lee Bowman, Perry Marshall, Peter Rivera and THEMAYAN, and other creationists like Wendell Read. Several of us, including Scott Hatfield, myself and Allen MacNeill find this association both problematic and worrisome"

I know the man is not an ID'er or a creationist. I heard him speak on this issue in a lecture and he made this clear. This goes back to the point that I made earlier, that if in someway an IDer agrees, then the information no matter how relevant becomes spoiled goods, and the originator of the data becomes a persona non grata. In my opinion, this kind of "a friend of my enemy is no friend of mine" attitude does not belong in science. Politics yes. Science no. I think this also says volumes about the kind of mindset that seems so pervasive today concerning this subject. By the way, I also agree with many things that Darwinist have said including Darwin himself. I spoke earlier of his great work showing how finch beaks could vary through the process of natural selection.

I continue to notice how you are more prone to insult or question the intelligence (and to be more concerned with the perceived motives) of others than to respond to any points in a logical fashion. My motive is to search for truth and accuracy in science even if it's politically incorrect.
05:56 PM on 04/30/2012
John, for all the education you claim to have under your belt, you dont seem to realize that quote mining means quoting someone out of context. I have not done that. I.e., if I had tried to portray Gould as an ID'er etc., using an out of context quote to do that, then you would have a point, but I didn't. You dont seem to understand the definition of this term. You also claimed that Gould and Eldredge only coined the frame punctuated equilibria, again you were wrong. I googled your name, and John, your reputation seems to precede you. In this case I could only wish it was in a positive light, but then I would only be lying to you and myself.
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John Kwok
09:59 AM on 05/01/2012
You can still quote mine someone by citing something AND NOT UNDERSTANDING what you are citing. That is still quote mining. I doubt you understand what "geographic speciation", "punctuated equilibrium" or "phyletic gradualism" are. You have discussed "statistical probabilities" regarding Penrose's probability calculations for "fine-tuning" of the Universe when that phrase is inaccurate since he did not have any data for which he could conduct statistical analysis; my understanding is that all he did was to calculate the likelihood that "fine tuning" occurred, period.

With respect to punctuated equilibrium, the historical record is this. Eldredge originally came up with a version of it during the course of his Ph. D. dissertation research on the Devonian trilobite Phacops, realizing that he could apply Ernst Mayr's theory of allopatric speciation. He and Gould collaborated on that seminal 1972 paper, and in the process of writing it, Gould coined the term "punctuated equilibrium". Later they developed the theory further by suggesting that it contradicted substantial portions of the Modern Synthesis Theory. (I've only accused you correctly of misquoting Gould, period.)

Too bad you wasted your time in searching for me online. (I can assure you that Scott Hatfield, Todd Stark and Allen MacNeill, among others, would strongly disagree with whatever nonsense about me that's been posted.) You could have used your time far more wisely by reading Ken Miller's website, AMNH Darwin exhibition website, NCSE's website, and Carl Zimmer's website. Obviously your priorities are misplaced by not looking at them.
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John Kwok
10:08 AM on 05/01/2012
THEMAYAN, here's some links for you to look at the content with regards to the science of evolutionary biology, which you could have read YESTERDAY instead of looking me up online:

You could start here at the American Museum of Natural History's "Darwin" exhibition website:

http://www.amnh.org/exhibitions/Darwin

and then, once you've studied that, I would recommend looking at the sections on "evolution" and religion here:

http://www.ncse.com/evolution

http://www.ncse.com/religion

and finally you should study the content posted here:

http://evolution.berkeley.edu/evolibrary/home.php

You should also look at Ken Miller's web page:

http://www.millerandlevine.com/km

And lastly, at Carl Zimmer's:

http://www.carlzimmer.com

I strongly advise you to look at all of these since you've displayed consistently, a profound ignorance of science and the scientific method, as your HuffPo comments on the "fine tuning" of the universe, the "errors of Darwinism", probability and statistics and paleobiology demonstrate. Trying to smear me isn't going to work since you are simply displaying your profound ignorance of science, scientific methodology, and the history of science.
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Wendell Read
05:06 PM on 04/29/2012
Allen MacNeill makes makes an interesting distinction between the teleology we see operating in living things and the teleology which would be in evolutionary mechanisms were it to exist there. Science has no problem countenancing teleology in the operation of organisms since it can easily be explained by information "encoded in a previously existing program". Teleology in evolutionary mechanisms is another matter: were it to exist it would seem to imply at 'external agent' of some sort, and it is difficult to see how such an agent would not be supernatural.

Shapiro however provides a different perspective with his concept of natural genetic engineering. He has shown that cells are capable of modifying their genomes in response to environmental challenges. In other words, the cells themselves in this respect are agents of change. Perhaps evolution is mainly driven by genome changes engineered by the cells themselves. If so we would have teleology in evolutionary mechanisms, not driven by an external (supernatural) agent but in a completely 'natural' way, engineered by the cells themselves.

This of course raises an obvious question: How are cells able to do any natural genetic engineering at all? Our current inability to answer this question is a reason to try to find the answer rather than assert that it does not happen. Current data show it does happen.
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John Kwok
05:59 PM on 04/29/2012
Considering that you don't support common descent, claim that there are serious problems with the Phanerozoic fossil record, and believe that there is something "dogmatic" about "Darwinism" - when all that Darwin and Wallace did was to establish firmly the fact of biological evolution and then propose independently of each other, Natural Selection - then your observation of Shapiro's research borders on breathtakingly inane incredulity. Moreover, noted evolutionary developmental biologists like Sean B. Carroll and his students are demonstrating that the real "agents of change" are Hox genes, not entire cells.
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Wendell Read
08:36 PM on 04/29/2012
Thank you for your thoughtful reply.
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John Kwok
08:50 PM on 04/29/2012
Wendell Read, I hope you devote your time to reading the information on evolutionary biology that I noted earlier. You could start here at the American Museum of Natural History's "Darwin" exhibition website:

http://www.amnh.org/exhibitions/Darwin

and then, once you've studied that, I would recommend looking at the sections on "evolution" and the religion here:

http://www.ncse.com/evolution

http://www.ncse.com/religion

and finally you should study the content posted here:

http://evolution.berkeley.edu/evolibrary/home.php
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James A. Shapiro
Author "Evolution: A View from the 21st Century
10:10 PM on 04/29/2012
Wendell,

Permit me to disagree. To a considerable degree, we know down to the level of specific chemical bonds HOW cells carry out natural genetic engineering. References on this are in my book and online at http://shapiro.bsd.uchicago.edu/ExtraRefs.MolecularMechanismsNaturalGeneticEngineering.shtml.

Where we remain ignorant is in understanding how the products of natural genetic engineering succeed in encoding novel functional systems with probabilities high enough to help generate the diversity of life we know to have existed on earth.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
10:45 AM on 04/30/2012
The link in my reply to Wendell does not work as formatted, probably because of the line break. Try pasting it into the address bar on your browser. Make sure to delete the period at the end.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
11:03 AM on 04/29/2012
I'm sad to say that the comments on this blog seem to have degenerated into ad hominem attacks rather than substantive arguments.

I started by asking how the abundant evidence for natural genetic engineering at key stages in evolution could be explained as the result of natural selection, which can only act upon pre-existing variation. That question remains unanswered, and I think the reason is that no satisfactory answer can be given.

Arguing over who believes in what philosophy, who are the most "eminent" evolutionists, and who is the most credible science journalist are diversions from the main question: How do we account for functional innovations in the course of evolution? That's where the science is.
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John Kwok
11:44 AM on 04/29/2012
None of your supporters are really interested in "how do we account for functional innovations in the course of evolution". They are instead, quite delighted that a notable University of Chicago biologist is attacking the "Neo-Darwinism Dogma", expressing sentiments that they, as evolution denialists, love to hear.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
01:15 PM on 04/29/2012
John,

As for making ad hominem attacks and neglecting the science, just take a look at what you just wrote. Let's try to elevate the tone and deal with the issues.
07:01 PM on 04/29/2012
I think Shapiro's stament below is a very important topic among itself.

"That question remains unanswered, and I think the reason is that no satisfactory answer can be given"

My own personal take on it is, why is that? Its interesting that people like Carl Sagan or Michio Kaku could speak of type 2 and 3 civilizations. Francis Crick didn't get much flack from anybody for proposing Directed-Pan Spermia. We have the SETTI project with billions spent of the last forty years, and no one is going on with a hunt, claiming that science should not dabble in the supernatural. Because everyone knows little Green or Gray men are real, but fairies and leprechauns are fake. Yet when when we just speak of the possibility of teleological origin, just the implications alone are enough to get you tard and feathered in halls of academia. Just maybe, like the 18th century scholarly sceptic who thought that the concept of a telephone was supernatural and therefore outside of the realm of science, was as ignorant then as we are today. I.e. maybe we dont understand the natural world as much as we think we do and therefore refer to what we dont understand as supernatural.
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John Kwok
08:12 PM on 04/29/2012
Actually, you're mistaken about Crick. He did receive ample flack - and deservedly so - for proposing his panspermia hypothesis. As for Carl Sagan and Michio Kaku (whom I have met), they are making informed speculation about the search for intelligent life based on what they know insofar as cosmology and planetology has demonstrated based on their suitable scientific data. As for your citation of "teleological origin", you are merely employing a dishonest creationist rhetorical trick I have seen from creationists countless times. (Under no circumstances can you assume that Allen MacNeill would agree with you since I know he's as much a steadfast opponent - as I am - of creationism and of the ongoing tactics being used by you and your fellow creationists.)
04:28 PM on 04/27/2012
"It is a mistake that some biologists ignore the Modern (""Neo-Darwinian") Synthesis since it remains the best, most comprehensive, scientific statement with regards to our understanding of biological evolution and biology"

John,

How do you ignore a monolith or central dogma? I.e. something thats been shoved down your throat since grammar school. As for your other point, I might actually agree with you on your statement above. However, my point is that a theory which is so outdated, in cohesive, weak and inadequate in light of 21 century data, and yet which can still be regarded as the "most comprehensive scientific statement" …..says it all. I know many will disagree, and that's fine, but if you don't have a sound theory, then all your left with is a handful of educated guesses. The amount of failed predictions relating to the modern synthesis are numerous. Again all I ask is, Will the Real Theory of Evolution Please Stand Up?
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John Kwok
09:11 AM on 04/28/2012
I'm not defending the Modern Synthesis, or else I wouldn't have written this: "However, I agree with Allen MacNeill that we will need an 'Extended Synthesis' of the kind proposed by Stephen Jay Gould and Massimo Pigliucci." Despite its imperfections, the Modern Synthesis has been far more successful than you are willing to admit, relying instead on a sarcastic comment from mediocre science journalist Suzan Mazur. Your assertion on the "amount of failed predictions" doesn't quite register with a significant body of research that has been produced in population ecology, evolutionary genetics, genomics, paleobiology and even some of evolutionary developmental biology since the centennial of the original publication of "On the Origin of Species".

In the late 19th Century, physics was in a far worse state than biology is today. Having realized that Classical Mechanics was failing to explain the wave-like behavior of light, physicists didn't throw their hands up in the air and opt to quit, realizing that all they had "left with a handful of educated guesses" as well as substantial data pointing to grave issues with Classical Mechanics. They continued to do science, accumulating data that would later be a much better fit with the theories proposed by Einstein and Planck. For you to imply that current biological science is worthless because of the "falied predictions" of the Modern Synthesis, really demonstrates that you, despite your claims to the contrary, really don't understand science well. Henceforth, read Carl Zimmer, not Suzan Mazur, please.
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John Kwok
09:30 AM on 04/28/2012
Your observations really betray your lack of understanding about science. Remember, I said this with respect to the Modern Synthesis:

"However, I agree with Allen MacNeill that we will need an 'Extended Synthesis' of the kind proposed by Stephen Jay Gould and Massimo Pigliucci."

If the Modern Synthesis is so unsuccessful, then explain why paleobiology has flourished, in part, by applying population ecology theories to analyze and interpret diversification patterns in the Phanerozoic Eon (last half biillion years of Planet Earth's history)? Or the rise of molecular systematics as a powerful tool in understanding the "tree of life"?

If anyone is being dogmatic, THEMAYAN, it is you by making false and misleading statements and relying upon the words of mediocre science journalist Suzan Mazur. You would be better served reading Natalie Angier, Cornelia Dean, Faye Flam, and especially, Carl Zimmer's extensive popular science writings pertaining to biology, and especially, biological evolution.
02:17 AM on 04/26/2012
Well then there you go Scott. If a creationist or IDer takes any utterance critical of the current axiom, or even anything that questions the limitations of some of its constructs and runs with it, then the information no matter how relevant automatically becomes spoiled goods.
This type of reasoning has always puzzled me, and I only spoke of Mazur to accentuate a point, and the point is, that there are many dissenters out there who feel the modern synthesis is outdated, including atheist and agnostics alike who have no religious bone to pick.

I promise this will be the last mention of Suzan Mazur alias the Messenger of Doom, so let me just summarize by saying that your statement kind of reminds me of Massimo Pigliucci who actually wrote Mazur and commented on what a good article she had written. At least until IDers ran with the story, and then once again it became contaminated and she instantly became a persona non grata. This kind of religious like fervor in itself reminds me of the fifties when anyone who dare question the government was accused of being a communist. Only now, its creationism that puts you on the sh#% list. The real kicker is, that I neither said a word about creationism or ID.
08:55 AM on 04/26/2012
Mazur is no creationist; she's just a writer who exposed the extremely fractured nature of current evolutionary theory, as debated by real scientists at real meetings. You should make no apology for mentioning her.

The "contamination" you describe --- "if our enemies like it, it must be evil" is exhibit "A" of good old fashioned prejudice. And as Ron my father-in-law likes to say, "You can't reason with prejudice."

The only way to fight the religious fervor of the Darwinian old guard is not not give in to their bullying and intimidation. Otherwise you imply that their prejudice is acceptable and normal.
11:13 AM on 04/26/2012
"Well then there you go Scott. If a creationist or IDer takes any utterance critical of the current axiom, or even anything that questions the limitations of some of its constructs and runs with it, then the information no matter how relevant automatically becomes spoiled goods."

If we consider Shapiro's experiance here at Huff Post, Its becoming readily apparent that this treatment extends to any scientist who doubts some evolutionary mechanisms and proposes theories that threaten their philosophical view of life!
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James A. Shapiro
Author "Evolution: A View from the 21st Century
12:33 PM on 04/26/2012
Philip,

Don't cry for me, Rivera. The attacks just present an opportunity to restate the new data and repeat the arguments for a necessary rethink of evolutionary theory.
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John Kwok
01:00 PM on 04/26/2012
No, Scott and I are concerned that creationists like yourself are misinterpreting Shapiro's words, which do not "threaten [my] philosophical view of life.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
03:57 PM on 04/25/2012
John,

You ask "5) Explain why Natural Selection shouldn't be viewed as an Evolutionary Law in much the same way that Van Valen and Rosenzweig's concept of the Red Queen is."

I don't believe in immutable Laws of Nature. All scientific explanations are human creations and subject to change as we learn more about the natural world. If Newton couldn't get it right in a fundamentally unchangeable way, what hope is there for the rest of us?

In addition, as I explained in the earlier blogs that so distressed Jerry Coyne, I think the importance of natural selection has been greatly exaggerated. Moreover, many neo-Darwinists (like Jerry) invoke natural selection as a Deus ex Macchina to solve problems they really are not in a position to clarify.
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John Kwok
10:48 AM on 04/26/2012
I think it is fair to assert that with some scientific theories, the evidence is so overwhelming that they can be viewed as scientific laws. This is especially true for Gravity, but it is also true for both Natural Selection and the Red Queen; though with the former, I agree with you and Allen MacNeill that it should not be viewed as the primary mechanism of biological evolution. (So your characterization of me as a Neo-Darwinian advocate is not accurate.)
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James A. Shapiro
Author "Evolution: A View from the 21st Century
06:00 PM on 04/26/2012
John,

I'm confused. Which "Law of Gravity" are you indicating? Newton's expired early in the 20th Century, and people are working hard to replace Einstein's with a quantum version.

Could it be that you are confusing observation (attraction between massive bodies) and a human abstraction (gravity) that changes with the progress of science?
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John Kwok
06:06 PM on 04/26/2012
The law of gravity that was Newton's and then recognized as a special case under Einstein's; in much the same way that the Darwin and Wallace Theory of Evolution via Natural Selection was subsumed within the Modern Synthesis Theory of Evolution.
03:25 AM on 04/27/2012
John, I don't think anyone disputes NS. Darwin did some great work. He showed us how NS could account for variation in beak sizes
among the Galapagos finches and so forth, but what he nor anyone else could do (aside from educated guessing) is tell us how finches got here in the first place. Maybe your right. Maybe NS should be regarded as a law. l'll leave that to others to decide and only go one to say, that it's not NS that is in dispute, but the role that NS plays in the larger scheme of things.

I find it interesting that you contend that the name we dare not mention knows little of biology when in fact, with the exception of evolutionary biologist, most biologist can do their work and do it very well without ever hearing or even knowing about the neo Darwinian synthesis. Evo devo is a specialized field and its not surprising that many evo devo are also some of the biggest critics of the neo Darwinism/the modern synthesis.
I.e. many biologist who are actually in the field of evolutionary development biology are the ones who are trying to reformulate or extend the current theory.

You go on to say "I don't think she really understands anything about modern biology, only to discern controversy and scientific disputes that are somewhat divorced from reality"

I think to contend that there are no scientific disputes as you put it, is in itself "divorced from reality"
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John Kwok
08:55 AM on 04/27/2012
THEMAYAN, most of the people here do dispute that Natural Selection is important and their comments really display their ignorance of science and of the scientific method. What you describe with respect to Darwin is also inaccurate. Why?

Darwin gave us demonstrable proof that biological evolution does exist and is still occurring. Darwin gave us a mechanism, Natural Selection, that could explain at least some of biological evolution, which he realized operated via heredity. (Though he did not know anything about heredity; that would come later via genetics and population genetics.) Darwin conceived of Natural Selection from his reading of Malthus - so too Wallace - and was also inspired by Adam Smith's writing on economics (which inspired Darwin to conceive of his "economy of nature"). Darwin used artificial selection of domesticated plants and animals as an analogy to Natural Selection (which gave his version of it more scientific credence than Wallace's, since Wallace had no opportunity to do anything more but a "thought experiment" based on his knowledge of tropical biodiversity and his reading of Malthus).

Darwin was both a great field naturalist and a fine experimental scientist. Among his other achievments was his theory on the formation of atolls; sunken volcanic islands ringed by coral reefs, which is still seen as scientifically accurate by geologists, more than a century and a half after he proposed it.
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John Kwok
09:05 AM on 04/27/2012
It is a mistake that some biologists ignore the Modern ("Neo-Darwinian") Synthesis since it remains the best, most comprehensive, scientific statement with regards to our understanding of biological evolution and biology, especially since noted evolutionary geneticist Theodosius Dobzhansky, one of the "architects" of this theory observed that, "Nothing in Biology makes sense except in the light of evolution". (However, I agree with Allen MacNeill that we will need an "Extended Synthesis" of the kind proposed by Stephen Jay Gould and Massimo Pigliucci.) Moreover, many would contend that all of the recent developments in the biological sciences are due to the realization that biologists should heed Dobzhansky's observation. (An observation which I am sure even Shapiro recognizes.)

Much of science depends on inference ("educated guessing") and it would be best to say that I accept Natural Selection as an evolutionary mechanism as inferred by the data that has been collected for decades, including those of Darwin's Finches which have been studied for decades on the Galapagos Islands by the husband and wife team of evolutionary ecologists Peter and Rosemary Grant.

As for Suzan Mazur, I have met her and have discussed in person and via e-mail, evolutionary biology. Her understanding of it pales in comparison to other science writers whose work I am familiar with (including several I have met) such as Natalie Angier, Cornelia Dean, Faye Flam and especially, Carl Zimmer.
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James A. Shapiro
Author "Evolution: A View from the 21st Century
03:51 PM on 04/25/2012
John,

You ask "4) Explain how much you understand my point about the relevance of historical contingency."

I do not know a lot about historical contingency. SJ Gould was big on emphasizing this. But a respected evolutionist like Simon Conway Morris argues that evolutionary convergences are so common that there may not be as much contingency as Gould would like to believe.

I do know, and did mention in my book, that previous adaptations (such as a bilateral body plan) constrain the nature of future changes that will integrate successfully into the organismal phenotype. If this is what you mean about contingency, I agree. But that is very different from what Gould meant.
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John Kwok
10:57 AM on 04/26/2012
They're both right in stressing the importance of contingency and convergent evolution. I think Gould's example of "replaying the tape of evolution" is especially important, merely to refute claims by some, including Conway Morris and Miller, that the universe somehow anticipated us in some version of the Anthropic Principle.

As for myself, I realize now that I should have said "historical constraint" in lieu of "historical contingency", which is a point I have emphasized repeatedly in replies to your creationist fans. (Speaking of which, I think you need to emphasize the first sentence of your second paragraph merely as edification to those I am referrring to.)
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John Kwok
12:52 PM on 04/26/2012
I am puzzled by your observation that Conway Morris is a "respected evolutionist" as though you are implying that Gould isn't. (I might add that both Allen MacNeill and I would strongly beg to differ with such an assessment of Gould.)