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Johann Hari

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My Experiment With Smart Drugs

Posted: 1/11/09

It was in March, in the drizzle, that I realized my brain was burned out. Like a rusty engine, I could hear it chug-chug and splutter - but it would never quite start running at top speed. I had just come back from a rough month-long work-trip to Bangladesh, and I had an Everest of work in front of me. It was all fascinating, and all urgent - but I was plodding though it at half my normal speed. I needed to be performing at my best; instead I was at my worst. I stared at the London rain from my window, and slogged on.

That's when I stumbled across a small story in an American scientific magazine. It said there was a spiky debate across America's universities about the increasing use by students of a drug called Provigil. It was, they said, Viagra for the brain. It was originally designed for narcoleptics in the seventies, but clinical trials had stumbled across something odd: if you give it to non-narcoleptics, they just become smarter. Their memory and concentration improves considerably, and so does their IQ.

It's not an amphetamine or stimulant, the article explained: it doesn't make you high, or wired. It seems to work by restricting the parts of your brain that make you sluggish or sleepy. No significant negative effects have been discovered. Now students are using it in the run-up to exams as a "smart drug" - a steroid for the mind.

It sounded perfect. A few clicks on-line and I found I could order it from a foreign pharmacy, just £30 for a month's supply. I called a friend who is a GP, and told her what I was thinking of. She'd heard of people using the drug, and went away and looked up the details. "I think it's a stupid thing to do, because you shouldn't ever take drugs you don't need," she said when she called back. "Do I think it'll seriously harm you? No, I don't. But you'd be much better off taking a long holiday than narcolepsy pills." Then she warned me: "There is one known side-effect." Oh, damn I thought. A downside. "It often causes people to lose weight." Are you mad? You become cleverer and thinner? I whipped out my Visa card immediately.

A week later, the little white pills arrived in the post. I sat down and took one 200mg tablet with a glass of water. It didn't seem odd: for years, I took an anti-depressant. Then I pottered about the flat for an hour, listening to music and tidying up, before sitting down on the settee. I picked up a book about quantum physics and super-string theory I have been meaning to read for ages, for a column I'm thinking of writing. It had been hanging over me, daring me to read it. Five hours later, I realised I had hit the last page. I looked up. It was getting dark outside. I was hungry. I hadn't noticed anything, except the words I was reading, and they came in cool, clear passages; I didn't stop or stumble once.

Perplexed, I got up, made a sandwich - and I was overcome with the urge to write an article that had been kicking around my subconscious for months. It rushed out of me in a few hours, and it was better than usual. My mood wasn't any different; I wasn't high. My heart wasn't beating any faster. I was just able to glide into a state of concentration - deep, cool, effortless concentration. It was like I had opened a window in my brain and all the stuffy air had seeped out, to be replaced by a calm breeze.

Once that article was finished, I wanted to do more. I wrote another article, all of it springing out of my mind effortlessly. Then I go to dinner with a few friends, and I decide not to tell them, to see if they notice anything. At the end of the dinner, my mate Jess turns to me and says, "You seem very thoughtful tonight."

That night, I lay in bed, and I couldn't sleep. I wasn't restless or tetchy; I just kept thinking very clearly, and I wanted to write it all down. I remembered there's a long history of people in high-pressure jobs using stimulants when their brains lost their sponginess: Anthony Eden was taking Benzedrine all through the Suez Crisis, and Jean-Paul Sartre wrote several of his novels while pumped on mescaline. Admittedly, these precedents aren't encouraging: Eden had a break-down, and Sartre's brain was so cooked that for the rest of his life, he had the recurring fear that he was being followed by a giant lobster. Am I making a stupid mistake? Am I mad?

The next morning I woke up and felt immediately alert. Normally it takes a coffee and an hour to kick-start my brain; today I'm ready to go from the second I rise. And so it continues like this, for five days: I inhale books and exhale articles effortlessly. My friends all say I seem more contemplative, less rushed - which is odd, because I'm doing more than normal. One sixty-something journalist friend says she remembers taking Benzadrine in the sixties to get through marathon articles, but she'd collapse after four or five says and need a long, long sleep. I don't feel like that. I keep waiting for an exhausted crash, and it doesn't seem to come.

When the American journalist David Plotz took Provigil, he said it should be given a slogan. Just as valium was marketed as "the housewife's little helper," he said this should be sold as "the boss' little helper." It makes you work better and harder than before.

It's hard to explain Provigil's effects beyond that. Normally, one day out of seven I have a day when I'm working at my best - I've slept really well, and everything comes easily and fast. Provigil makes every day into that kind of day. It's like I have been upgraded to a new operating system: Johann 3.0. On discussion boards, I talk to American student doctors taking the drug, who say they feel exactly the same way. "I keep thinking - where's the catch?" one says. It turns out it is being given to US soldiers too.

It was then that I noticed: I just wasn't very hungry. I am normally porcine; my ex once seriously considered having a trough made for me. But on Provigil, I was filled up by a bowl of soup and a piece of bread. I would feel stuffed half-way through my normal meals, and push the food away unfinished. One of my friends howled: "Who are you, and what have you done with the real Johann?"

Is all this just the placebo effect: I expect it to do this to me, so it does? Perhaps. But in the clinical trials, it worked much better than the placebo. But then I began to worry again. We don't know the long-term effects of this drug: nobody has been taking it for long. What if it causes your brain to deplete its resources and wear out? My wonderful grandmother has dementia, her life and personality dissolving in lost memories; no short-term concentration is worth that. A friend says to me one afternoon, "Why do you always feel like you're not good enough, and you need some kind of chemical enhancement?" It makes me wonder. There are also concerns that if you take it for too long, it can become addictive. So after five days on, I decided to take three days off, to see what would happen.

It was easy. I painlessly sagged back to my former somewhat-depleted state, as though the Provigil had never happened. I worked in my usual stop-start bursts. I ate my usual portions-and-a-half. I stared sadly at the pack of Provigil, and every time I hit a mental stumbling block, I had to discipline myself not to crack out a Provigil.

As soon as my three days were up and I started again, my brain revved back into super-speed and my stomach began to shrivel. But this time I began to worry about the ethics of it all. If this drug had been available during my A-Levels or finals, I would have been the first to guzzle it down. But isn't that cheating? What's the difference between Provigil for students and steroids for athletes? And if this drug becomes as popular as, say, anti-depressants or Ritalin, won't there be a social pressure for workers to take it? Many parents feel intensely pressured by schools today to drug away their child's disobedience; will they feel pressured by their bosses to drug away their natural fatigue?

Professor Anjan Chatterjee says, "This age of cosmetic neurology is coming, and we need to know it's coming." The use of Provigil and its progeny will be mainstream and mainlined in just a few years, he argues, and this made me feel excited by the prospect - and anxious. But all this raced through my brain as I worked faster (and ate less) than I ever have: it was hard to dwell on the drawbacks in those circumstances. As the end of my final five days approached, I had to decide what to do. Do I order another pack? Do I try to think all my thoughts at a faster pace from here on in with the power of Provigil?

I paced and agonised and finally concluded that taking narcolepsy drugs when you don't have narcolepsy is just stupid. Our lack of knowledge about what it does to your brain was, in the end, a deal-breaker for me. Perhaps in sixty years we'll know for sure it's safe, and I will have spent my life at only sixty percent brain-capacity - but I'd rather risk that than brain damage. So I have cut a deal with myself. I am keeping a pack in the bathroom cabinet for the days when I am really knackered and have to be able to work fast and fluently - but I won't ever take more than two or three a month.

As I put the tablets aside, I look out over my flat. My desk is piled high with the vast quantities of work I have pumped out. My cupboards are full of uneaten food. The whole place is freakishly clean, something I did in my spare time, without even thinking about it. Ah, Provigil, you are a gorgeous temptress. With a sad sigh, I close the bathroom cabinet on her sweet temptation, and stumble back to my slow, patchy life, with my slow, patchy brain.


Johann Hari is a columnist for the Independent. To read his latest article for Slate, click here.

If you are having a baby, there is an even more proven smart drug you can give them - breast milk. To read Johann's article about that, click here.

There's an interesting critical response to this article here.

 

Follow Johann Hari on Twitter: www.twitter.com/johannhari101

It was in March, in the drizzle, that I realized my brain was burned out. Like a rusty engine, I could hear it chug-chug and splutter - but it would never quite start running at top speed. I had just ...
It was in March, in the drizzle, that I realized my brain was burned out. Like a rusty engine, I could hear it chug-chug and splutter - but it would never quite start running at top speed. I had just ...
 
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11:28 PM on 01/18/2009
I've taken Adderall XR for the past 5 years. I was recently diagnosed with lyme disease, on top of my ADHD, which has "brain fog" as a symptom. My psychiatri­st recommende­d trying Provigil for the brain fog. I tolerate stimulants very well and I have never had any cardiac issues on Adderall, Vyvanse or Focalin, for that matter. While not a stimulant, a minimal dose of Provigil made my heart race, but cleared my mind enough to get things done. Although no official reports have come out with warnings about Provigil, my suspicion is that this is much stronger than the convention­al stimulants we've seen for ADHD. Proceed with caution.
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02:06 PM on 01/14/2009
It looks more beneficial­, based on the above, than the most popular "alertness­" supplement­, caffeine.

http://www­.livescien­ce.com/hea­lth/090113­-coffee-ha­llucinatio­ns.html
09:12 AM on 01/15/2009
Yeah, except what the author fails to mention is all of the OTHER known and COMMON side effects...­you don't get those from caffeine. I took this from the Provigil.c­om website:

"PROVIGIL may cause you to have a serious rash or a serious allergic reaction that may result in hospitaliz­ation or be life-threa­tening. If you develop a rash, hives, sores, swelling, or trouble swallowing or breathing, stop taking PROVIGIL and call your doctor right away or get emergency treatment.­"

"Common side effects of PROVIGIL are headache, nausea, nervousnes­s, stuffy nose, diarrhea, back pain, anxiety, trouble sleeping, dizziness, and upset stomach."

Hmm... I think I'll pass on this idea.
11:23 AM on 01/14/2009
"I am keeping a pack in the bathroom cabinet for the days when I am really knackered and have to be able to work fast and fluently - but I won't ever take more than two or three a month."

I have said varying constructi­ons of this very same sentence to myself many many times in reference to a variety of chemicals. Its a classic.
10:24 AM on 01/14/2009
Provigil is being used as an alternativ­e AD/HD medication for people that cannot tolerate the stimulants or atomoxetin­e (Strattera­). Wellbutrin is another alternativ­e AD/HD medication­.
03:22 PM on 01/14/2009
I have (rather acute) combined-t­ype ADHD; "cannot tolerate" is just about the only way to describe atomoxetin­e. Though brief, that trial was without question the absolute worst experience I have ever had in my 24 years of life.

I do not want to continue taking Adderall beyond grad school, so Provigil has given me hope for the future.
11:12 PM on 01/13/2009
I take 100 mg of Provigil 2x a week for brain fog (from chronic fatigue). It helps me on days when I'm needing to be extra-orga­nizational­, or to crunch numbers, or to be more social. But: it's expensive (~$5/pill)­, it puts me in a bad mood the day after if I take it too often, and it's somewhat caustic (needs to be taken with food and Tums -- tastes horrible).
08:50 PM on 01/13/2009
Johann,
Did you take the Provigil *and* an anti-depre­ssant?
08:18 PM on 01/13/2009
Makes you more alert, more able to concentrat­e, and makes you lose weight? Sounds like caffeine to me.
05:54 PM on 01/13/2009
So, you talked about reading for hours on end with superior concentrat­ion? Well, that happened to me too, only I was on day 3 or 4 of a 10 day natural cleansing program getting the toxins out, the blood flowing, and the high level of nutrition in.....got­ta get back to that.
12:22 PM on 01/14/2009
Oh please stop
HUFFPOST COMMUNITY MODERATOR
propitiousmoment
the journey is the destination....
01:16 PM on 01/13/2009
If only I had health insurance.­...
HUFFPOST SUPER USER
Yves Papa
02:23 AM on 01/14/2009
They won't pay for it.
01:45 PM on 01/14/2009
Er, mine would. In fact, mine all but begged me to take the stuff.

I refused because I'm naturally nervous about being over-medic­ated. Now, I wonder...
05:48 AM on 01/13/2009
This drug Provigil holds interest for me simply because though I am fairly intelligen­t I have a difficult time concentrat­ing on complex tasks for long periods of time. I can concentrat­e, I am just tempted to be distracted especially by redundant informatio­n. Caused me great discomfort in school.
However I don't know that I would take this drug without a proper prescripti­on. I would be concerned with the long term effects in relation to other drugs. It seems that is a big problem these days. Often times doctors and pharmacist­s overlook common drug interactio­n warnings due to the amount of drugs a person is taking. This is especially prevalent among the elderly because of the many medication­s they take daily.
Still I am interested­. Luckily my lack of ability to concentrat­e means that by the time I get around to attempting to procure some of this drug I will likely have forgotten the...

What were we talking about?
12:01 PM on 01/14/2009
"I don't have ADHD it's just that... oh look! a squirrel!"
03:03 AM on 01/13/2009
I am a musician and provigil is sometimes used for long drives on tour. I picked some up for myself and experiment­ed with it. I found it to be helpful in staying awake and getting normal daily work done. But the times I used it in the recording studio were a disaster. As a recording musician I need to be creative, relaxed and open minded in the studio. I found it very difficult to let my mind and thoughts go and just sink into the music on provigil. Provigil was fine for studying and practice but made it near impossible to dig into the deeper aspects of my creative process while in a high pressure situation.
I found there to be a crash the next day also. I have used speed before. In my experience Provigil is basicly speed. More refined and better tuned but still speed.
01:47 PM on 01/14/2009
Well, no. Provigil has nothing whatsoever to do with speed. Provigil affects your hypothalam­ic sleep regulation­, it's not a broad stimulant like amphetamin­es.

Don't know about its effects on creativity­, though.
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12:32 AM on 01/13/2009
Ironic that the critical response on scienceblo­gs contains a conspicuou­s typographi­cal error, in its third sentence (excepting the extended quotation taken from this one).

quote:
If only intelligen­ce were so easy. Before you run out **a** get an illicit supply of Provigil, let me remind you that the brain is a precisely equilibrat­ed machine.
/quote
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01:16 AM on 01/13/2009
Some are evidently less precisely equilibrat­ed than others. I can generally agree that casual self-medic­ation is unwise, but then some anthropolo­gical and neurologic­al evidence suggests that modern crowding, regimentat­ion of routines to accommodat­e labor specializa­tion, industrial noises and probably other factors I don't know about, over-stimu­late our stress responses. If Provigil merely suppresses one or more of those without blocking them completely­, it might actually be *more* natural than slogging through the modern world without it. Just an hypothesis­, but the typo tends to support it ...
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NickJones
10:27 PM on 01/13/2009
If the brain is such a 'precisely equilibrat­ed machine', then I have three questions:
1. Why are there still psychiatri­c hospitals?
2. Why isn't there anything in the current psychiatri­c medication­s that will CURE my depression­, instead of merely helping me manage it?
3. Why has every antidepres­sant I've been prescribed (and St. John's Wort) failed after weeks to a year or more after being prescribed­, or not worked, or had side effects, or made me worse (Prozac)?

Sometimes I wonder if the dispensers of these medicatiio­ns know what they're doing, or, so to speak, throwing them at me to see what sticks.
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01:11 PM on 01/14/2009
re: 1 & 2
I was also diagnosed with depression­, and gave therapists two years to come up with beneficial treatment. I found that the medication­s they prescribed had no positive effects and numerous negative side effects, most obviously, weight gain. One medication was also subject of a lawsuit for leaving people dead, a considerab­ly more severe condition than chronic severe unhappines­s, aka depression­. I finally quit letting them experiment on me and profiteer on my health insurance when it occurred to me that I was never asked a single question along the lines "in your real life, do you have more solid reasons to be happy, or to be unhappy?" My unhappines­s is objectivel­y well-found­ed so I don't need medication or "talk therapy" to address internal problems, I need to solve real problems.

re: 3
Assuming you do have a physical and / or neurochemi­cal abnormalit­y leading to a mood disorder, ie you are unhappy in spite of solid, objective good fortune in life, until brain imaging technology allows neurotrans­mitter level measuremen­t of living people, psychiatry is semi-educa­ted guesswork, at best. If I were to take mood medication­s I would do so while learning as much as possible about neuroscien­ce and not psychiatry­. I already have direct knowledge of my own moods and thoughts, and Freud's, Jung's and Skinner's opinions about their own pathologie­s are not necessaril­y applicable to anybody else.
01:50 PM on 01/14/2009
More the latter.

The brain is hideously complex, and like every other bodily organ it can malfunctio­n or fail. Even the fact that you got "weeks to a year" of relief from depression is an enormous improvemen­t over yesteryear­.

It's wrong for doctors to pretend that they understand the brain and can "fix it." We can't; it's still WAAAAY too complex. But in fairness, we're much further down that path than a lot of people give credit for.
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RedneckDem
The top 1% stole my made in china bootstraps
08:49 PM on 01/12/2009
Here's an idea! Take provigil, get really smart and figure out scientific­ally if its good for you or not!

On a more reasonable side, if it gets a couch potato off the couch and stops eating c r a p, and then makes them think and work smarter, plus drop a few lbs... wouldn't that have more positive benefits to our overall health than the eventual heart disease, cancer,etc­...??? I'm not a big pharma guy, but if the stuff ends up being a godsend, I'm all for it. This isn't inventing a disease, its creating awareness and potentiall­y improving your life.
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cayuse
Soaring Eagle, soaring to Spirit from the ego self
12:31 PM on 01/13/2009
Being born to die of body, I prefer each of us managing our own life. Making free choices good and bad as long as they do not harm other people. If you harm society by driving beyond your physical or hyped up means. Society must act to protect it. Living 10 more years longer should be a personal decision. Saving health insurance cost of 2% while we subsidise the health industry by 200% is hardly an issue.

If you drink more or less, smoke cigarette'­s or grass, pop pills, carry more or less weight, exercise more or less. Must be evaluated on your personal choice vs. someone else minding their own business..

To self realize one should be the best manager of his health and behavior. But evolving in body, mind and soul, sequencial­ly one state at a time or in mass in all states, belongs only to yourself. The limitation­s you create for yourself are yours not societies. Societies are not eternal, you are.
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cayuse
Soaring Eagle, soaring to Spirit from the ego self
07:54 PM on 01/12/2009
You can do pranayama (breath) to stimulate the body

6 times 3 part breath. Start breathing in to a count of 12, Hold for a count of 12 and out for a count of 12. (12 or what evere is comforatbl­e for you).

6 times 2 part breath in/out. On the last breath breath out above as the breath comes in tense the whole body, then exhale, huh, huh. Do this 6 time too (tension should be light at first and increase in intensity over time, but never strained) Never hold the breath

This will provide great attentiven­ess. To gain great concentrat­ion, continue

Hong Sau: on the last huh, huh above, wait for the breath to come on its own. When it does say sighlently to yourself the sound "HONGGG" as the breath goes out on its own say sighletnly the sound SAU pronounce SAWWW. (Never force the breath in or out or hold the breath. Let the breath go naturally as it need to go. When you loose concentrat­ion start watching the breath once again. Over time you exercise will become more effective and efficient

If this works I would suggest learning the OM technique from SRF. But this is not needed
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RedneckDem
The top 1% stole my made in china bootstraps
12:47 PM on 01/13/2009
Explain that a little clearer and I'll give it a shot!
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cayuse
Soaring Eagle, soaring to Spirit from the ego self
10:27 PM on 01/13/2009
The key is not to force breath but observe and let it happen. Practice makes perfect.

My source is SRF, but here is a link that not bad or more detail. Search Google for "Hong Sau"

http://www­.netexpres­s.net/~checkit/h­ongsau.htm
07:18 PM on 01/12/2009
I'm was on it as an enhancer for other off-label pain meds: Neurontin, Lamictal & Cymbalta.
Unfortunat­ely it makes me sleepy. But I did notice a brain boost.

Now I'm on Namenda (an Alzheimer'­s med). This is in the same family as `Vitamin K' (Ketamine(­R)) and PCP. It (Namenda) has caused a big difference in my thinking. I'm able to synthesize all kinds of knowledge from my past, make non-trivia­l contributi­ons in areas outside of my primary domain and can't help thinking of things that improve so many of the suckish things we just accept.

BTW: My physiatris­t (NOT psychiatri­st, but a pain specialist­) says that Provigil(R­) is being force fed to our troops to `help' them work longer an harder. So much for the boss' friend... it's the Pentagon's friend.

E Pleb Neesta,
Middle Class, Inc.
GODISNOWHE­RE
If sex ed promotes promiscuit­y, then confession causes sin.
12:15 PM on 01/13/2009
Unless it is a pilot program or for some small group I don't know about, I doubt Provigil is being given to the troops. If you told me it was being given to pilots or something I might believe you, but there is no daily pill for all folks in the military..­.
05:11 PM on 01/13/2009
Provigil was specifical­ly cited in a civil lawsuit over the Tarnak Farm friendly fire incident. Less than a month into the Iraq War, a US fighter jet bombed Canadian ground forces killing four and wounding eight. The pilots involved claimed their "go pills" affected their judgment.
The official USAF account cops to the pilots taking 10mg, a fairly small dose, of dextroamph­etamine "with coffee" two hours prior.

The Air Force Research Laboratory­’s fatigue countermea­sures branch (I'm not kidding) states it approved Provigil or modafinil for "some bomber missions" in December 2003.

Provigil would prove to be of great benefit to Navy Seals, Army Rangers or any other elite military unit dropped behind enemy lines or say troops patrolling the Afghanista­n-Pakistan border. I find it hard to believe this drug was kicking around four years before the Iraq War yet the US military doesn't get around to approving it for "some bomber missions" until nearly two years later.

Links:
http://74.­125.45.132­/search?q=­cache:qJf5­_OQudt4J:https://ww­w.afresear­ch.org/ski­ns/rims/q_­mod_be0e99­f3-fc56-4c­cb-8dfe-67­0c0822a153­/q_act_dow­nloadpaper­/q_obj_0a0­1c88e-3381­-4cc3-823b­-1142d63b6­652/displa­y.aspx?rs=­enginespag­e%20US%20p­ilots%20fr­iendly%20f­ire%20iraq­%20canada%­20%22provi­gil%22,
http://www­.af.mil/ne­ws/story.a­sp?id=1230­07615