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John J. Mariani, M.D.

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Addiction: Bad Behavior or Biologically-Based Disorder?

Posted: 09/10/2012 9:12 am

Addictive disorders occupy a unique niche in our society and culture. The consequences of substance use disorders are widely known, yet ignorance of the biological basis of these disorders is common. Most people know family or friends with alcohol or drug problems, and the media is full of reports of well-known individuals. When viewed superficially, individuals with substance use problems often appear to be behaving illogically and making self-defeating choices, so it is easy to assume that the primary problem is a moral failing or a lack of willpower. This viewpoint leads to our society supporting punitive approaches for managing alcohol and drug addiction, rather than using a public health framework.

The risk of developing an addiction to alcohol or drugs is based on genetic, developmental, and environmental factors. Recent studies estimate that the proportion of risk in developing a substance use disorder due to genetic factors is at least 50 percent. These data suggest that behavioral disorders where the appearance of "choice" seems central are still highly determined by biology. Most people in the United States sample alcohol and other addictive substances at some point during their lifetime. What separates the people who go on to develop addiction from those who don't are a series of variables that were not in their control.

This is not to diminish the role of personal responsibility in managing addictive disorders. As with any health problem, optimal outcomes can only be achieved if the afflicted individual meaningfully participates in their treatment. For a diabetic, measuring blood sugar, taking prescribed medication, and following dietary recommendations is necessary to achieve the best outcomes. Likewise, an individual with a substance use disorder needs to follow treatment recommendations in order to live the happiest, healthiest life possible.

There are a wide variety of treatment options available to treat substance use disorders. Evidence-based behavioral therapies and medication treatments have been shown to improve the health of individuals with alcohol and drug addiction. Evidence-based behavioral treatments aim to increase motivation and develop skills for abstaining from substance use and managing distressing emotional states. Medication treatments tend to be more specifically directed at a particular substance. Effective medications are available for treating nicotine, alcohol, and opioid dependence. Research is ongoing to develop treatments for cocaine, methamphetamine, and cannabis dependence. In addition, other psychiatric disorders (e.g., depression, ADHD, anxiety disorders) frequently co-occur with addictive disorders. These co-occurring disorders need to be simultaneously treated along with the substance use problem in order to obtain the best possible outcomes.

There is a lot of controversy regarding "harm reduction" as a treatment goal. Examples of harm reduction include clean needle exchange, safe injection facilities, and treatments that are oriented toward reduction in substance use ("moderation"). Some authorities argue that anything short of complete abstinence from substance use is unsatisfactory, and in some cases harm reduction interventions promote drug use. My opinion is that this is a moralistic approach unsuitable for managing health care problems. The health consequences of alcohol and drug addiction are generally proportional to the amount of substance used. Reductions in substance use, without achieving abstinence, can result in improvements in physical health. Complete abstinence is clearly the optimal outcome for most individuals with substance use disorders. However, treatment that reduces harm and improves health can be valuable even when abstinence is not achieved. Even an intervention, such as needle exchange, that does not target drug use directly, can be extremely beneficial by reducing infectious disease risk and by providing a mechanism for engagement in treatment in general.

The hope is that is as science progresses, and as discoveries regarding the biological basis of addictive disorders, as well as the availability of effective treatment, becomes more widely known, the stigmatization and marginalization that individuals with addiction face will be reduced, and access to care will be improved.

Tune in to Healthy Living's Twitter chat with Dr. Mariani and HuffPost Healthy Living mental health editor, Dr. Lloyd Sederer, today at 1 p.m. ET, with the hashtag #livehealthy.

For more on addiction and recovery, click here.

 
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Addictive disorders occupy a unique niche in our society and culture. The consequences of substance use disorders are widely known, yet ignorance of the biological basis of these disorders is common. ...
Addictive disorders occupy a unique niche in our society and culture. The consequences of substance use disorders are widely known, yet ignorance of the biological basis of these disorders is common. ...
 
 
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03:20 PM on 09/11/2012
Having lived with people who were addicted to rx and alcohol I made it a point to get informed about the whys etc. One physician study indicated that when an addictive person takes a drink or uses a drug they feel much more intensity from it.They don't just enjoy it, it is absolutely fabulous at least initially.
This is a brain chemical imbalance at work. So, when you feel powerless and have no coping skills for whatever reason, you resort again and again to the things that make you feel, not just a little buzzed, but FABULOUS. Another credible study seems to indicate that the triggers are "powerlessness" in whatever situation you want to apply it and this would be those things learned very early in childhood. My own additional theory is they should also explore the adrenal gland's role in stimulating the need for risky behaviors as well.
05:30 AM on 09/11/2012
What a person puts in their mouth or body for effect, is a choice choosen by them. Just like they made the decision to, they can make the decision not to. They made the decision. No way around that.
09:45 AM on 09/11/2012
First of all, this statement assumes that when a person puts something in their body they fully understand every implication of that choice. With drugs, and the early onset of use for many, that is a patently false statement. Saying that a 14 year old is fully aware of the choice they are making when trying some drug is making a slew of assumptions that are in no way supported.
Secondly, is the point of the comment to say that no one else can intervene to help? Again, that would fly in the face of quite a bit of research showing that even when people have difficulty quitting on their own, they can be helped.
04:26 PM on 09/11/2012
I really wasn't including children. I believe  every one has preferences. Some preferences have undesirable consequences. If each individual agrees with the consequence, no matter how many people may have warned of the hazards of certain activities, the individual as chose to accept the outcome. Also being aware of the outcome, if they find comfort in it taht outweighs the consequences then that is what they will chose to do. Only when one makes up their own mind will they do what ever decision they have made for themselves regardless of the outcome. Adults are fully aware of the outcome or reaction to the action they choose. If that is what they want, that is what they will do. I respect your response and have read it closely. This is only how I see it for it varies from mind to mind how a thing is perceieved. Taking responsiblitlity for my actions is choice.
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Portann
Lola: Punish the deed not the breed
03:27 AM on 09/11/2012
Why does it have to be either or? How about both? Ultimately, it doesn't matter, the treatment is the same. People may not have control over genetics, or the environment that they were raised in that may also attribute to the behavioral imprinting that occurs between adults and children. I know people born from parents with addictions that never manifest in them as adults. And, I know people who were not born of parents afflicted with addiction that later became addicted to substances. People may not be responsible for their disease or the factors beyond their control that may have contributed to it, but they are responsible for their recovery and all that goes into sustaining that.
12:32 AM on 09/16/2012
You are right on target!
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LemmonHerk
02:46 AM on 09/11/2012
I don't think it's an either-or, all-or-nothing, black-and-white thing -- I think it's a case of willing participation in something that activates some sort of "addictive behavior gene". I'll bet if they ever developed a test for it, they'd find the gene in some practicing Mormons, Adventists, and Muslims, too -- all of whom don't drink -- but they don't even know it, much less have a problem, because they don't indulge in the risky behavior. I take an SSRI Rx for an anxiety disorder (mild depression with O.C.D.), and I noticed that, without making any conscious effort, I drink AND eat a lot less than I used to, and have lost about 55 lbs. Apparently, I was subconsciously self-medicating for stress, and, since alcoholism runs in my family, I can't help but suspect the right Rx would've helped them, too. I can still drink, but I just don't think to nearly so often, nor as much, and I don't get the "pity-party munchies", either.
09:48 AM on 09/11/2012
As long as we don't think that there is actually a single gene, but instead a collection of genes that contribute, I think you are right on. There a a slew of factors, but biology is a big one among them for a significant portion of addicts.
02:33 AM on 09/11/2012
Addiction is caused by nasty, immature, controlling, threatening, using, conning and abusive people or "family members" in your life!

And if you don't get them out of your life permanently, they will drive you crazy or to death.
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Jerry Bourbon
12:00 AM on 09/11/2012
Addiction is neither. It is a personal weakness, nothing else.
12:46 AM on 09/11/2012
It's very apparent you have no idea what you're talking about.
12:47 AM on 09/11/2012
yeah, like eyesight LoL
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LeftRightCenter
Imagine a world w/no hypothetical situations...
11:35 PM on 09/10/2012
i want 2 meet the human who has NO ADDICTION
04:13 AM on 09/11/2012
Let me introduce myself...as soon as I finish this pizza!
09:51 AM on 09/11/2012
Most people in the world have no addiction... What makes you think otherwise? You believe that most people in the world live with an unhealthy obsessive-compulsive tendency to do things that are bad for them without being able to stop? Sounds like a bleak worldview...
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LeftRightCenter
Imagine a world w/no hypothetical situations...
10:56 PM on 09/11/2012
yes, i do
10:42 PM on 09/10/2012
Sadly, some people find many addictive ways, legal and otherwise, this, to avoid realizing the emotional need for others.

I think psychiatric drugs have become widely used due to denying this need, and our need to be needed by others.

I think its impossible to, completely, fill an inward emptiness without recognizing this.

It's like the song: "People who need people, are the luckiest people in the world."

Its my understanding there's, still, no medical test that can actually prove an addiction or a mental illness exist.
05:57 PM on 09/23/2012
You don't need a test to know if someone is an addict.
08:28 PM on 09/23/2012
Yes, I agree, I don't need a medical test, because none exists.

Rather than labeling a person an 'addict,' I prefer instead trying to "be with them" on an emotional level.

I think "bottled up emotions" is a primary cause of addictions.

What do you think?
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deputy85
Rightwing,retired n doing great
06:58 PM on 09/10/2012
Addiction is a complete lack of disipline a it isnt gonna hurt me, im to strong for that, attitude by weak minded people,then they have the oh poor me it was hereditary and not my fault excuse to lean on and seek sympathy,, my dad died in his own drunken vomit, but neither my brother or i are drunks so did we just by some miracle dodge the bullet? no we saw what it did and avoided it,,
11:57 PM on 09/10/2012
Hey, deputy85, you obviously don't know what you are talking about. There are many alcoholics that are extremely disciplined!!!! Look at the the cops, firemen, nurses, doctors, and members of the military that are alcoholic. I speak from experience. I am a retired military policeman and am a recovered alcoholic. I suggest that you attend some Alanon meetings and also read the book "Adult children of Alcoholics" you might learn something about yourself.
07:58 AM on 09/24/2012
I agree with the other poster. Attend Alanon, and perhaps you will come to understand this horrible disease.
05:12 PM on 09/10/2012
An addiction to some fairy tale is the worst addiction of all.
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Jerry Bourbon
12:01 AM on 09/11/2012
So don't be addicted to it.

Simple, really.
12:53 AM on 09/11/2012
wow, and this whole time everybody with addictions were just being difficult, right? if only we had just taken ur advice. just dont be addicted! well now everything is better. how could i have not seen so simple it is. . (ps: thats all sarcasm, jerry) yeah, just dont be addicted! LoL
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cds12765
I'm not crazy, my mother had me tested.
04:27 AM on 09/11/2012
The worst fairy tale of all is your belief in that delusion oh queen of de nile.
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x jmp
03:20 PM on 09/10/2012
We need research into no-cost and low-cost approaches. Many people who have suffered from substance abuse for years simply don't have the money for procedures and medications or in-patient rehab, much less multiple stints in rehab.
When there's underlying trauma, therapy can help, but what if the abusers were the very people the addict/alcoholic is dependent on practically and financially? That has to be addressed--the need for childcare, transportation to and from meetings, and income while the newly sober person is seeking a job can all be issues that jeopardize sobriety. And if it's your abusive parents providing all that...it's a problem.
Also, let's not overlook a mind-body-spirit approach: Higher power, cognitive behavioral therapy, somatic therapies, antidepressants or better yet more natural interventions such as supplements and nutritional support that prevents cravings and mood swings, acupuncture, yoga and other mindfulness-based practices...there's a lot besides prescription drugs that can help.
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Jes from Kemah
Just Caught in the Middle
07:35 PM on 09/10/2012
I agree. I work in the Medical field and these treatments are expensive and out of the range for most.
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cds12765
I'm not crazy, my mother had me tested.
04:28 AM on 09/11/2012
So do I for some of these people to claim that addiction/substance abuse isn't biological but a lack of will power just astounds me.
09:53 AM on 09/11/2012
I work in a relatively cheap outpatient clinic but I agree that there is a need for more capacity in the low/no cost treatment world. But then govt just wants to cut all money for social services so maybe not in our lifetime.
01:14 PM on 09/10/2012
"A common cause of addictions is spiritual emptiness coupled with inability to face reality. This results in the need to take external substances to boost energy levels and to cope with stress. We need to generate energy from inside instead of relying on external addictions. We must fill the emptiness from the inside first."--Yogi Bhajan
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FatBoy1953
I'm not the same, I never was.
12:20 PM on 09/10/2012
I put myself in treatment for alcohol and drug abuse. Use of alcohol and drugs does not indicate a disorder; it is the abuse of alcohol and drugs. It is when the acquisition and consumption of those substances is the driving force of your life.

It has been my experience that my problem is psycologically based. I had to address people, places and things that triggered my abusive behavior. I had to realign my thinking. And in doing so, I have found the serenity to accept the things I cannot change; the courage to change the things I can; and the wisdom to know the difference.
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larandall23
My micro-bio is empty for a reason
07:39 PM on 09/10/2012
I congratulate you and wish you well on the journey you will have to continue for the rest of your life. You and my sister are on the same page. She is doing well and I hope that you are too.
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ckdogs
Veritas
10:32 AM on 09/10/2012
Agree that many addictive disorders have a basis in genetics. Alcoholism runs in families, as does obesity. Finding the "cure" will be based on science and medicine rather than incarceration and punishment.
04:26 PM on 09/11/2012
I don't necessarily agree that it's genetics, but more of a learned behavior. Children become the products of their environments. They learn the behavior by being in the environment that the addict is in and watches them binge, thus, they learn it firsthand by a loved one or someone who is very close to them. This makes them think it is alright to be that way.
08:01 AM on 09/24/2012
It can be both. I'm a recovering alcoholic, and there was no drinking in my family. My parents were perfect role models in that realm.