Every time Obama says change everyone has to switch seats and drink the other person's drink of choice.
Every time John McCain tries to associate Barack Obama with an unsavory character, take a sip of your dirty martini.
Every time someone says bailout you have to finish your drink and pour another.
Every time John McCain says "my friends", spit out your drink and shout "I am not your friend" at the television.
Every time "evil", "evil doers", or anything with evil is mentioned, drink a sip of French red wine.
Every time Barack Obama ties John McCain to George W. Bush, drink a sloe gin fizz and wish for better days.
Every time John McCain displays how hopelessly out of touch he is, drink an old bastard.
When Georgia is mentioned, drink a fuzzy navel.
If anyone mentions a golden parachute, pound some goldschlager.
When NATO membership is mentioned, clink glasses with everyone around you and attack anyone who refuses to clink.
Regardless of what either candidate says, at the end of the debate, drink something that must be lit on fire first then hit yourself in the face with a shovel.
Leave your own suggestions as comments, and have fun tonight!