Depression is one version of hell on earth, and Americans have a lot of it. A recent international study of 18 countries found America near the top, with 19.2 percent of the population having experienced depression -- only France, at 21 percent, ranked higher. With our tottering health care system and vigorous arguments that antidepressants are useless, what are people to do?
Lots. Recognize that a stalled body and a stalled economy have much in common. They can degenerate or reinvent and regenerate themselves to survive and thrive. Depression is a systemic, whole body illness -- its causes are multiple, its manifestions endless and its treatment multi-faceted. As Jonathan Himmelhoch and others have argued, depression represents an overall failure of the human body to adapt.
It's time to adapt a new way of looking at the human body -- one that aids us to heal ourselves.
When you're depressed you can't think, and you can't sleep. Your IQ drops, you're tired in your bones and you become convinced this horror will never leave -- and nothing will make it better. No wonder depressives were burned as witches in 17th century England and New England; the transformation of the person is so total only devils could have done the work.
And the causes? More than you can name.
People with pancreatic cancer can become severely depressed months or years before the tumor is found. Hypothyroidism can lead to depression, as can adrenal insufficiency, strokes, heart attacks, rheumatoid arthritis, child abuse, job loss, loss of a loved one, a football player who breaks his leg. The medical causes can fill a textbook, and the social ones can and do break your heart.
It's no wonder the World Health Organization labels depression as the No. 2 cause of worldwide disability by 2020. But the medical problems alone are legion, as a recent study of depression and strokes demonstrates. From a medical cost standpoint alone, costs are a doubling of mortality and illness in a younger group right in the prime of life. Beyond the increased rates of coronary artery disease, diabetes and osteoporosis, there are changes in systemic inflammation, overall immune response, increased visceral fat, ineffective fibrinolysis. The lack of adaptation inherent in depression causes more than the loss of jobs and the frequent end of marriages; it makes people physically sick just as they lose their hope to get well.
Systemic Treatment and Prevention
Most of your body is gone in four weeks. Take out bones, teeth, cytoskeletal proteins, and you are newly new -- even when depressed. You want to use that capacity for regeneration to get better. And there are more ways to get well than people generally know:
Social support is one of the most effective actions people can do for those who are depressed -- particularly those who think they'll never get better. And the literature that social support robustly prevents getting depressed goes back to Berkman and Syme and the 1970s. Keep your friends close.
Conventionally Unconventional Treatments
Many depressed people can't do anything to help themselves. They can't get out of bed. They have no initiative, no motivation, no energy. So people turn to conventional treatment:
Out of this debate it's useful to recognize: a). Many of the older antidepressants (tricyclics, MAOIs) work as well or better than the newer, more popular, GP dispensed SSRIs; b). Antidepressants are quite good at preventing depression and treating concomitant anxiety; c). Lots of people get depressed because of medical conditions, where antidepressants tend to be effective; d). Placebos have a big place in conventional medicine -- they help people heal themselves.
Depression and Regeneration
The human body learns or it dies. If our immune system can't learn to adjust to the innumerable mutations of the 100 trillion critters living inside us, we're toast. Without effective immunity, the bacteria on a single human hand can wipe out all humanity.
Depression represents a global failure of adaptation. The body does not regenerate the way healthy bodies do. But there are many ways to treat this scourge, and to prevent it. And many of these treatments -- whether they're bright light boxes, physical activity or cognitive-behavioral techniques that allow the world to be seen in terms of solutions rather than problems -- also promote systemic regeneration.
So when you're depressed, remember this: almost everybody gets better. And there are many ways -- more than we imagine today -- to get better. Some involve drugs and therapists, but many engage friends, family, nature, the community, sunlight and walking. And by regenerating people out from the abyss, we can also regenerate their work, their creativity, their homes, families and communities.
There's a lot more to treating depression than drugs.
Follow Matthew Edlund, M.D. on Twitter: www.twitter.com/therestdoctor