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Log Cabin Republicans aren't the only ones Frank offended with this insensitive comparison. "Uncle Tom" is a racially loaded slavery reference, and his decision to use it here was entirely inappropriate.
The context in which he uses the word suggests not only that Savage meant to demean and degrade, but that he meant to demean and degrade by comparing GOProud to a particular set of gay men (bottoms) and all those who enjoy receiving penetrative sex.
Besides the fact that he was raised in a devoutly Catholic home and is the country's leading gay activist, who is Dan Savage to say anything at all about the ages-old Christian condemnation of gay people?