When a fatal disease like ALS comes into your life you have two choices: accept the diagnosis and wait to die or use everything you've got to fight. When Kevin Gosnell was diagnosed, he chose to fight. Kevin immediately put his business acumen and CEO leadership skills to work to come up with an idea - ALS ONE.
Research is by definition exploratory, which means that (a) we do not know what will work and (b) we need to explore many paths, we need a lot of diversity of research directions in the scientific community. So I can only tell you about my current gut feelings and visions of where I see important challenges and opportunities that appeal to my personal aesthetics and instincts.
The skills gap is the popular term used to describe the perceived disparity between those who are unemployed looking for a job and companies with jobs looking for employees. More specifically, it is the mismatch between the needs of employers for skilled talent and the unavailability of those specific skills within the workforce.