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Paul Armentano

Paul Armentano

Posted: February 16, 2011 10:09 AM

It was nearly two years ago that the Obama White House issued its "Scientific Integrity" memorandum stating, "Science and the scientific process must inform and guide decisions of my Administration."

Those of us involved in marijuana law reform welcomed the memo -- which came just months after the American Medical Association called for "facilitating ... clinical research and [the] development of cannabinoid-based medicines" -- and we hoped that it would stimulate the commencement of long-overdue human studies into the safety and efficacy of medical cannabis.

Those hopes were snuffed, however, when a representative from the U.S. National Institute on Drug Abuse (NIDA), the agency that oversees 85 percent of the world's research on controlled substances, reaffirmed its longstanding "no medi-pot" policy to The New York Times. "As the National Institute on Drug Abuse, our focus is primarily on the negative consequences of marijuana use," a spokesperson told the paper in 2010. "We generally do not fund research focused on the potential beneficial medical effects of marijuana."

A review of the U.S. National Institute of Health website clinicaltrials.gov shows that NIDA's kibosh on medical marijuana trials continues unabated. Though an online search of ongoing FDA-approved clinical trials using the keyword "cannabinoids" (the active components in marijuana) yielded me 65 worldwide hits, only six involved subjects's use of actual cannabis. (The others involved the use of synthetic cannabinoid agonists like dronabinol or nabilone, the commercially marketed marijuana extract Sativex, or the cannabinoid receptor blocking agent Rimonabant).

Of the six, two of the studies have already been completed: "Opioid and Cannabinoid Pharmacokinetic Interactions" and "Vaporization as a Smokeless Cannabis Delivery System," both of which were spearheaded by researchers (primarily Dr. Donald Abrams) at the University of California at San Francisco.

The four remaining studies are still in the "recruitment" phase. Of these, only two pertain to the potential medical use of cannabis: "Cannabis for Spasticity of Multiple Sclerosis," which is taking place at the University of California at Davis and is likely the final clinical trial associated with the soon-to-be-defunct and defunded California Center for Medicinal Cannabis Research and "Cannabis for Inflammatory Bowel Disease," led by researchers at the Meir Medical Center in Israel.

Of the remaining studies, one focuses on the detection of cannabinoids and their metabolites on drug screens, while the other, entitled "Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks," seeks to establish pot-related harms, hypothesizing that subjects "demonstrate poorer decision-making abilities and increased risk-taking behaviors" after smoking marijuana.

So much for the AMA's demand for clinical cannabis research.

By contrast, preclinical (animal) trials assessing the therapeutic efficacy of cannabinoids are occurring at a record pace. A keyword search on the search engine PubMed using the term "cannabinoids" yielded over 1,300 published papers in 2008, some 1,700 papers in 2009 and another 1,200 published last year.

While many of these studies highlight the ability of cannabinoids to manage a wide range of symptoms, even more intriguing are the results indicating the potential of cannabinoid intervention to halt the development of serious diseases, such as cancer, diabetes, Lou Gehrig's disease and multiple sclerosis. Nevertheless, without abrupt changes at the highest levels of government -- changes that do not appear to be forthcoming despite this administration's public demand for "scientific integrity" -- scientists will indefinitely lack the human follow-up data necessary to adequately answer societal questions regarding cannabis safety, efficacy and proper dosage.

"Change we can believe in?" Not when it comes to studying pot.

 
 
 
It was nearly two years ago that the Obama White House issued its "Scientific Integrity" memorandum stating, "Science and the scientific process must inform and guide decisions of my Administration." ...
It was nearly two years ago that the Obama White House issued its "Scientific Integrity" memorandum stating, "Science and the scientific process must inform and guide decisions of my Administration." ...
 
 
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08:25 PM on 02/20/2011
hummm
08:40 AM on 02/19/2011
Society would undergo dramatic changes, people would permanently change for the better as others would change for the worse. Some of us wouldn't know how to accept the thought of it being legal, and being available to the masses. The moral standard of some would be destroyed, religion would become more annoying. It might pose a threat to our youth in the sense that education may become more narrow, and less diverse in social development. Truthfully there is no reason for why it should remain illegal, but even if the day comes when marijuana is finally legalized there will be some sort of calamity or invalid purpose for it to become illegal once more... or something like along those lines.

Our government is scandalous, but until there is some sort of revolution we're pretty much screwed.
03:12 AM on 02/19/2011
The Feds quieting anything good about marijuana and preventing unbiased research is nothing new!

http://www.jackherer.com/thebook/chapter-five/
"After the 1938-1944 New York City ”LaGuardia Marijuana Report” refuted his argument, by reporting that marijuana caused no violence at all and citing other positive results, Harry J. Anslinger, in public tirade after tirade, denounced Mayor Fiorello LaGuardia, the New York Academy of Medicine and the doctors who researched the report.

Anslinger proclaimed that these doctors would never again do marijuana experiments or research without his personal permission, or be sent to jail!"

THE LAWS PROHIBITING MARIJUANA ARE NOT A RESULT OF ANY HARM FROM MARIJUANA. THEY ARE THE RESULT OF LIES, GREED and racism. Read the well documented proof of that and a lot more marijuana TRUTH in these two articles: “MARIJUANA AND HEMP THE UNTOLD STORY, Thomas J. Bouril” and “WHY IS MARIJUANA ILLEGAL, Pete Guither”, click the links to those articles on this webpage:
Internet Explorer web browser: http://jsknow.angelfire.com/home
All Other Browsers: http://jsknow.angelfire.com/index.html
08:39 AM on 02/18/2011
-Liberal- mantra is anything that feels good must be OK and because when we want something we should have it no matter what the consequences? Lack of -Discipline- is the root cause of why we are no longer a -Super Power- and we can blame everybody but ourselves because we have become fat and lazy and morally corrupt and all the pontification in the world will not change anything?
11:30 AM on 02/18/2011
What does that have to do with the efficacy of this harmless plant to treat disease and ease pain? Not to mention the thousands of other uses such as fuel, paper, textiles, etc?
01:45 PM on 02/18/2011
Hey, why don't you go relax and have a few beers. Save the weed for those who appreciate it. As long as some intoxicants are allowed and others are not, it's all B$, as is your comment.
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camanokat
Outta this world
06:40 PM on 02/17/2011
my mistake...here is the correct address:

www.GreenPassion.org

have fun!
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camanokat
Outta this world
06:39 PM on 02/17/2011
You can find a 420 page report on the benefits of cannabis here:

www.GreenPassion,org

and many user testimonials about cannabis as well.
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HUFFPOST SUPER USER
No death panels
There's no man with a trumpet. Only me.
10:40 PM on 02/16/2011
Maybe it's because most of the groups that argue for "medical marijuana" do it just because they can't get it legalized.
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invient
The invisible hand just gave us the finger!
10:58 PM on 02/16/2011
We'll see if it can be legalized in Colorado once it comes to a vote... I believe it will.

Most of those groups see it as an atrocity to be illegal as a medicine... they see it as an abuse of power for it to be illegal.

Government should not be used to impose a moral agenda... drug use is a moral agenda, just like abortion is.... it is arguably better to expand personal rights, rather than shrink them.
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HUFFPOST SUPER USER
No death panels
There's no man with a trumpet. Only me.
08:04 AM on 02/17/2011
Other than for nausea and as an appetite stimulant there's no phase 3 data proving marijuana has any medicinal value. So it's not illegal as a medicine, it's just illegal to use it to treat conditions it's not proven to help.
01:47 PM on 02/18/2011
And what do you think people did for booze during prohibition? Cough syrup. It's all connected, and saying alcohol is ok to be legal but weed is not is absolute insanity, check out any ER on the 4th of July.
05:02 PM on 02/16/2011
I am not surprised! Why would we expect "integrity" from our government leaders when far too often they prove just the opposite! You have to question what they are so scared of !?! There are plenty of studies intiatied by the government that say time and again that cannabis is of medicinal value! Google "studies the feds wish they'd never done"... and see for yourself! www.MedicalMarijuana.com
02:17 PM on 02/16/2011
Marijuana is the safest drug with actual benefits for the user as opposed to alcohol which is dangerous, causes addiction, birth defects, and affects literally every organ in the body. Groups are organizing all over the country to speak their minds on reforming pot laws. I drew up a very cool poster for the cause which you can check out on my artist’s blog at http://dregstudiosart.blogspot.com/2011/01/vote-teapot-2011.html Drop in and let me know what you think!
12:18 PM on 02/16/2011
'If people let the government decide what foods they eat and what medicines they take, their bodies will soon be in as sorry a state as are the souls of those who live under tyranny.' ~Thomas Jefferson

It's time to throw some more Tea in the harbor! Learn what the Tea Party is all about, it is NOT the Republican party! It is a nonpartisan grass roots movement by We The People. The core values of the Tea Party are:Constitutionally limited Government, Fiscal responsibility and Free Markets.

Put an end to big Government and get Uncle SHAM out of your private life!

Put Ron Paul in the Whitehouse in 2012 or sooner! He supports We The People and the Constitution better than any Federal public servant we have. He can't be bought by crooked corporations and his voting record proves it!

"The first truth is that the liberty of a democracy is not safe if the people tolerate the growth of private power to a point where it becomes stronger than their democratic state itself. That, in its essence, is fascism - ownership of government by an individual, by a group, or by any other controlling private power.” Franklin D. Roosevelt
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dgmeansit
03:44 PM on 02/17/2011
I agree that Ron Paul would be a great choice for this country. I also think that Gary Johnson would be very good indeed!
06:27 AM on 02/18/2011
I wouldn't mind a bit if Ron Paul picked Gary Johnson for his VP!

I'd love to see him appoint Judge Andrew Napolitano to the Supreme Court too!

The ONLY way we are going to see "Change we can believe in" is if "We The People" make it happen. That's exacly what's going on with the Tea Party... WE THE PEOPLE ARE TAKING ACTION! It's not about a particular party, left, right, or anything except getting the crooks out of office that are ignoring the Constitution and the Freedom and Liberty it documents and replacing them with Constitutionally minded PUBLIC SERVANTS..
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dgmeansit
11:46 AM on 02/16/2011
The DEA is one of the biggest wastes of taxpayer dollars and still our Govt continues to support it. Recently, President Obama started trying to control spending in this country. He suggests that, among other truly good things, that tax dollars should not be used to help needy families pay for fuel during cold winters. Funding to help students pay tuition should be cut. On and on - BUT - no mention of any cuts in the DEA's budget! So, I get the impression (and I'm pretty sure it's an accurate one) that they have no intention of doing the right thing, which is to legalize pot and stop busting good otherwise law-abiding Americans. It is clear that the DEA knows exactly what medical benefits that marijuana may hold and yet they continue their hardline against research; that is, unless it furthers their cause which is to keep it from ever being legalized. This in spite of the fact that if we had a nationwide vote on whether it should be legalized or not, it would probably be voted legal! They don't care what we the people want. They don't care that countless lives have been destroyed by their often brutal policies and tactics. They don't care that people truly benefit from it's use (both the sick and those that are healthy). The DEA's mission should be redefined such that they are directed to help (and I do mean HELP) people that need it and leave the rest of us
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HUFFPOST SUPER USER
flhu
I get angry, but at the right things.
04:54 PM on 02/16/2011
It's obvious that the DEA has in business to help business. They approve drugs that only slightly work and have incredibly bad side-effects all the time because it has the backing of some multiBillion$ corporation and the DEA will take their word that it works. They also still believe that one puff of grass will lead users into bloodlust and cause a black man to not only look at a white women twice, but have the nerve to step on a white man's shadow. (These are the original arguments for prohibition)
11:52 PM on 02/16/2011
Uh… The Drug Enforcement Agency doesn't approve drugs at all. That's the job of the Food & Drug Administration. It's the FDA that's in the pocket of Big Pharma.
11:25 AM on 02/16/2011
They even ban synthetic weed at the slightest hint of anybody enjoying themselves. Our government is in place to control us and the re-named it "Freedom". George Washington is disgusted.
DrSnuggles
You label me and I'll label you
01:01 PM on 02/17/2011
Ehh, your mileage may vary on the synthetic weed point you made. Marijuana has been smoked for centuries and centuries - whether or not we have a dirth of clinical trials, the generalities of its use are pretty obvious.

However, alot of these synthetic products are created and then just sold, we have NO idea what effect they may have in the long run.
10:37 AM on 02/16/2011
Marijuana has been repeatedly proven to NOT cause cancer, heart disease, brain damage, liver disease, emphysema, or overdoses, and its addictive potential is about on par with coffee. The DEA is 100% misinformed when it calls marijuana "extremely harmful"!

The marijuana prohibition empowers drug dealers and cartels, and makes our children LESS safe! Because of the failings of the prohibition, our children now have easier access to marijuana than to alcohol! We parents have been patient long enough, we must speak up and demand that marijuana be legally sold to adults in gas stations and supermarkets just as beer and wine are today!

We need laws based on LOGIC, not ideology! We need to Legalize Adult Marijuana sales!!
10:52 AM on 02/16/2011
The DEA isn't misinformed. The DEA is spreading disinformation.
billstewart
Not a micro-biologist
04:06 PM on 02/19/2011
Coffee is far more addictive than marijuana, which doesn't give you days of withdrawal headaches if you stop using it. MJ's not entirely safe, but it's certainly far safer than alcohol.