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A Winning Game Plan for the Decade of Vaccines

Commented May 23, 2012 at 16:58:54 in Impact

“While it is certainly true that the risk of experiencing complications from infectious diseases is higher in developing countries suffering with poverty, compromised sanitation and nutrition and limited access to health care services,  the National Vaccine Information Center maintains that parents in these countries should have the basic human right to make fully informed, voluntary choices about use of pharmaceutical products and medical interventions that carry risks., including vaccination, as a basic human right. There are individual biological risks associated with vaccination and recognized gaps in vaccine safety science, which should be acknowledged. 

The National Vaccine Information Center (NVIC) is dedicated to the prevention of vaccine injuries and deaths through public education and to defending the informed consent ethic in medicine. As an independent clearinghouse for information on diseases and vaccines, NVIC does not advocate for or against the use of vaccines but supports the availability of all preventive health care options, including vaccines, and the right of consumers to make educated, voluntary health care choices.  http://www.nvic.org/

blissnsmiles on May 24, 2012 at 11:12:25

“Informed consent!!! Thank you! F&F”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 17, 2012 at 07:22:25 in Healthy Living

“As you have acknowledged, pertussis toxin (PT) is a component of both DPT and DTaP vaccines and the companies selling these vaccines claim that PT is completely chemically detoxified. However, chemically detoxified pertussis toxin may revert to toxicity. It is unknown how often this happens but third generation pertussis vaccines, that do not rely upon chemical detoxification, may offer safer alternatives.

The majority of evidence in the medical literature confirms that pertussis vaccine can cause brain inflammation and permanent brain damage in previously healthy children and can exacerbate pre-existing neurological disorders in other children. It is no secret that some children are biologically more vulnerable to adverse responses to vaccination. The Institute of Medicine acknowledged increased individual susceptibility in the most recent 2011 IOM report "Adverse Effects of Vaccines: Evidence and Causality," highlighting the need to fill in the gaps in vaccine safety science.

The claim that all previously healthy children developing brain dysfunction are pre-destined to become permanently brain damaged, whether or not they are given DPT or DTaP vaccine (or other vaccines), is an untested hypothesis. It must be tested with methodologically sound prospective, case controlled studies comparing the health outcomes of two large groups of children, those who get vaccinated and those who do not, and include analysis of genetic and other biomarkers for all children enrolled.”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 16, 2012 at 16:50:25 in Healthy Living

“Three very small retrospective studies do not prove that every child, who develops seizures or encephalopathy after pertussis vaccination, has the genetic mutation you claim is responsible for every case of post DPT or DTaP regression ending in permanent brain damage. Wishing does not a truth make.”

BE Patienz on May 16, 2012 at 19:19:19

“"The retrospective studies to which you refer do not confirm that the children had "pre-existing" genetic "mutations" that explain their brain damage."

Could you please explain your comment above to the effect that a mutation that is responsible for the production of an abnormal protein in neurons but which is present in the nuclear DNA of cells throughout the body (e.g., also in peripheral blood cells) did not pre-exist post-natal exposure to a vaccine? Since construction of such mutations in rodent models alters the performance of voltage-gated sodium channels and produces seizure disorders following a period of apparently normal development, mirroring the situation in humans, you of course cannot argue that such mutations do not cause such disorders, since they so clearly do so and in a manner unrelated to vaccination, so I'm guessing that your objection might be based on a wacky idea that somehow vaccination caused the mutation. Could you expand on that in a way that makes some sense in the light of what is known about developmental biology, molecular biology, and genetics?”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 16, 2012 at 08:27:47 in Healthy Living

“The retrospective studies to which you refer do not confirm that the children had "pre-existing" genetic "mutations" that explain their brain damage. The children were not tested prior to being vaccinated. To scientifically test your hypothesis that pertussis vaccine never causes brain inflammation/encephalopathy in children without the "pre-existing mutations" to which you refer, a large prospective, case controlled study would have to be conducted in a child population that represents the genetic diversity of the U.S. child population and compares the health outcomes of children, who receive the current federally recommended schedule of 5 acellular pertussis containing vaccines by age six with children in the control group, who receive no pertussis containing vaccines. Testing for the "pre-existing mutations" would have to be performed on all children enrolled at the outset of the study before any vaccines are given. But you already know that.”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 15, 2012 at 23:17:05 in Healthy Living

“Pertussis toxin, which is a lethal toxin primarily responsible for the encephalopathic complications of B. pertussis whooping cough and also helps stimulates immunity, is a bioactive component of whole cell pertussis vaccine and is also contained in acellular pertussis vaccine. Pertussis toxin has been used for many years by researchers in lab experiments to deliberately induce experimental autoimmune encephalomyelitis (EAE) in animals. Three small studies do not wipe out 70 years of evidence that pertussis vaccine causes acute brain inflammation and encephalopathy in a subset of previously healthy children, as well as in those with pre-existing genetic and biological vulnerabilities that increase individual susceptibility. Deal with it. If vaccines never cause brain injury or death - which would make vaccines the only pharmaceutical product incapable of causing injury or death - then Congress should repeal the 1986 law shielding pharmaceutical corporations and pediatricians from civil liability for vaccine-related injuries and deaths so the civil court system can be utilized to confirm your hypothesis.”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 15, 2012 at 21:43:49 in Healthy Living

“The 1994 review was with regard to whole cell DTP vaccine. That science stands and resulted in replacement with the DTaP vaccine shortly following. The case you have presented was with regard to a DTaP case. The fact that two claimants have been denied compensaton because of a pre existing mutation in no way translates into "with most of those awards going to children who were in fact not injured by vaccines," as you previously claimed, i.e. finding one pre-existing mutation does not mean that every child harmed by DTP or DTaP has this particular mutation. Again the study you are referring to was a very small study and one that you failed to cite. Your implication was that this study nullified all pre-existing DTP and DtaP science and claims and that is simply not the case. Also, encephalopathy is listed as both a contraindication to and potentially severe adverse reaction to DTaP as well as DTP, as found in the package insert of Infanrix as one example. http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm101568.htm

BE Patienz on May 17, 2012 at 23:09:21

“"The companies selling these vaccines claim that PT is completely chemically detoxified. However, chemically detoxified pertussis toxin may revert to toxicity."

As you undoubtedly know, the dose makes the poison.

Could you please clarify how much of the chemically-detoxified pertussin toxoid in a vaccine reverts to an enzymatically-active form, how much enzymatically-active toxin is required to produce encephalopathy, and how the amount of the toxoid that is contained in a vaccine and reverts to an enzymatically-active form compares to the amount of enzymatically-active toxin required to produce encephalopathy? Otherwise, no matter how scary-sounding it might seem, your statement is obviously meaningless.

Thanks.”

BE Patienz on May 17, 2012 at 22:31:10

“Although your suggested case-controlled study sound sounds so . . . sciencey, I suppose that you must understand that calling for a large prospective study including “analysis of genetic and other biomarkers” is of course a completely political gesture rather than a meaningful scientific effort.

The incidence of Dravet syndrome, an SCN1A-associated cause of acute encephalopathy following a period of normal development whch happens to manifest at about the time that children are vaccinated against pertussis, is about 1/40,000. (Myriad other SCN1A mutations cause other seizure phenotypes, and many other seizure disorders have been associated with other mutations.)

The Institute of Medicine (long before the current molecular genetic evidence was available) accepted that the risk of encephalopathy following DTP vaccination was ca. 5.25/1,000,000 immunizations, or roughly 1/40,000 children vaccinated [Vaccine. 1993 Nov;11(14):1371-9], although in a study of more than 2 million children, DTP vaccination was _not_ associated with an increased risk of encephalopathy [Pediatr Infect Dis J. 2006 Sep;25(9):768-73]. Analysis of more than 400,000 children showed _no_ increased risk of seizure following DTaP [Pediatrics. 2010 Aug;126(2):263-9]. I supose that, over all, the available evidence quite clearly suggests that the incidence of encephalopathy following DTaP vaccination should be very much lower than that following DTP vaccination.

How many millions of children do you think should be prospectively phenotyped and genotyped to answer this question, and how much do you think this would cost? Could you please show your work?”

Nvic FactCheck on May 17, 2012 at 07:22:25

“As you have acknowledged, pertussis toxin (PT) is a component of both DPT and DTaP vaccines and the companies selling these vaccines claim that PT is completely chemically detoxified. However, chemically detoxified pertussis toxin may revert to toxicity. It is unknown how often this happens but third generation pertussis vaccines, that do not rely upon chemical detoxification, may offer safer alternatives.

The majority of evidence in the medical literature confirms that pertussis vaccine can cause brain inflammation and permanent brain damage in previously healthy children and can exacerbate pre-existing neurological disorders in other children. It is no secret that some children are biologically more vulnerable to adverse responses to vaccination. The Institute of Medicine acknowledged increased individual susceptibility in the most recent 2011 IOM report "Adverse Effects of Vaccines: Evidence and Causality," highlighting the need to fill in the gaps in vaccine safety science.

The claim that all previously healthy children developing brain dysfunction are pre-destined to become permanently brain damaged, whether or not they are given DPT or DTaP vaccine (or other vaccines), is an untested hypothesis. It must be tested with methodologically sound prospective, case controlled studies comparing the health outcomes of two large groups of children, those who get vaccinated and those who do not, and include analysis of genetic and other biomarkers for all children enrolled.”

BE Patienz on May 16, 2012 at 21:14:12

“"Pertussis toxin, which is a lethal toxin primarily responsible for the encephalopathic complications of B. pertussis whooping cough and also helps stimulates immunity, is a bioactive component of whole cell pertussis vaccine and is also contained in acellular pertussis vaccine. Pertussis toxin has been used for many years by researchers in lab experiments to deliberately induce experimental autoimmune encephalomyelitis (EAE) in animals."

You should know, of course, that DTP and DTaP vaccines do NOT contain pertussis toxin, so, while that information is interesting, it is completely irrelevant in the context of this discussion. I suppose that either you actually know that there is no "toxin" in these vaccines and you are intentionally spreading scary-sounding misinformation or you simply don't understand even enough basic biology to appreciate the difference between a toxin and a toxoid.

The inactivated toxoid simply cannot do what the toxin does: ADP-ribosylate G protein and interfere with signal transduction. However, the toxoid does stimulate an immune response that is appropriately protective against B. pertussis infection.

Sheesh.”

Nvic FactCheck on May 16, 2012 at 08:27:47

“The retrospective studies to which you refer do not confirm that the children had "pre-existing" genetic "mutations" that explain their brain damage. The children were not tested prior to being vaccinated. To scientifically test your hypothesis that pertussis vaccine never causes brain inflammation/encephalopathy in children without the "pre-existing mutations" to which you refer, a large prospective, case controlled study would have to be conducted in a child population that represents the genetic diversity of the U.S. child population and compares the health outcomes of children, who receive the current federally recommended schedule of 5 acellular pertussis containing vaccines by age six with children in the control group, who receive no pertussis containing vaccines. Testing for the "pre-existing mutations" would have to be performed on all children enrolled at the outset of the study before any vaccines are given. But you already know that.”

BE Patienz on May 15, 2012 at 23:29:14

“Yep, 25 of 28 children in three separate studies who allegedly suffered vaccine reactions when injected with pertussis vaccine turned out to have pre-existing mutations that entirely explained their disorder, and the other 3 of 28 children had different defined epilepsy syndromes that have been associated with other mutations. Indeed, older studies suggested that pertussis vaccine seemed to cause acute brain inflammation and encephalopathy in a subset of previously healthy children, and now we know why: the available evidence clearly suggests that such children have epilepsy syndromes that explain their symptoms, and almost all such children studied at the molecular genetic level have pre-existing mutations in a single particular gene that entirely explains their symptoms.”

Nvic FactCheck on May 15, 2012 at 23:17:05

“Pertussis toxin, which is a lethal toxin primarily responsible for the encephalopathic complications of B. pertussis whooping cough and also helps stimulates immunity, is a bioactive component of whole cell pertussis vaccine and is also contained in acellular pertussis vaccine. Pertussis toxin has been used for many years by researchers in lab experiments to deliberately induce experimental autoimmune encephalomyelitis (EAE) in animals. Three small studies do not wipe out 70 years of evidence that pertussis vaccine causes acute brain inflammation and encephalopathy in a subset of previously healthy children, as well as in those with pre-existing genetic and biological vulnerabilities that increase individual susceptibility. Deal with it. If vaccines never cause brain injury or death - which would make vaccines the only pharmaceutical product incapable of causing injury or death - then Congress should repeal the 1986 law shielding pharmaceutical corporations and pediatricians from civil liability for vaccine-related injuries and deaths so the civil court system can be utilized to confirm your hypothesis.”

BE Patienz on May 15, 2012 at 23:15:52

“"That science stands."

I suppose that might be true if you were the one to decide--but you're not. Just so you know.”

BE Patienz on May 15, 2012 at 22:23:53

“Three molecular genetic studies from independent groups of investigators on three continents examined children who had suffered alleged vaccine-induced encephalopathy following DTP. ALL of the children in the studies were found to have defined epilepsy syndromes; almost all had a mutation in the single gene of interest--a finding that is not surprising since a minority of such cases have been shown to be caused by mutations in other identified genes. (To date over three hundred mutations in that gene [SCN1A] have been associated with a syndrome which involves the development of encephalopathy and/or seizure disorders following a period of apparently normal development, often accompanied by the development of autistic traits.)

Gene expression studies demonstrate that the product of the mutant gene is produced at low levels at birth and then increases to maximal expression at around the time when the syndrome appears, which happens to coincide in humans with the time frame of DT(a)P exposure. Mutant mice and rats that similarly develop SCN1A-related seizure disorders following a period of apparently normal development do so without exposure to vaccines. The fact that encephalopathy is listed on the package insert does not indicate that vaccination actually causes encephalopathy, but simply that it has been reported following vaccination--but you must know that.”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 15, 2012 at 18:36:49 in Healthy Living

“What we know is that 1) Congress designed a Table of Compensable Events to assist special masters in the Vaccine Court in awarding compensation to those suffering chronic brain and immune system dysfunction following vaccination when a more plausible biological explanation could not be found. I.E. causation would be "presumed" in the absence of a more plausible biological explanation. The Table of Compensable Events lists symptoms of acute brain inflammation and encephalopathy, as well as other signs of vaccine complications.
2) The whole cell pertussis (whooping cough) vaccine is one of the most reactive and marginally effective vaccines on the market . The pertussis "research" to which you refer that you allege refutes more than 70 years of medical literature giving evidence that pertussis vaccine can cause permanent brain damage is a retrospective study of 14 children conducted by the Australian National Health and Medical Research Council. You are citing a study of 14 children to invalidate the pertussis vaccine injury awards made in the federal vaccine injury compensation program? Seriously? In 1994, the Institute of Medicine acknowledged that a reanalysis of the large prospective, case controlled National Childhood Encephalopathy Study (NCES) of 1,000 children published in Britain in 1981 provided strong evidence that the whole cell pertussis vaccine can cause encephalopathy within 7 days of receipt of DPT vaccine by previously healthy children and lead to chronic neurological dysfunction.”

BE Patienz on May 16, 2012 at 10:10:04

“"The retrospective studies to which you refer do not confirm that the children had "pre-existing" genetic "mutations" that explain their brain damage. "

Of course they do exactly that, and they are supported by other molecular genetic studies including those that show that in animal models seizure disorders develop in animals which are not vaccinated but which carry such mutations. .”

BE Patienz on May 15, 2012 at 20:11:59

“How interesting that you invoke a 1994 review in an attempt to refute research that was conducted years later. Two different research groups have demonstrated that children who allegedly suffered encephalopathy following vaccination against pertussis in fact had pre-existing (de novo) mutations that entirely explain the syndrome; unvaccinated rats and mice that carry such mutations follow similar develomental courses. Recent decisions by the "vaccine court" explain this; for example:

http://www.uscfc.uscourts.gov/sites/default/files/SMGOLKIEWICZSTONE041510.pdf

You are quite right that "Congress designed a Table of Compensable Events to assist special masters in the Vaccine Court in awarding compensation to those suffering chronic brain and immune system dysfunction following vaccination when a more plausible biological explanation could not be found." A more plausible biological explanation HAS been found. Deal with it.”
Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Shot@Life: Amanda Peet, United Nations Foundation Team Up For Vaccination Campaign In Developing Countries

Commented May 15, 2012 at 10:09:17 in Healthy Living

“This article seems quite disjointed. The title tells us that the story will be about the launch of a United Nations vaccine campaign targeted at developing countries, yet the focus is on criticizing American parents who have concerns regarding vaccine safety and labeling those parents “anti-vaccine.” Dr. Paul Offit tells us how frustrated he is with parents in America, “But when studies show that vaccines aren't associated with that concern (Autism & AD(H)D), and people still don't believe it, that's what gets frustrating. It's not scientific illiteracy, it's scientific denialism." However, vaccines most certainly come with risks and do injure some people which is why we have a federal vaccine court that has paid out more than $2 billion in vaccine injury claims since the late 1980s. In addition the gaps in vaccine safety science are well defined. The recent Institute of Medicine Immunization Safety Review acknowledged out of 158 serious brain and immune system disorders, including autism, reportedly associated with eight different commonly used vaccines, there were either no studies or too few methodologically sound studies to make a causation determination either way for 135 (85%) of them. Consumers are beginning to demand that these gaps be filled. We have a right to know the true risk/benefit associated with every vaccine and the right to informed consent and choice.

For more on the Human Right tot Informed Consent http://www.nvic.org/NVIC-Vaccine-News/August-2011/The-Health-Liberty-Revolution---Forced-Vaccination.aspx

BE Patienz on May 15, 2012 at 13:17:04

“As you should know, (1) the compensation awarded by the "federal vaccine court" was determined based not on proof of vaccine injury but on a good-faith effort to award compensation in cases where the injury might have been related to vaccination ("50% plus a feather"), and (2) about half of those payments were in cases in which seizure disorders and/or encephalopathy were claimed to have resulted from vaccination against pertussis, although subsequent research showed that those disorders were due to pre-existing mutations and were not caused by vaccination. You thus are claiming that because awards were made, by design, in cases where there was no requirement of proof of vaccine injury and with most of those awards going to children who were in fact not injured by vaccines, it is proof that vaccines are bad.”
Shots for School: Keeping Kids Safe -- Together

Shots for School: Keeping Kids Safe -- Together

Commented May 13, 2012 at 19:44:42 in Parents

“Our response was with reference to "vaccines" in general as the author is talking about the safety of vaccines in general not one specific vaccine. Again, IOM found that, out of 158 serious brain and immune system disorders reportedly associated with eight different commonly used vaccines, there were either no studies or too few methodologically sound studies to make a causation determination either way for 135 (85%) of them. Extensively searching for evidence and finding "no studies or too few methodologically sound studies" is in NO WAY encouraging. It means those responsible for managing our vaccine program (our government) have made no or very little effort.”
Shots for School: Keeping Kids Safe -- Together

Shots for School: Keeping Kids Safe -- Together

Commented May 11, 2012 at 12:41:46 in Parents

“While your statics on death and injury are correct with regard to Meningococcal disease one must consider the extremely rare incidence of the disease to put this issue into proper perspective.

Meningococcal disease is extremely rare in the United States and the vast majority of the population has natural immunity that might be disrupted through widespread vaccination. At any given time up 20 to 40 percent of us are asymptomatically colonizing meningococcal organisms in our nasal passages and throats, which throughout life boosts our innate immunity to invasive bacterial infection.14, 15 By the time American children enter adolescence, the vast majority have asymptomatically developed immunity that protects them. In our population of 308 million, there are between 1400 and 3000 cases every year that fluctuate with natural cycles.6 .

The good news is that the incidence of the disease has decreased more than 60 percent between 1998 and 2007 to less than 1 case in 100,000 people and given a 10 to 15% death rate that means 1 to 1.5 people in a million die from Meningococcal disease. Given the vaccine involves risk, the extremely small chance that one would even contract this disease puts into question the logic in mandating the vaccine for the entire population of children and adolescents.
http://www.nvic.org/NVIC-Vaccine-News/July-2011/What-You-Should-Know-About-Meningococcal-Disease--.aspx#_edn6

National Vaccine Information Center - Your Health. Your Family. Your Choice. http://www.nvic.org

Dyson on May 13, 2012 at 17:19:51

“The incidence of disease has declined *because* of vaccination.
It is still a dangerous disease. It is worth risking a tiny chance of a vaccine reaction that is not likely to be serious, as compared to a tiny chance of catching the disease with a high chance of serious disabling disease and high mortality.”
Shots for School: Keeping Kids Safe -- Together

Shots for School: Keeping Kids Safe -- Together

Commented May 11, 2012 at 10:13:58 in Parents

“Parents researching vaccine safety see a huge disconnect between the well defined gaps in vaccine safety science and assurances they hear from their doctors.

You say about vaccines that, “They are carefully tested before being licensed and continuously monitored afterwards and the most common problems are minor, but serious problems do occasionally happen.” However, the Institute of Medicine recently issued a report on vaccine safety that acknowledged there is not enough quality vaccine science in the medical literature to determine whether or not many of the vaccines routinely given to children and adults cause more than 100 different types of brain and immune system dysfunction. IOM found that, out of 158 serious brain and immune system disorders reportedly associated with eight different commonly used vaccines, there were either no studies or too few methodologically sound studies to make a causation determination either way for 135 (85%) of them. These are serious inflammatory brain and immune system disorders and range from heart and blood disorders to strokes, sudden infant death syndrome, asthma, multiple sclerosis, fibromyalgia, GBS, rheumatoid arthritis, lupus, diabetes and encephalitis that can lead to seizures, learning disabilities and autism. In addition they acknowledged there are pre-existing biological susceptibilities that can make some individuals more vulnerable than others for suffering harm from vaccination and scientific inquiry into understanding these biological susceptibilities is virtually non-existent. http://www.nap.edu/openbook.php?record_id=13164&page=70

National Vaccine Information Center - Your Health. Your Family. Your Choice. www.nvic.org

Dyson on May 13, 2012 at 17:30:10

“There is specific research on parents perceived risks with this vaccine versus the risks from the disease.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279114/?tool=pubmed

The IOM did a very extensive search for evidence linking the vaccine to the reputed problems ascribed to it. They found no evidence or inadequate evidence, which is encouraging.”

Mykidsma on May 11, 2012 at 16:56:04

“So true! I recently read an article where an MD was using this same IOM study to try to support vaccine safety. Hjs basic argument was that the studies are not being done because there's no need for them. Now, that gives an educated parent a warm-fuzzy feeling to know just where safety sits on the priority list for your doctor!! Ugh.”