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dougdela's Comments

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Autism: A Year In Review

Autism: A Year In Review

Commented Jan 6, 2012 at 21:14:55 in Education

“I'm very surprised that no one has mentioned the recent CBC (Canada) "Nature of Things" program that presented film evidence from a Chicago family, of remission from severe autism by treatment with Vancomycin. The theory is that Clostridium bacteria in intestines produce neurotoxins. The child re-developed the symptoms when the antibiotic was discontinued. Ethiopian community in Toronto shows a spike in Autism cases unlike their relatives back home. They are investigating changes in diet for possible causes.
http://www.cbc.ca/video/#/Shows/The_Nature_of_Things/1242300217/ID=2175032196”

John Richard Smith on Jan 7, 2012 at 02:14:13

“I remember that story because it indicated dysregulation in the gut of ASD kids.

Laura de Magistris and colleagues at the Second University of Naples reported that 48% of 90 autism spectrum disorder (ASD) patients patients have GI problems

Williams, Buie et al in 2011 also looked at the gut and microbiome

http://www.ncbi.nlm.nih.gov/pubmed/21949732

* The GI problems experience­­d in the two groups ... were similar with the majority suffering from food allergies.­­..

* Regression - 2008 -Cases had a high rate of CPEA-defin­­ed behavioral regression (loss of language and/or other skills following acquisitio­­n), 88%, compared to published rates of 20–40% for the general ASD population

* Regression 2011 - 87% of AUT-GI subjects in our study had behavioral regression­­.

* gene expression analysis indicated that...14 out of the 15 autistic children had deficienci­­es in expression

* Expression levels of disaccharidases and transporters were associated with the abundance of affected bacterial phylotypes. These results indicate a relationship between human intestinal gene expression and bacterial community structure and may provide insights into the pathophysiology of gastrointestinal disturbances in children with autism.

That shows quite clearly a relationsh­ip between GI disease / immune system and "Regressio­n" in Autism.

To my mind it also highlights what John Walker-Smi­th and his team were trying to initialy elucidate in 1998 a unique GI process / disease pathology. How ever it should be worded.

It also highlights that parents were reporting a real rather than imagined event ...”