I can't emphasize enough how important it is to really know what your body and mind are trying to tell you. We're all here for our own individual purpose, and if you don't listen to it and only treat these signs as symptoms of a disease that you treat purely through external remedies, you'll have lost yourself in the process.
Let go of what's not working. Be brave enough to move on. Make bold choices. It's okay if they're last minute, split second, or otherwise -- as long as you're following your inner-voice. Be audacious enough to ask the driver to stop the bus so you can jump off and see what adventures are waiting for you.