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Documentary Links Marijuana Use with Psychosis, Schizophrenia

Posted: 01/28/10 12:30 PM ET

Most anti-drug education is about as effective as encouraging teens to get up at dawn on the weekends. Maybe, just maybe, because the delivery style (earnest videos, posters with smiling teens, italic fonts and exclamation marks!) tends to both misunderstand and misrepresent teen culture.

In most cases, it's as if the whole effort was designed by aliens. Or about as ridiculous as teens telling boomers how to behave. When I was a high school teacher, I sometimes wondered if the anti-drug efforts had the same effect on decreasing drug use as teen abstinence campaigns do on decreasing teen sex and pregnancy: i.e. the opposite.

So I raised an eyebrow when one of the main researchers profiled in a new documentary called The Downside of High, said, with a little smile, that most people have fun on weed and no problems. The documentary, which follows the stories of three teenagers, takes a scientific and surprisingly nonjudgmental approach.

"The vast majority of us drink alcohol; the vast majority of us come to no harm. Same with cannabis. The vast majority of people have nothing but enjoyment from it," said Dr. Robin Murray from the Institute of Psychiatry at the University of London.

However, he goes on to explain why--even though he was initially dismissive of patients' questions about the possible link between weed smoking and their psychosis and even schizophrenia--he was convinced after reading a now-famous Swedish paper that followed the health of 50,000 Swedish military recruits over 15 years, and the subsequent research that has come out over the last decade or so. In short, people who start smoking marijuana before the age of 16 are four times more likely to develop schizophrenia.

Another researcher, Dr. Jim Van Os of the University of Maastricht said, "by the mid-'80s, we started to observe that 80 to 85 percent of people who came in with their first psychotic episode were smoking marijuana."

Even in response to these numbers, Murray is cautious. He says that "everyone varies in their genetic susceptibility. Some of us can happily take cannabis without developing a problem; others of us are more prone." But it turns out the very few who are "prone" have a pretty bad time with it.

Ben, one of the teens profiled in the documentary, says most of his friends regularly smoke pot with no problems. But that when he was about 16 and smoking weed, he started thinking there was an exorcist demon in his house. He says he then started to think there was a little guy with a knife creeping around his house trying to kill him and an anaconda snake that was going to get him, then digest him slowly.

At a screening of the film at North Vancouver's Balmoral high school, he told an audience of 250 grade-eight kids that he thought there were voices speaking to him through the TV, and that he started seeing trolls. "I looked out of my window at the terrace and thought I saw trolls. You know like in Harry Potter, that big guy? Like that."

After jumping off the roof twice, he was admitted to hospital, where he stayed for over a year. At the screening, he said that the reason he didn't stop smoking weed right away was that the psychosis came on so gradually. "It's kind of like landing a plane. It's slow. You lose your memory. You lose you cognitive skills." Shaking, but speaking loudly over the loud, grating noise of the cafeteria's fridge and fans, he said, "But then you end up spending a lot of time in the hospital which is, um, lonely. You don't want to be in the hospital: you just kind of talk in blather. And, um, you have to take your medication or it gets like that again." Gulp.

David Suzuki, the narrator, says that psychosis is a temporary but frightening state filled with intense anxiety and hallucinations, and when people attribute too much meaning to routine or mundane events. For some people, it's a symptom of schizophrenia.

Dr. Shimi Kang, a psychiatrist from B.C.'s Children's Hospital who specializes in drug and alcohol-related psychosis, and who was at the screening, says psychosis often comes with paranoia: like if you're paying for something at the supermarket and the clerk calls for a price check. "You think they're actually calling someone over to harm or kill you."

Dr. Kang says they're seeing "lots and lots more problems with marijuana than we ever have before. Patients will say to me, 'Dr. Kang, I don't see why I have to come and see you and why I'm having these problems. My dad used to smoke pot and he was just fine."

So what is the problem? As kids at the screening pointed out, people have been smoking weed for centuries. It's organic. Hippies and happy people smoke it to relax and feel good. Teens' parents smoked and smoke weed, and are totally fine.

Turns out weed has changed a lot since the 1960s and 1970s, so much that the U.N. is discussing reclassifying it as a different product. Basically, there's a lot more THC, a hallucinatory chemical, in it now.

Health Canada regularly tests the strength of marijuana confiscated from illegal grow-ops and reports back to the Royal Canadian Mounted Police. Corp. Richard DeLong says in the film that in the 1960s and 1970s, the THC levels were between 1 percent and 3 percent. "We know today what is coming out of our labs is THC of anywhere between 18 percent ... to 25 percent. And that is significant," he says. Given that it's the most widely used illegal drug in the world, that usage in North America doubled in the 1990s, and that it's still rising: that's all pretty different from the 1960s.

For those of you wondering, here's the science of THC and psychosis, as explained by Suzuki. THC, the hallucinogen, triggers an increase in dopamine in the brain. Dopamine is a chemical that controls mood. Dopamine makes us more aware. Too much THC in the brain's circuits, for some people, can trigger too much heightened awareness and cause misplaced meaning.

The film says that though it's conclusive that increased dopamine leads to psychosis and schizophrenia, the basis of the link remains illusive. Researchers suspect that any damaging effects happen when the THC in marijuana interacts with the cannabinoid system, a little-known family of brain chemicals and receptors that is critical to how we process the world around us. Our body's own cannabinoids attach to receptors on the brain's nerve cells. There, they regulate signals passing between the cells.

But THC is also a member of the cannabinoid family. So Murray says that, in some cases, the body's own cannabinoid system is overwhelmed by the cannabis.

Over the last 15 years, since that initial Swedish study, there have been many more studies done in other countries. Os has analyzed them all, and says definitively and conservatively, smoking cannabis nearly doubles a person's risk of developing future psychotic states including schizophrenia, and if someone smokes it before the age of 16, they are four times more at risk.

As the kids file noisily out of the cafeteria, with the backdrop of the green rainforest and gray skies through the windows, a few stopped to talk nervously to the teens, Ben and Tyler, who had their hands in their pockets, shoulders slumped. It's hard not to have an emotional reaction to the stories of the three teens.

But the documentary covers the science and teens' stories without angle, judgment or emotion, which is an unusual approach to the topic of marijuana.

Murray says, "The problem with cannabis is that you have those on the one hand that say it's a sacred herb, and on the other extreme you have people that say cannabis is the work of the devil. But neither of those extremes is practical. What we need is a situation where people know that if you smoke cannabis heavily, particularly if you smoke the potent brands of cannabis, that you're more likely to go psychotic."

This post originally appeared on The Tyee.

 

Follow Vanessa Richmond on Twitter: www.twitter.com/vanessarichmond

Most anti-drug education is about as effective as encouraging teens to get up at dawn on the weekends. Maybe, just maybe, because the delivery style (earnest videos, posters with smiling teens, italic...
Most anti-drug education is about as effective as encouraging teens to get up at dawn on the weekends. Maybe, just maybe, because the delivery style (earnest videos, posters with smiling teens, italic...
 
 
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HUFFPOST SUPER USER
MaryJane Cannabian
Mama. Wife. Writer. Political Junkie, Legalizer
03:12 PM on 02/07/2010
From: International Researchers Reveal Medical Cannabis Breakthroughs!

Excerpts from:

IACM 5th Conference on Cannabinoids in Medicine
2-3 October 2009, Cologne

METABOLIC ABNORMALITIES, ABNORMAL STRESS RESPONSE AND CHRONIC
INFLAMMATION IN SCHIZOPHRENIA – POTENTIAL TARGETS FOR
CANNABINOID MEDICINES?

In recent years much concern has arisen over the possibility that cannabis smoking in adolescence may be a risk factor for schizophrenia in adult life, although this remains a controversial issue. In contrast, considerable interest in the potential role of the non-psychoactive naturally occurring cannabinoid cannabidiol (CBD) as an anti-psychotic medicine has also developed. The anti-inflammatory and immunomodulatory effects of both THC and CBD are well established. A systematic literature review has suggested the intriguing possibility that habitual cannabis use may protect cognitive function in schizophrenia patients, and CBD has been shown to improve a marker of this in healthy subjects.

There are preliminary data to suggest that cannabinoids may have beneficial effects on abnormal stress reaction, metabolic dysfunction and dyslipidaemia. Since the mechanism of action for the anti-psychotic effects of CBD and other cannabinoids almost certainly differs from all existing agents, synergistic combinations withboth typical and atypical antipsychotics are a possibility. Taken overall, these observations lead to the hypothesis that an appropriately formulated medicine containing a combination of selected cannabinoids may have the potential to target all the major components of the schizophrenia syndrome and thereby significantly reduce the need for polypharmacy. Read More: http://maryjanecannabian.blogspot.com/2009/10/international-researchers-reveal.html
02:23 PM on 02/16/2010
I wouldn't mind some Cannabidiol for my schizophrenia. Is there anywhere I can get some?
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HUFFPOST SUPER USER
seerickson
10:43 PM on 02/02/2010
Correlation doesn't not substantiate causation
10:52 PM on 02/01/2010
"The film says that though it's conclusive that increased dopamine leads to psychosis and schizophrena...."
NOPE! Read any decent psychology/psychiatry text, and you'll see THAT'S JUST NOT TRUE. Dopamine is somehow involved, but it is NOT that simple.

After the studies and the documentary, it's still entirely possible (likely, in fact) that prodromal (very early) schizophrenia is causing people to use Cannabis - and NOT the other way around.
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FormerReaganite
Government Regulations Save Lives
11:35 AM on 01/30/2010
There is another angle to pot: the inhalation of heavy amounts of particulate matter, carbon monoxide, and carcinogenic combustion byproducts. Just like tobacco, smoking pot is dangerous to health, and can induce heart attack, stroke, etc. If you must ingest cannabis, the safe way to do it is to bake those cookies...
HUFFPOST SUPER USER
Luna C666
02:05 PM on 02/03/2010
Vaporizer...
09:37 AM on 01/30/2010
I'am in my fifties and started smoking pot when i was 12. It was fun till my first psychotic episode at age 15. Everyone around me were witches and out to get me.Oh that was fun let me tell you. I was scared!!! I stopped smoking after that until freshman weekend getaway at college. We were on a bus going to a dude ranch and the bong was passes around . Well i started smoking again. I smoked everyday there after. From the time I awoke till the time i went to bed. I smoked for 2 years nonstop until I started getting paronoid. People were out to get me. Friends strangers, everyone. I continued smoking cause i thought it would mellow me out and i was addicted!!!!!!!! My paranoid behavoir got so bad that i wound up on anti psychotic meds and stopped smoking. It took a few years for my brain to clear. The problem with pot is you just don't know how it will effect you down the road. My advice is DON'T START.
11:50 PM on 01/29/2010
more fearmongering. thats the latest push they know thay by now most adults are familiar with marijuana so now they say "this isnt the same marijuana you smoked in the 60's now it really is dangerous". luckily most people know better.
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HUFFPOST SUPER USER
CPAwADD
My super power is sarcasm!
02:40 PM on 01/29/2010
Whoa. Buzzkill!
12:19 PM on 01/29/2010
"What we need is a situation where people know that if you smoke cannabis heavily, particularly if you smoke the potent brands of cannabis, that you're more likely to go psychotic."

That is just..flat out...wrong.

If that were indeed the case, we wouldn't have enough mental hospitals in the world to hold all the psychotics.

Cannabis is the most popular drug in the whole world, because it has the least potential for harm and abuse.
12:07 PM on 01/29/2010
In fifty years of cannabis culture, how is it that no one I know ever became schizophrenic who smoked weed?

There are some people who will have an unfortunate reaction to any drug. Just as we see on TV, they warn of side effects including death. Even aspirin kills children every year, yet they can still go buy it in the stores.

This is another hit piece on marijuana, funded by bigpharma or alcohol, because we are drawing closer to decriminalization.

I have to educate all the health professionals I come in contact with about the clinical studies proving that various cannabinoids kill cancer cells in vitro and in vivo.

So, for all of you have not seen the abstracts, go to PubMed, search for cannabinoids and cancer.

Every so often another report comes out trying to prove how dangerous pot is. Yeah, it is dangerous, it makes you think for yourself. It makes you realize that your government is run by gangsters, for gangsters, because here is an herb that over thousands of years has the lowest risk to benefit profile of any substance. Even sugar is more damaging to people's metabolisms in the long run than pot.

Yet, inconceivably, it is kept from people whose lives would have been saved or extended by it's use.

I predict that with the new science of epigenetics it will be learned that generational use of alcohol sets the stage for metabolic disorders including psychotic episodes in subsequent generations.
02:28 PM on 02/16/2010
The CBD from cannabis looks as if it's a good treatment for schizophrenia. People would be more likely to stick to their meds if they had a side effect profile like CBD. It's a shame there isn't a good CBD anti-psychotic by now; I've read that they've known about this since around 2002.
10:50 AM on 01/29/2010
But alcohol and tobacco are good drugs so sayeth the DEA.
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05:03 AM on 01/29/2010
I am one of those people who does not enjoy pot. Not everything about smoking it is negative, but on whole, I would rather not smoke it than do so.
I am self-aware enough to know that the weird things which I experienced while high were induced by the high, but that does not mean that I enjoyed them, if that makes any sense.
12:11 PM on 01/29/2010
But I bet you enjoy a gin martini!
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02:35 AM on 01/29/2010
It is common for teenagers to try cannabis. Schizophrenia typically develops slowly and becomes apparent in the late teens or twenties. One statement does not necessarily prove the other. This may simply be a problem in logic.

Teenagers should not alter their consciousnesses because they don't yet have a firm grip on the common reality, are still growing and neither their bodies nor their brains are not fully developed. However, they do and there is usually no problem unless they get caught and family and/or legal problems arise. Paranoia can be caused by the fact that cannabis is illegal; fear of being detected as being high can cause anxiety.

THC is not a hallucinogen, unless it is an extremely weak one. I've experienced THC and hallucinogens; THC was never had a hallucinogenic effect on me or any cannabis smokers I've known since the '60s.

I've smoked cannabis since the '60s. The THC level may have been lower then, but the effect has always been the same for me. The only difference maybe that it takes less to get that effect. There is a ceiling to the "high"; it is not like drinking where you get more & more drunk the more you imbibe.
That does not happen with cannabis.

This film was screened in British Columbia; BC Bud is the best in terms of length of effect.
01:22 AM on 01/29/2010
Many people with underlying mental issues self medicate with pot.

Many people with underlying mental issues try the "meds" from Big Pharma and come back to pot.

Does pot CAUSE schizophrenia OR are people with the underlying factors that will develop into schizophrenia more likely to find their way to pot?
06:45 AM on 01/29/2010
I had the very same thought. I don't see how the researchers could tell the difference. Self-medicating is extremely common with many types of mental illness, including schizophrenia.
12:37 AM on 01/30/2010
Exactly! My thoughts as well---cause or effect?
That said, I think we should discourage children from using
marijuana because the developing brain is more sensitive to ANY drugs or pharmaceudicals.
And current research suggests it is stil developing (particularly males-- sorry guys) well into their twenties. Until we can approach the problem in a scientific and logical way instead of scare tactics and flawed research, the "war on drugs" is doomed to failure.
12:29 AM on 01/29/2010
I would assume that teens who smoke pot are more likely to use other drugs. That's how it was when I was in high school. We usually did some type of hallucinogen (LSD, magic mushrooms, peyote) once or twice a month, as well as speed, cocaine or opium whenever such drugs were available. Two of my friends also had a serious psychotic episode in those days, but whether it was caused by the pot, the speed, the LSD or some genetic proclivity is hard to say.
11:50 PM on 01/28/2010
I do not believe that anyone should be imprisoned or punished in any way for smoking, eating, or otherwise ingesting marijuana. But I am amazed at all the non-scientists who are SO SURE that it NEVER causes anyone any harm. Smoking marijuana can definitely increase the chance of lung cancer (as can exposure to any smoke). But does that mean, therefore, that if studies show that marijuana will cause lung cancer in some people, that somehow it can be ignored and I can just be called a right-wing moralist? There are billions of people in the world. One major problem with modern medical research is the nonsense that we all need the same thing...the same amount of vitamin C each day, etc. etc. But if our bodies are different, could it be the case that there are some people, especially those with psychological problems, who could be further damaged by marijuana use?
Disregarding all scientific studies that might give someone an "inconvenient truth" about marijuana is as foolish as doing the same for evolution or global warming. And NO -- MOST DEFINITELY--I AGREE THAT MARIJUANA USE SHOULD BE DECRIMINALIZED. But how to all you "experts" know for sure that it can't harm anyone?
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02:41 AM on 01/29/2010
People who smoke NOTHING also get lung cancer.

Never heard of a cannabis smoker getting lung cancer, though I imagine anything can happen.
06:47 AM on 01/29/2010
I think it's obvious that inhaling smoke is bad for you. however, the stoners I've met typically average less than one joint per day. I imagine that anyone smoking only one tobacco cigarette per day would have a much lower cancer risk than the pack-a-day smokers.
09:28 AM on 01/29/2010
Actually, there has been ZERO evidence that pot causes lung cancer...IN FACT, what the FEW studies that have been done have shown a REDUCTION in lung cancer among pot smokers.

They speculate the antioxidant property of the drug actually help protect the lungs.

Even cigarette smokers showed a reduction in cancer rates amongst pot users vs non users.
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HUFFPOST SUPER USER
MaryJane Cannabian
Mama. Wife. Writer. Political Junkie, Legalizer
03:25 PM on 02/07/2010
In 2006, Dr. Donald Tashkin led the largest population case-control study (yes, Dr. Tashkin actually performed research on HUMANS, not ‘CALF THYMUS DNA’) ever to assess the use of marijuana and lung cancer risk. The study, which included more than 2,200 subjects (1,212 cases and 1,040 controls) concluded “What we found instead was no association (between marijuana smoking and cancer) and even a suggestion of some protective (anti-cancer) effect.”

Dr. Tashkin has performed US-government sponsored studies of marijuana & lung function for over 30 yrs. and is considered to be the United States’ — if not the world’s — foremost expert on Cannabis. Read More: “Fox News Infected With “Reefer Madness”
http://blog.norml.org/2009/06/17/fox-news-infected-with-reefer-madness/