Each time major celebrities alter their bodies, they're risking millions of dollars in potential earnings and the livelihoods of their entire teams. With the stakes so high, the effects must be subtle. No one wants to be the next Meg Ryan, whose 2001 misadventures in lip enhancement left America's erstwhile sweetheart looking like a duck, a lapse in judgment at which Hollywood still shudders. "She basically installed a vagina on her face," says producer Clifford Streit (American Psycho), adding helpfully, "When your lips get that big, your eyes look too small." More recently, Rose McGowan lost out on a role in the upcoming film Speed Racer, reportedly because her overstretched eyelids had begun to evoke those of an alien kitten.