03/18/2010 05:12 am ET Updated May 25, 2011

Chelsea Handler's Playboy Interview: How To Have An Inter-Office Hookup

E! host and comedienne Chelsea Handler graces the December cover of Playboy, and in the article she dishes on topics like inter-office hookups, holiday cooking, and why she likes to keep her holidays secular.

"If you drink so much that it seems a good idea to hook up with one of your co-workers, try to do it somewhere a little less public, like a car," Handler says. "If you're going to make a mistake you'll regret tomorrow, you may as well do it somewhere classy."

Handler recently broke up with E! boss Ted Harbert."

Handler told Playboy that she prefers to keep her holidays secular.

""It's time to take back Christmas for those of us who don't want to hear about angels and shepherds and babies with glowing heads," she said. "Besides, ever since Jesus started dating Madonna, I can't take him so seriously anymore. A secular holiday party is a happy holiday party. ... If you're doing it right, Christmas should be a celebration of family and friends and having a good time, with just a sprinkle of porn thrown in."

As for her ideal holiday meal?

"I love a big holiday meal with friends," she said. "And I'm a meat-and-potatoes kind of girl. I like baked hams, mashed potatoes, a big turkey stuffed with Vicodin and extra tryptophan - all the old standards."

The December 2009 issue of Playboy goes on sale Friday, November 13.