06/19/2012 06:19 pm ET

50 Hours, 23 Minutes And 20 Seconds In Portland, Maine

Thanks to locals’ fearsome independent streak, and an influx of young creatives, New England’s second city may have the hippest working waterfront in America. Direct flights from New York, Philadelphia and D.C. make getaways to Portland convenient, and the small downtown, with its great public transportation, allows ambitious travelers to cram in a lot of leisure.

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