"KIlling Kennedy" has cast Rob Lowe and Ginnifer Goodwin as its John F. Kennedy and Jacqueline Kennedy.
The National Geographic movie, based on Bill O'Reilly and Martin Dugard's book of the same name, will also star Michelle Trachtenberg as Marina Oswald.
"Killing Kennedy" starts in 1959 with JFK (Lowe) announcing his candidacy for president and Lee Harvey Oswald in the US embassy in Moscow renouncing his US citizenship.
Production on "Killing Kennedy," which was penned by Kelly Masterson and will be directed by Nelson McCormick, is set to begin in June in Richmond, Va.
"We are thrilled to be working with Rob Lowe, Ginnifer Goodwin and Michelle Trachtenberg, three gifted artists whom have responded to this timely, authentic and entertaining material," Howard T. Owens, president of the National Geographic Channels, said in a statement. "With 'Killing Kennedy,' timed to coincide with the 50th anniversary of the assassination of JFK, National Geographic Channel continues to bring daring, culturally significant television events to our growing global audience."