08/27/2013 12:31 pm ET

'Dallas Buyers Club' Trailer: Matthew McConaughey's Oscar Ticket? (VIDEO)

All right, all right, all right: The first trailer for "Dallas Buyers Club" debuted on Tuesday, offering an official glimpse at Matthew McConaughey's transformative lead performance in Jean-Marc Vallée's new film. McConaughey lost nearly 50 pounds to play Ron Woodroof in "Dallas Buyers Club," a heterosexual Texas man who was diagnosed as HIV-positive in 1986 and soon after began smuggling effective, non-approved drugs into the United States to help stricken patients. Jennifer Garner and Jared Leto co-star in the film, which Focus features will unveil in limited release on Nov. 1.

Fall Movie Preview 2013