Amy Schumer has a sharp wit that might intimidate some. But Downing hasn't lived 106 years on this planet to let the cable comic tell jokes at her expense.
Watch above as the centenarian holds her own with the funny lady in an "Inside Amy Schumer" interview.
They talk condoms, weed, Twitter, fashion, heavy drinking and even racism.
But if Downing has learned anything through the generations, it's discretion. Asked for the craziest thing she ever witnessed, the senior responded, "I don't think I can answer that."