Twenty-five years ago this summer, Tony Kushner’s Angels in America premiered in the tiny Eureka Theatre in San Francisco’s Mission District. Within two years it had won the Pulitzer Prize and begun a New York run that would dominate the Tony Awards two years in a row, revitalize the nonmusical play on Broadway, and change the way gay lives were represented in pop culture. Both parts of Angels, Millennium Approaches and Perestroika, put gay men at the center of American politics, history, and mythology at a time when they were marginalized by the culture at large and dying in waves. It launched the careers of remarkable actors and directors, not to mention the fiercely ambitious firebrand from Louisiana who wrote it—and rewrote it, and rewrote it, and rewrote it again. Its 2003 HBO adaptation was itself a masterpiece that won more Emmys than Roots. But the play also financially wiped out the theater that premiered it; it endured casting and production tumult at every stage of development, from Los Angeles to London to Broadway; its ambitious, sprawling two-part structure tested the endurance of players, technicians, and audiences. Slate talked to more than 50 actors, directors, playwrights, and critics to tell the story ofAngels’ turbulent ascension into the pantheon of great American storytelling—and to discuss the legacy of a play that feels, in an era in which gay Americans have the right to marry but still in many ways live under siege, as crucial as ever.