Dennis Quaid and real estate agent Kimberly Buffington-Quaid are calling it quits again.
According to TMZ, Buffington-Quaid filed for divorce Tuesday. The pair has filed divorce docs twice before in 2012 -- once in March and once in November -- but reconciled both times.
"After careful consideration, we have decided to end our 12-year marriage," they told TMZ Tuesday in a statement. "The decision was made amicably and with mutual respect toward one another."
The pair, who married on Quaid's 500-acre Montana ranch in 2004, have eight-year-old twins together.
This will be Quaid's third divorce. He's previously been married to actresses P.J. Soles and Meg Ryan.